scholarly journals Non- Isolation Treatment of Atrial Fibrillation: Does Autonomic Nerve Modulation Really Act?

10.5772/25427 ◽  
2012 ◽  
Author(s):  
Hong-Tao Wang ◽  
Qiang-Sun Zheng ◽  
Xiong-Tao Liu ◽  
Jun Li ◽  
Fu-Jun Shang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Autonomic Nerve

scholarly journals Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression

2018 ◽  
Vol 315 (6) ◽  
pp. H1521-H1531 ◽  
Author(s):  
Xin Liu ◽  
Chuan Qu ◽  
Hongjie Yang ◽  
Shaobo Shi ◽  
Cui Zhang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sympathetic Activity ◽  
Autonomic Nerve ◽  
Electrical Remodeling ◽  
Intragastric Administration ◽  
Chronic Stimulation ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Nerve Dysfunction ◽  
Stimulation Of

The present study aimed to assess the effect of sigma-1 receptor (S1R) stimulation on autonomic nerve dysfunction and susceptibility to atrial fibrillation (AF) in a rat depression model. Male rats were randomly divided into one of the following four treatment groups: saline [control (CTL)]; saline + intragastric administration of SA4503, an agonist of S1R (CTS); chronic unpredictable mild stress (CUMS) to produce depression (MDD); and CUMS + intragastric administration of SA4503 (MDS). Depression-like behaviors, such as reduced sucrose preference, decreased body weight gain, and increased immobility time during forced swimming, improved in the MDS group after 4 wk of SA4503 treatment. Compared with rats in the CTL group, rats in the MDD group showed significantly augmented sympathetic activity, reduced parasympathetic activity, decreased heart rate variability, and lowered S1R expression in the atrium and hippocampus (all P < 0.01). However, rats in the MDS group showed mitigated aforementioned alterations and improved electrical remodeling compared with rats in the MDD group (all P < 0.01). Furthermore, rats in the MDS group showed shortened activation latencies, increased effective refractory periods, and lowered frequency of AF incidence duration and fibrosis compared with rats in the MDD group (all P < 0.01). The results indicate that S1R stimulation reduces sympathetic activity and susceptibility to AF by improving depressive behaviors, modulating cardiac autonomic nerve balance, lightening nerve remodeling, and upregulating S1R and ion channel protein expression. NEW & NOTEWORTHY Chronic stimulation of the sigma-1 receptor (S1R) ameliorates depression-induced autonomic nerve dysfunction by modulating the imbalance between overactivated sympathetic activity and decreased vagal activity. Chronic S1R stimulation alleviates atrial electrical remodeling, fibrosis, and susceptibility to atrial fibrillation (AF). The S1R agonist may target the underlying mechanisms related to AF occurrence. The results indicate that the S1R could be a potential clinical target for atrial arrhythmia, especially when it is combined with major depressive disorders.

Amplitude reduction of autonomic nerve function is correlated with ablation lesion quality in patients with paroxysmal atrial fibrillation

2020 ◽  
Vol 59 ◽  
pp. 158-163
Author(s):  
Sai-Zhe Liu ◽  
Xiang-Min Shi ◽  
Hong-Yang Guo ◽  
Yu-Tang Wang ◽  
Zhao-Liang Shan
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Ablation Lesion ◽  
Autonomic Nerve Function

Autonomic nerve innervation and the left atrium: A mechanistic link to focal atrial fibrillation

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. 523-524 ◽  
Author(s):  
Kathryn A. Glatter ◽  
Nipavan Chiamvimonvat
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrium ◽  
Autonomic Nerve

Canine model of paroxysmal atrial fibrillation and paroxysmal atrial tachycardia

2005 ◽  
Vol 289 (5) ◽  
pp. H1851-H1857 ◽  
Author(s):  
Moshe Swissa ◽  
Shengmei Zhou ◽  
Offir Paz ◽  
Michael C. Fishbein ◽  
Lan S. Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Atrial Tachycardia ◽  
Stellate Ganglion ◽  
Canine Model ◽  
Autonomic Nerve ◽  
High Yield ◽  
Yield Model ◽  
Nerve Sprouting ◽  
Experimental Group

