scholarly journals Effects of Refeeding with a Protein-Free Diets Supplemented with Various Essential Amino Acids on the Plasma Insulin-Like Growth Factor-I Concentration in Fasting Young Chickens

2002 ◽  
Vol 15 (3) ◽  
pp. 406-409
Author(s):  
K. Kita ◽  
T. Shibata ◽  
K. Nagao ◽  
J. Hwangbo ◽  
J. Okumura
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Essential Amino Acids ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Plasma insulin-like growth factor I as predictor of progression and all cause mortality in chronic heart failure

2009 ◽  
Vol 19 (6) ◽  
pp. 486-490 ◽  
Author(s):  
Mikkel Andreassen ◽  
Caroline Kistorp ◽  
Ilan Raymond ◽  
Per Hildebrandt ◽  
Finn Gustafsson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Factor ◽  
Chronic Heart Failure ◽  
Plasma Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
All Cause Mortality ◽  
Growth Factor I

scholarly journals Altered intestinal transport of amino acids in cirrhotic rats: the effect of insulin-like growth factor-I

2000 ◽  
Vol 279 (2) ◽  
pp. G319-G324 ◽  
Author(s):  
Maria Pascual ◽  
Inma Castilla-Cortazar ◽  
Elena Urdaneta ◽  
Jorge Quiroga ◽  
Maria Garcia ◽  
...  
Keyword(s):  
Amino Acids ◽  
Growth Factor ◽  
Glutamic Acid ◽  
Intestinal Transport ◽  
Membrane Vesicles ◽  
Insulin Like Growth Factor ◽  
Anabolic Hormone ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

The intestine is an important target organ for insulin-like growth factor-I (IGF-I), an anabolic hormone synthesized in the liver upon growth hormone (GH) stimulation. Levels of IGF-I are reduced in cirrhosis, and altered GH/IGF-I axis may contribute to malnutrition in cirrhotic patients. Our aim was to study Na+-dependent jejunal transport of amino acids (l-leucine, l-proline,l-glutamic acid, and l-cysteine) in cirrhotic rats and to analyze the effect of IGF-I on this function. IGF-I or saline was administered for 2 wk to rats with CCl4-induced cirrhosis and saline was administered to healthy control rats. Transport of amino acids was assessed in brush-border membrane vesicles (BBMV) using 14C- or 35S-labeled amino acids, and the kinetic constants V max and K t were determined. Na+-independent uptake of l-leucine, l-proline,l-glutamic acid, and l-cysteine by BBMV was similar in all groups. Na+-dependent uptake of all four amino acids was significantly diminished in cirrhotic rats compared with both controls and IGF-I-treated cirrhotic rats. The latter two groups exhibited similar V max and K t, whereas untreated cirrhotic rats had reduced V max and increased K tcompared with normal controls and IGF-I-treated cirrhotic animals. In conclusion, the transport of all four tested amino acids by BBMV is impaired in cirrhotic rats, and low doses of IGF-I can correct this defect.

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