scholarly journals Progestogens and Breast Cancer Risk – In Vitro Investigations with Human Benign and Malignant Epithelial Breast Cells

10.5772/23128 ◽  
2011 ◽  
Author(s):  
Alfred O. ◽  
Harald Seeger ◽  
Hans Neubauer
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Cells

scholarly journals Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Heleen K Bronsveld ◽  
Bas ter Braak ◽  
Øystein Karlstad ◽  
Peter Vestergaard ◽  
Jakob Starup-Linde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Insulin Analogues

Increased breast cancer risk in in vitro fertilisation treated women with a multiple pregnancy: A new hypothesis based on historical in vitro fertilisation treatment data

2015 ◽  
Vol 51 (1) ◽  
pp. 112-120 ◽  
Author(s):  
I.M. Krul ◽  
E. Groeneveld ◽  
M. Spaan ◽  
A.W. van den Belt-Dusebout ◽  
T.M. Mooij ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Multiple Pregnancy ◽  
In Vitro Fertilisation ◽  
Treatment Data ◽  
New Hypothesis ◽  
Fertilisation Treatment

Breast Cancer Risk After Ovarian Stimulation for In Vitro Fertilization—Reply

JAMA ◽  
2016 ◽  
Vol 316 (16) ◽  
pp. 1713
Author(s):  
Alexandra W. van den Belt-Dusebout ◽  
Flora E. van Leeuwen ◽  
Curt W. Burger
Keyword(s):  
Breast Cancer ◽  
In Vitro Fertilization ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ovarian Stimulation ◽  
Vitro Fertilization

Comparison of the Effect of Progesterone, Medroxyprogesterone Acetate and Norethisterone on the Proliferation of Human Breast Cancer Cells

2003 ◽  
Vol 9 (1) ◽  
pp. 36-38
Author(s):  
Harald Seeger ◽  
Diethelm Wallwiener ◽  
Alfred O Mueck
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Medroxyprogesterone Acetate ◽  
Human Breast Cancer ◽  
Chemosensitivity Test ◽  
Human Breast ◽  
Long Term Treatment

Objective To investigate in vitro the influence of the three most used progestogens in continuous combined HRT on cell proliferation of the human breast cancer cell line MCF-7. Study design Progesterone (P), medroxyprogesterone acetate (MPA) and norethisterone (NET) were investigated in the range of 0.01 nM to 10 μM alone and in combination with 10 nM oestradiol. Cell proliferation was measured after seven days using the ATP-chemosensitivity test. Results P alone reduced cell proliferation by 20 and 40% at 10−7 and 10−5 M. MPA and NET displayed a significant inhibition of cell proliferation between 20 and 25% for MPA and 23 and 41% for NET over the whole concentration range tested. The effect was greatest at 10−7 M for MPA and at 10−9 M for NET. In combination with oestradiol, P still significantly reduced cell proliferation, the values being between 12 and 61%. For MPA too an inhibitory effect between 20 and 40% was found, whereas for NET the values were between 23 and 38%. Conclusions Our in vitro results indicate that the influence on breast cancer risk using HRT in postmenopausal women may depend on the type of progestogen used as well as on the regimen applied. However, the inhibitory in vitro net effect of the progestogens at clinically relevant dosages is rather minimal and it remains uncertain as to whether progestogens generally may reduce breast cancer risk in long-term treatment. Further clinical trials are urgently required to determine the appropriate choice - if any - of progestogen to complement HRT.

Breast Cancer Risk After Ovarian Stimulation for In Vitro Fertilization

JAMA ◽  
2016 ◽  
Vol 316 (16) ◽  
pp. 1713
Author(s):  
Federica Tomao ◽  
Anselmo Papa ◽  
Silverio Tomao
Keyword(s):  
Breast Cancer ◽  
In Vitro Fertilization ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ovarian Stimulation ◽  
Vitro Fertilization

Effect of drospirenone on proliferation of human benign and cancerous epithelial breast cells

2011 ◽  
Vol 6 (2) ◽  
Author(s):  
Harald Seeger ◽  
Xiangjan Ruan ◽  
Hans Neubauer ◽  
Alfred O. Mueck
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Epithelial Cells ◽  
Cancer Risk ◽  
Human Breast ◽  
Breast Epithelial Cells ◽  
Significant Difference ◽  
Breast Cells ◽  
Breast Epithelial ◽  
Human Breast Epithelial Cells

AbstractProliferation of human breast epithelial cells is regulated by sex hormones. Epidemiological studies indicate that progestogen addition to estrogen therapy can increase breast cancer risk. However, it remains unclear if all progestogens react in a similar manner. Here, the new progestogen drospirenone (DRSP) was compared to progesterone and other synthetic progestins.Human benign epithelial breast cells (HMECs) were incubated for 7 days with DRSP, progesterone (P), medroxyprogesterone acetate (MPA) and levonorgestrel (LNG) in the presence of a growth factor mixture (GF). HCC1500 and T-47D cells (human estrogen and progesterone receptor-positive primary breast cancer cells) were also incubated with the progestogens, but in the presence of estradiol (E2). The proliferation rate was measured by the MTT assay.DRSP and P elicited a similar significant inhibition of proliferation of HMECs in combination with GFs. LNG and MPA had no effect. DRSP, P, MPA and LNG were able to significantly inhibit the proliferation of HCC1500 and T-47D cells in combination with E2. No significant difference between the progestogens was observed in HCC1500 cells, whereas in T-47D cells both DRSP and P were significantly more effective at 10 μM than LNG and MPA.Because different results were found in the same experimental model, it appears that progestogens do not react similarly on the proliferation of human breast epithelial cells. However, for assessment of breast cancer risk different models should be used, because various mechanism(s) might be involved. It is also important to use benign as well as cancerous cell lines. The choice of progestogen could be of significance in terms of breast cancer risk under hormone therapy.

scholarly journals Obesity-related proteins score as a potential marker of breast cancer risk

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sha Diao ◽  
Xueyao Wu ◽  
Xiaofan Zhang ◽  
Yu Hao ◽  
Bin Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Luminal Breast Cancer ◽  
Obese Women ◽  
Related Protein ◽  
Step Method ◽  
Potential Marker ◽  
Related Proteins

AbstractThere is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case–control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS5pre or PS4post) was positively correlated with breast cancer risk (premenopausal: OR≤63 VS >63 3.696, 95% CI 2.025–6.747; postmenopausal: OR≤38 VS >38 7.100, 95% CI 3.134–16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.

scholarly journals Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

2015 ◽  
Vol 22 (1) ◽  
pp. 9-44 ◽  
Author(s):  
Katarína Kráľová ◽  
Josef Jampílek
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Environmental Contaminants ◽  
Atmospheric Pollutants ◽  
Breast Cancer Cell Lines ◽  
Case Control Studies ◽  
Professional Exposure

Abstract Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well

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