scholarly journals Roles of Tumor Suppressor Signaling on Reprogramming and Stemness Transition in Somatic Cells

10.5772/55712 ◽  
2013 ◽  
Author(s):  
Arthur Kwok Leung Cheung ◽  
Yee Peng ◽  
Hong Lok ◽  
Josephine Mun Yee Ko ◽  
Yue Cheng ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Somatic Cells

Abstract LB-273: The tumor suppressor p16INK4a regulates extensive plasticity in rare somatic cells found in adult human tissue.

2013 ◽  
Author(s):  
Somdutta Roy ◽  
Philippe Gascard ◽  
Nancy Dumont ◽  
Jianxin Zhao ◽  
Deng Pan ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Tissue ◽  
Somatic Cells ◽  
Adult Human

scholarly journals TERT promoter alterations could provide a solution for Peto’s paradox in rodents

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Balázs Vedelek ◽  
Asha Kiran Maddali ◽  
Nurgul Davenova ◽  
Viktor Vedelek ◽  
Imre M. Boros
Keyword(s):  
Transcription Factor ◽  
Tumor Suppressor ◽  
Binding Sites ◽  
Promoter Activity ◽  
Replicative Senescence ◽  
Somatic Cells ◽  
Telomerase Activity ◽  
Cell Number ◽  
Telomere Shortening ◽  
Tert Promoter

AbstractCancer is a genetic disease caused by changes in gene expression resulting from somatic mutations and epigenetic changes. Although the probability of mutations is proportional with cell number and replication cycles, large bodied species do not develop cancer more frequently than smaller ones. This notion is known as Peto’s paradox, and assumes stronger tumor suppression in larger animals. One of the possible tumor suppressor mechanisms involved could be replicative senescence caused by telomere shortening in the absence of telomerase activity. We analysed telomerase promoter activity and transcription factor binding in mammals to identify the key element of telomerase gene inactivation. We found that the GABPA transcription factor plays a key role in TERT regulation in somatic cells of small rodents, but its binding site is absent in larger beavers. Protein binding and reporter gene assays verify different use of this site in different species. The presence or absence of the GABPA TF site in TERT promoters of rodents correlates with TERT promoter activity; thus it could determine whether replicative senescence plays a tumor suppressor role in these species, which could be in direct relation with body mass. The GABPA TF binding sites that contribute to TERT activity in somatic cells of rodents are analogous to those mutated in human tumors, which activate telomerase by a non-ALT mechanism.

scholarly journals Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells

2004 ◽  
Vol 101 (13) ◽  
pp. 4459-4464 ◽  
Author(s):  
L. Michel ◽  
E. Diaz-Rodriguez ◽  
G. Narayan ◽  
E. Hernando ◽  
V. V. V. S. Murty ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Somatic Cells ◽  
Complete Loss ◽  
Cyclin B

3-D examination of the cytoskeletal sheets of mammalian eggs

1992 ◽  
Vol 50 (1) ◽  
pp. 914-915
Author(s):  
Carolyn A. Larabell ◽  
David G. Capco ◽  
G. Ian Gallicano ◽  
Robert W. McGaughey ◽  
Karsten Dierksen ◽  
...  
Keyword(s):  
Actin Filaments ◽  
Somatic Cells ◽  
Freeze Fracture ◽  
Blastocyst Stage ◽  
Cell Cytoplasm ◽  
Planar Structures ◽  
Cytoskeletal Network ◽  
Entire Cell ◽  
Cytoskeletal Networks ◽  
Mammalian Eggs

Mammalian eggs and embryos contain an elaborate cytoskeletal network of “sheets” which are distributed throughout the entire cell cytoplasm. Cytoskeletal sheets are long, planar structures unlike the cytoskeletal networks typical of somatic cells (actin filaments, microtubules, and intermediate filaments), which are filamentous. These sheets are not found in mammalian somatic cells nor are they found in nonmammalian eggs or embryos. Evidence that they are, indeed, cytoskeletal in nature is derived from studies demonstrating that 1) the sheets are retained in the detergent-resistant cytoskeleton fraction; 2) there are no associated membranes (determined by freeze-fracture); and 3) the sheets dissociate into filaments at the blastocyst stage of embryogenesis. Embedment-free sections of hamster eggs viewed at 60 kV show sheets running across the egg cytoplasm (Fig. 1). Although this approach provides excellent global views of the sheets and their reorganization during development, the mechanism of image formation for embedment-free sections does not permit evaluation of the sheets at high resolution.

CENP-C: An oncogene or tumor suppressor gene? A possible new tumor marker

2001 ◽  
Vol 120 (5) ◽  
pp. A299-A299
Author(s):  
D KAZANOV ◽  
B STERN ◽  
W PYERIN ◽  
O BOECHER ◽  
H STRUL ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Marker ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

773: Loss of Expression of Candidate Tumor Suppressor Gene ATIP/MTUS1 in Human Transitional Cell Carcinoma of the Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 259-259
Author(s):  
Delphine Amsellem-Ouazana ◽  
Clara Nahmias ◽  
Vincent Molinie ◽  
Caroline Elie ◽  
Rosette Lidereau ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Transitional Cell ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Carcinoma Of The Bladder ◽  
Human Transitional Cell Carcinoma

625: Bert-Hogg-Dubé (BHD) Tumor Suppressor Expression in Sporadic Renal Cell Carcinomas

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-171 ◽  
Author(s):  
Dakun Wang ◽  
Jorge L. Yao ◽  
Edward M. Messing ◽  
Susan R. Schoen ◽  
Xiangrong He ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Cell ◽  
Renal Cell Carcinomas
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