scholarly journals Vitamin D Dietary Supplementation: Relationship with Chronic Heart Failure

2018 ◽  
Vol 101 (4) ◽  
pp. 939-941 ◽  
Author(s):  
Giuseppe Dattilo ◽  
Matteo Casale ◽  
Emanuela Avventuroso ◽  
Pasqualina Laganà
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Chronic Heart Failure ◽  
Heart Diseases ◽  
Low Cost ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
World Health ◽  
Regulatory Function

Abstract It is estimated that over 1 billion people worldwide have a deficiency of vitamin D, also known as hypovitaminosis D, which the World Health Organization has defined as a public health problem. Beyond its historical homeostasis regulatory function of calcium and phosphorus, in relation to the preservation of the skeletal system, several studies show today a close connection between hypovitaminosis D and the genesis of rheumatic, autoimmune, neoplastic, and cardiovascular diseases. With exclusive reference to cardiovascular aspects, multiple heart diseases such as hypertension, myocardial ischemia, and heart failures might have deficiency in vitamin D as an important causative factor. Because of the influence of concomitant pathologies caused by antibiotic-resistant agents, the function of this vitamin should be critically evaluated. However, the role of vitamin D remains to be established; only a few studies have tested the effects of its supplementation in patients with chronic heart failure diseases, and reported results are unclear. It is important to implement studies in this field in order to assess the real benefits induced by vitamin D supplementation in cardiovascular patients and, in particular, in patients with heart failure. Should the research confirm actual clinical improvement after treatment with vitamin D, such a supplementation might represent a new low-cost therapeutic approach to improving quality of life.

scholarly journals Vitamin D Deficiency Contributes to the Reduction and Impaired Function of NaïveCD45RA+Regulatory T Cell in Chronic Heart Failure

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Yan-hui Ma ◽  
Yun-lan Zhou ◽  
Chao-yan Yue ◽  
Guang-hui Zhang ◽  
Lin Deng ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
T Cell ◽  
Chronic Heart Failure ◽  
Cardiovascular Health ◽  
Cell Function ◽  
Foxp3 Expression ◽  
Vitamin D Supplementation ◽  
The Impact

The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood. In this study, we demonstrated that plasma 25(OH)D level, negatively associated with NT-ProBNP, correlated with the decreased Treg in CHF compared to the patients with other cardiovascular diseases and healthy and older donors. Naïve Treg cell (CD4+CD45RA+Foxp3loT) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4+T cell afterαCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4+CD45RA+T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretionin vitro. Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.

scholarly journals Vitamin D status in exclusively breast-fed infants and their mothers

2018 ◽  
Vol 5 (5) ◽  
pp. 1966
Author(s):  
Vignesh Kumaran C. R. ◽  
Sundari S. ◽  
Shanthi Ramesh
Keyword(s):  
Vitamin D ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Tropical Country ◽  
Cross Sectional ◽  
Breastfed Infants ◽  
Young Infants ◽  
Vitamin D Levels

Background: India, despite being a tropical country has widespread vitamin D deficiency across all age groups. Present study was conducted to estimate the prevalence of subclinical hypovitaminosis D in exclusively breastfed infants and their mothers and also to study the correlation between the Vitamin D levels of these infants and their mothers.Methods: This cross-sectional study was conducted in 37 exclusively breastfed infants aged 6 months and below and their mothers.  Under strict aseptic precautions 2 ml of blood was taken from each infant and mother and serum levels of 25(OH) D levels were measured by the direct ELISA method. Statistical analysis was done by using chi-square test, one-way ANOVA f-test and student independent t-test.Results: In present study, authors found that 78.3% of the mothers were Vitamin D deficient and 21.7% of the mothers were Vitamin D insufficient. Among the infants, authors found that 91.9% of the infants were Vitamin D deficient and 8.1% of the infants were Vitamin D insufficient. The association between dietary pattern and socio-economic class and mean maternal vitamin D levels was found to be statistically significant (p <0.05).Conclusions: There is a high prevalence of hypovitaminosis D amongst exclusively breastfed infants and their mothers. Hence, public awareness needs to be created regarding the benefits of sunlight exposure. Vitamin D fortification of food products and routine Vitamin D supplementation program for antenatal and lactating mothers and their young infants may be able to address this emerging public health problem in our country.

