Prospects of ‘Omics Based Molecular Approaches in Colorectal Cancer Diagnosis and Treatment in the Developing World: A Case Study in Cape Town, South Africa

Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in the intestinal tract, gut microbiota harvest energy and produce a variety of metabolites to affect the host physiology. However, some of these metabolites are oncogenic factors for CRC. With the advent of metabolomics technology, studies profiling microbiota-derived metabolites have greatly accelerated the progress in our understanding of the host-microbiota metabolism interactions in CRC. In this review, we briefly summarize the present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis, furthermore, we discuss the potential clinical applications of microbial metabolites in cancer diagnosis and treatment.

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ASO Author Reflections: Intersectionality of Social Determinants of Health in Lung and Colorectal Cancer Diagnosis and Treatment

Annals of Surgical Oncology ◽

10.1245/s10434-021-11224-2 ◽

2022 ◽

Author(s):

Mary M. Leech ◽

Julie E. Weiss ◽

Chad Markey ◽

Andrew P. Loehrer

Keyword(s):

Colorectal Cancer ◽

Social Determinants Of Health ◽

Cancer Diagnosis ◽

Social Determinants ◽

Determinants Of Health ◽

Diagnosis And Treatment

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Practice report: Assessing the economic impacts of roads passing through ecologically sensitive areas: a case study in Cape Town, South Africa

Impact Assessment and Project Appraisal ◽

10.3152/146155107x206967 ◽

2007 ◽

Vol 25 (2) ◽

pp. 149-156

Author(s):

Barry Standish ◽

Hugo W. van Zyl

Keyword(s):

South Africa ◽

Economic Impacts ◽

Cape Town ◽

Sensitive Areas

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An Approach to Developing a Prediction Model of Fertility Intent Among HIV-Positive Women and Men in Cape Town, South Africa: A Case Study

AIDS and Behavior ◽

10.1007/s10461-016-1441-7 ◽

2016 ◽

Vol 21 (2) ◽

pp. 597-609 ◽

Cited By ~ 1

Author(s):

Dan Bai ◽

Cheng-Shiun Leu ◽

Joanne E. Mantell ◽

Theresa M. Exner ◽

Diane Cooper ◽

...

Keyword(s):

South Africa ◽

Prediction Model ◽

Cape Town ◽

Hiv Positive ◽

Hiv Positive Women

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The ongoing challenge of restorative justice in South Africa: How and why wealthy suburban congregations are responding to poverty and inequality

HTS Teologiese Studies / Theological Studies ◽

10.4102/hts.v70i2.2022 ◽

2014 ◽

Vol 70 (2) ◽

Cited By ~ 2

Author(s):

Nadine F. Bowers du Toit ◽

Grace Nkomo

Keyword(s):

South Africa ◽

Restorative Justice ◽

Cape Town ◽

Lay Leaders ◽

Poverty And Inequality ◽

The World ◽

Basic Features

South Africa remains one of the most unequal societies in the world and any discussion around poverty and the church’s response cannot exclude this reality. This article attempts to analyse the response of wealthy, ‘majority white’ suburban congregations in the southern suburbs of Cape Town to issues of poverty and inequality. This is attempted through the lense of restorative justice, which is broadly explored and defined through a threefold perspective of reconciliation, reparations and restitution. The first part explores a description of the basic features of poverty and inequality in South Africa today, followed by a discussion on restorative justice. This is followed by the case study, which gives the views of clergy and lay leaders with regard to their congregations’ perspectives and responses to poverty and inequality within the context of restorative justice. Findings from the case study begin to plot a tentative ‘way forward’ as to how our reality can more constructively be engaged from the perspective of congregational involvement in reconstruction of our society.

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