scholarly journals Frailty Prevalence in the COMPASS-ND Study of Neurodegenerative Disorders

2019 ◽  
Vol 22 (4) ◽  
pp. 205-212 ◽  
Author(s):  
Jacqueline R. Burt ◽  
Judith Godin ◽  
Josée Filion ◽  
Manuel Montero-Odasso ◽  
Kenneth Rockwood ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Status ◽  
Health Outcomes ◽  
Neurodegenerative Disorders ◽  
Frailty Index ◽  
Frailty Phenotype ◽  
Frailty Status ◽  
Adverse Health ◽  
Adverse Health Outcomes ◽  
The Difference

BackgroundFrailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures.MethodsData from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status accord-ing to FI and FP criteria were ascertained for each participant. Results81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail. ConclusionThe presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.

scholarly journals Validation of a Claims-Based Frailty Index Against Physical Performance and Adverse Health Outcomes in the Health and Retirement Study

2018 ◽  
Vol 74 (8) ◽  
pp. 1271-1276 ◽  
Author(s):  
Dae Hyun Kim ◽  
Robert J Glynn ◽  
Jerry Avorn ◽  
Lewis A Lipsitz ◽  
Kenneth Rockwood ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Grip Strength ◽  
Physical Performance ◽  
Gait Speed ◽  
Daily Living ◽  
Frailty Index ◽  
Activity Of Daily Living ◽  
Adverse Health ◽  
Adverse Health Outcomes ◽  
Retirement Study

Abstract Background A claims-based frailty index (CFI) was developed based on a deficit-accumulation approach using self-reported health information. This study aimed to independently validate the CFI against physical performance and adverse health outcomes. Methods This retrospective cohort study included 3,642 community-dwelling older adults who had at least 1 health care encounter in the year prior to assessments of physical performance in the 2008 Health and Retirement Study wave. A CFI was estimated from Medicare claims data in the past year. Gait speed, grip strength, and the 2-year risk of death, institutionalization, disability, hospitalization, and prolonged (>30 days) skilled nursing facility (SNF) stay were evaluated for CFI categories (robust: <0.15, prefrail: 0.15–0.24, mildly frail: 0.25–0.34, moderate-to-severely frail: ≥0.35). Results The prevalence of robust, prefrail, mildly frail, and moderate-to-severely frail state was 52.7%, 38.0%, 7.1%, and 2.2%, respectively. Individuals with higher CFI had lower mean gait speed (moderate-to-severely frail vs robust: 0.39 vs 0.78 m/s) and weaker grip strength (19.8 vs 28.5 kg). Higher CFI was associated with death (moderate-to-severely frail vs robust: 46% vs 7%), institutionalization (21% vs 5%), activity of daily living disability (33% vs 9%), instrumental activity of daily living disability (100% vs 22%), hospitalization (79% vs 23%), and prolonged SNF stay (17% vs 2%). The odds ratios per 1-SD (=0.07) difference in CFI were 1.46–2.06 for these outcomes, which remained statistically significant after adjustment for age, sex, and a comorbidity index. Conclusion The CFI is useful to identify individuals with poor physical function and at greater risks of adverse health outcomes in Medicare data.

Subjective measures of binge drinking and alcohol-specific adverse health outcomes: a prospective cohort study

Addiction ◽  
2011 ◽  
Vol 107 (2) ◽  
pp. 323-330 ◽  
Author(s):  
Tapio Paljärvi ◽  
Pia Mäkelä ◽  
Kari Poikolainen ◽  
Sakari Suominen ◽  
Josip Car ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Outcomes ◽  
Binge Drinking ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Subjective Measures ◽  
Adverse Health ◽  
Adverse Health Outcomes

scholarly journals Functional ageing in fibrotic interstitial lung disease: the impact of frailty on adverse health outcomes

2019 ◽  
Vol 55 (1) ◽  
pp. 1900647 ◽  
Author(s):  
Sabina A. Guler ◽  
Joanne M. Kwan ◽  
Janice M. Leung ◽  
Nasreen Khalil ◽  
Pearce G. Wilcox ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Interstitial Lung Disease ◽  
Health Outcomes ◽  
Lung Disease ◽  
Clinical Decision Making ◽  
Frailty Index ◽  
Adverse Health ◽  
Adverse Health Outcomes ◽  
The Impact

BackgroundAccelerated biological and functional ageing is common in fibrotic interstitial lung disease (ILD); however, their impact on adverse health outcomes has not been evaluated in this population.MethodsPatients were prospectively recruited from a specialised ILD clinic. Functional ageing was determined by frailty index and biological age by measurement of absolute telomere length (aTL) from patients' peripheral blood leukocytes. Adverse health outcomes included health-related quality of life (St George's Respiratory Questionnaire), number and length of respiratory and non-respiratory hospitalisations, medication tolerability and time to death or lung transplantation. Multivariable models were used to determine the risks and rates of adverse health outcomes associated with the frailty index and aTL.Results540 patients with fibrotic ILD, including 100 with idiopathic pulmonary fibrosis (IPF), provided 749 frailty index assessments, with 189 patients providing blood samples. The frailty index was strongly associated with quality of life, rate of hospitalisation, time to hospital discharge and mortality, including adjustment for age, sex, disease severity and IPF diagnosis. Mortality prognostication was improved by the addition of the frailty index to commonly used clinical parameters and previously validated composite indices. Conversely, aTL was not associated with most adverse health outcomes. The effect of chronological age on outcomes was mediated primarily by the frailty index, and to a lesser extent by aTL.ConclusionsFunctional ageing is associated with adverse health outcomes in patients with fibrotic ILD, indicating the need for consideration of the individual functional age into clinical decision-making.

scholarly journals Associations between a laboratory frailty index and adverse health outcomes across age and sex

2019 ◽  
Vol 2 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Joanna M. Blodgett ◽  
Olga Theou ◽  
Arnold Mitnitski ◽  
Susan E. Howlett ◽  
Kenneth Rockwood
Keyword(s):  
Health Outcomes ◽  
Frailty Index ◽  
Adverse Health ◽  
Adverse Health Outcomes ◽  
Age And Sex
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