scholarly journals Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells

2008 ◽  
Vol 200 (2) ◽  
pp. 207-221 ◽  
Author(s):  
Jorge N Artaza ◽  
Keith C Norris
Keyword(s):  
Vitamin D ◽  
Time Course ◽  
Nuclear Translocation ◽  
Active Form ◽  
Public Health Problem ◽  
Plasminogen Activator Inhibitor ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Important Public Health Problem ◽  
Multipotent Cells

Hypovitaminosis D is an important public health problem. Serum 25-hydroxyvitamin D (25-OHD) is now recognized as an independent predictor for cardiovascular and related diseases (CVD) as well as other chronic medical conditions. However, the biologic pathways through which these effects are mediated remain poorly understood. We hypothesized that exposing mesenchymal multipotent cells (MMCs) to the active form of vitamin D would increase the expression of selected antifibrotic factors that in turn would ameliorate the progression of chronic diseases. MMCs were primed with 5′-azacytidine to induce a fibrotic phenotype and then treated with active vitamin D (1,25D) or ethanol <0.1% as vehicle in a time course manner (30 min, 1, 5, and 24 h, and for 4 and 7 days). The addition of 1,25D to MMCs promotes: a) increased expression and nuclear translocation of the vitamin D receptor; b) decreased expression of TGFB1 and plasminogen activator inhibitor (SERPINE1), two well-known profibrotic factors; c) decreased expression of collagen I, III and other collagens isoforms; and d) increased expression of several antifibrotic factors such as BMP7 a TGFB1 antagonist, MMP8 a collagen breakdown inducer and follistatin, an inhibitor of the profibrotic factor myostatin. In conclusion, the addition of 1,25D to differentiated MMCs displays a decreased profibrotic signaling pathway and gene expression, leading to decrease in collagen deposition. This study highlights key mechanistic pathways through which vitamin D decreases fibrosis, and provides a rationale for studies to test vitamin D supplementation as a preventive and/or early treatment strategy for CVD and related fibrotic disorders.

Profiling older community-dwellers with hypovitaminosis D: A classification tree analysis

2020 ◽  
Vol 90 (3-4) ◽  
pp. 195-199 ◽  
Author(s):  
Gaelle Chevallereau ◽  
Mathilde Legeay ◽  
Guillaume T. Duval ◽  
Spyridon N. Karras ◽  
Bruno Fantino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Classification Tree ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
Gait Disorders ◽  
Hydroxyvitamin D ◽  
Chaid Analysis ◽  
Clinical Profiles ◽  
Community Dwellers

Abstract. Despite the high prevalence of hypovitaminosis D in older adults, universal vitamin D supplementation is not recommended due to potential risk of intoxication. Our aim here was to determine the clinical profiles of older community-dwellers with hypovitaminosis D. The perspective is to build novel strategies to screen for and supplement those with hypovitaminosis D. A classification tree (CHAID analysis) was performed on multiple datasets standardizedly collected from 1991 older French community-dwelling volunteers ≥ 65 years in 2009–2012. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D ≤ 50 nmol/L. CHAID analysis retained 5 clinical profiles of older community-dwellers with different risks of hypovitaminosis D up to 87.3%, based on various combinations of the following characteristics: polymorbidity, obesity, sadness and gait disorders. For instance, the probability of hypovitaminosis D was 1.42-fold higher [95CI: 1.27–1.59] for those with polymorbidity and gait disorders compared to those with no polymorbidity, no obesity and no sadness. In conclusion, these easily-recordable measures may be used in clinical routine to identify older community-dwellers for whom vitamin D supplementation should be initiated.

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