Both autonomic nerve activity and electrical remodeling are important in atrial arrhythmogenesis. Therefore, dogs with sympathetic hyperinnervation, myocardial infarction (MI), and complete atrioventricular block (CAVB) may have a high incidence of atrial arrhythmias. We studied eight dogs (experimental group) with MI, CAVB, and sympathetic hyperinnervation induced either by nerve growth factor infusion ( n = 4 dogs) or subthreshold electrical stimulation ( n = 4 dogs) of the left stellate ganglion. Cardiac rhythm was continuously monitored by a Data Sciences International transmitter for 48 (SD 27) days. Three normal control dogs were also monitored. Six additional normal dogs were used for histology control. Paroxysmal atrial fibrillation (PAF) and paroxysmal atrial tachycardia (PAT) were documented in all dogs in the experimental group, with an average of 3.8 (SD 3) episodes/day, including 1.3 (SD 1.6) episodes of PAF and 2.5 (SD 2.2) episodes of PAT. The duration averaged 298 (SD 745) s (range, 7–4,000 s). There was a circadian pattern of arrhythmia onset ( P < 0.01). Of 576 episodes of PAF and PAT, 236 (41%) episodes occurred during either sustained or nonsustained ventricular tachycardia (VT). Among these 236 episodes, 53% started before VT, whereas 47% started after the onset of VT. Normal dogs did not have either PAF or PAT. The hearts from the experimental group had a higher density of nerve structures immunopositive ( P < 0.01) for three different nerve specific markers in both right and left atria than those of the control dogs. We conclude that the induction of nerve sprouting and sympathetic hyperinnervation in dogs with CAVB and MI creates a high yield model of PAF and PAT.

scholarly journals Autonomic Nerve Modulation Demonstrated by Tilt Table Test in Paroxysmal Atrial Fibrillation

2011 ◽  
Vol 27 (Supplement) ◽  
pp. PE3_035
Author(s):  
I. H. Liu ◽  
Kun T. Lee ◽  
Wen T. Lai
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Autonomic Nerve ◽  
Tilt Table Test ◽  
Tilt Table

scholarly journals e0714 Autonomic nerve remodelling of prolonged rapid atrial pacing-induced atrial fibrillation and reversal effect of propranolol

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A221-A221
Author(s):  
Y. Yu ◽  
L. Liu ◽  
J. Y. Jiang
Keyword(s):  
Atrial Fibrillation ◽  
Autonomic Nerve ◽  
Atrial Pacing ◽  
Reversal Effect

scholarly journals MicroRNA Profiling of Atrial Fibrillation in Canines: MiR-206 Modulates Intrinsic Cardiac Autonomic Nerve Remodeling by Regulating SOD1

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122674 ◽  
Author(s):  
Yujiao Zhang ◽  
Shaohua Zheng ◽  
Yangyang Geng ◽  
Jiao Xue ◽  
Zhongsu Wang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Autonomic Nerve ◽  
Microrna Profiling

scholarly journals Effects of carvedilol on cardiac autonomic nerve activities during sinus rhythm and atrial fibrillation in ambulatory dogs

EP Europace ◽  
2014 ◽  
Vol 16 (7) ◽  
pp. 1083-1091 ◽  
Author(s):  
E.-K. Choi ◽  
M. J. Shen ◽  
S.-F. Lin ◽  
P.-S. Chen ◽  
S. Oh
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Autonomic Nerve

scholarly journals Pulmonary Vein and Superior Vena Cava Isolation for Atrial Fibrillation and Their Long Term Effects on Autonomic Nerve Function

2011 ◽  
Vol 27 (Supplement) ◽  
pp. OP10_3
Author(s):  
Shinsuke Iwai ◽  
Junichi Nitta ◽  
Akira Satou ◽  
Osamu Inaba ◽  
Tsunehiro Yamato ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Superior Vena Cava ◽  
Superior Vena ◽  
Vena Cava ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Long Term Effects ◽  
Autonomic Nerve Function
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