scholarly journals Minimal Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Leukemia ◽  
10.5772/52080 ◽  
2013 ◽  
Author(s):  
W. Zeijlemaker ◽  
G.J. Schuurhuis
Keyword(s):  
Stem Cells ◽  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Leukemic Stem Cells ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals A clinically relevant population of leukemic CD34+CD38− cells in acute myeloid leukemia

Blood ◽  
2012 ◽  
Vol 119 (15) ◽  
pp. 3571-3577 ◽  
Author(s):  
Jonathan M. Gerber ◽  
B. Douglas Smith ◽  
Brownhilda Ngwang ◽  
Hao Zhang ◽  
Milada S. Vala ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Clinical Relapse ◽  
Aldh Activity ◽  
Immunodeficient Mice ◽  
Minimal Residual ◽  
Acute Myeloid

Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34+CD38− cell population. Despite the considerable research on LSCs over the past 2 decades, the clinical significance of these cells remains uncertain. However, if clinically relevant, it is expected that LSCs would be enriched in minimal residual disease and predictive of relapse. CD34+ subpopulations from AML patients were analyzed by flow cytometry throughout treatment. Sorted cell populations were analyzed by fluorescence in situ hybridization for leukemia-specific cytogenetic abnormalities (when present) and by transplantation into immunodeficient mice to determine self-renewal capacity. Intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38− cells capable of engrafting immunodeficient mice from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease detected during complete remission was enriched for the CD34+CD38−ALDHint leukemic cells, and the presence of these cells after therapy highly correlated with subsequent clinical relapse. ALDH activity appears to distinguish normal from leukemic CD34+CD38− cells and identifies those AML cells associated with relapse.

Optimized clinical application of minimal residual disease in acute myeloid leukemia with RUNX1–RUNX1T1

2021 ◽  
Author(s):  
Hui Wei ◽  
Xueou Liu ◽  
Ying Wang ◽  
Dong Lin ◽  
Chunlin Zhou ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Clinical Application ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals Minimal residual disease monitoring via AML1-ETO breakpoint tracing in childhood acute myeloid leukemia

2021 ◽  
Vol 14 (8) ◽  
pp. 101119
Author(s):  
Xiaoyan Chen ◽  
Suyu Zong ◽  
Meihui Yi ◽  
Chao Liu ◽  
Bingrui Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Disease Monitoring ◽  
Minimal Residual Disease Monitoring ◽  
Childhood Acute Myeloid Leukemia ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals The impact of the combination of KIT mutation and minimal residual disease on outcome in t(8;21) acute myeloid leukemia

2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Ya-Zhen Qin ◽  
Qian Jiang ◽  
Yu Wang ◽  
Hao Jiang ◽  
Lan-Ping Xu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Kit Mutation ◽  
The Impact ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis

Haematologica ◽  
2017 ◽  
Vol 102 (5) ◽  
pp. 865-873 ◽  
Author(s):  
Sarah A. Buckley ◽  
Brent L. Wood ◽  
Megan Othus ◽  
Christopher S. Hourigan ◽  
Celalettin Ustun ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Cell Transplantation ◽  
Myeloid Leukemia ◽  
Hematopoietic Cell Transplantation ◽  
Residual Disease ◽  
Meta Analysis ◽  
Hematopoietic Cell ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals Persistence of minimal residual disease assessed by multiparameter flow cytometry is highly prognostic in younger patients with acute myeloid leukemia

Cancer ◽  
2016 ◽  
Vol 123 (3) ◽  
pp. 426-435 ◽  
Author(s):  
Farhad Ravandi ◽  
Jeffrey Jorgensen ◽  
Gautam Borthakur ◽  
Elias Jabbour ◽  
Tapan Kadia ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Multiparameter Flow Cytometry ◽  
Younger Patients ◽  
Minimal Residual ◽  
Acute Myeloid

scholarly journals Minimal residual disease eradication with epigenetic therapy in core binding factor acute myeloid leukemia

2017 ◽  
Vol 92 (9) ◽  
pp. 845-850 ◽  
Author(s):  
Brittany Knick Ragon ◽  
Naval Daver ◽  
Guillermo Garcia-Manero ◽  
Farhad Ravandi ◽  
Jorge Cortes ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Epigenetic Therapy ◽  
Core Binding Factor ◽  
Disease Eradication ◽  
Binding Factor ◽  
Minimal Residual ◽  
Acute Myeloid

Monitoring of minimal residual disease in acute myeloid leukemia

2009 ◽  
Vol 21 (6) ◽  
pp. 582-588 ◽  
Author(s):  
Francesco Buccisano ◽  
Luca Maurillo ◽  
Alessandra Spagnoli ◽  
Maria Ilaria Del Principe ◽  
Eleonora Ceresoli ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Minimal Residual ◽  
Acute Myeloid

Patient-specific microRNA expression profiles as a marker for minimal residual disease in acute myeloid leukemia

Hematology ◽  
2013 ◽  
Vol 19 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Velizar Shivarov ◽  
Angel Stoimenov ◽  
Branimir Spassov ◽  
Svetlana Angelova ◽  
Monika Niagolov ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Minimal Residual Disease ◽  
Myeloid Leukemia ◽  
Residual Disease ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Patient Specific ◽  
Minimal Residual ◽  
Acute Myeloid
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