scholarly journals Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 159
Author(s):  
Yao Peng ◽  
Yuqiang Nie ◽  
Jun Yu ◽  
Chi Chun Wong
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Cancer Diagnosis ◽  
Intestinal Tract ◽  
Clinical Applications ◽  
Diagnosis And Treatment ◽  
Clinical Implications ◽  
Microbial Metabolites ◽  
Colorectal Tumorigenesis ◽  
Technology Studies

Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in the intestinal tract, gut microbiota harvest energy and produce a variety of metabolites to affect the host physiology. However, some of these metabolites are oncogenic factors for CRC. With the advent of metabolomics technology, studies profiling microbiota-derived metabolites have greatly accelerated the progress in our understanding of the host-microbiota metabolism interactions in CRC. In this review, we briefly summarize the present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis, furthermore, we discuss the potential clinical applications of microbial metabolites in cancer diagnosis and treatment.

scholarly journals Interplay between the Gut Microbiota and Inflammatory Mediators in the Development of Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 734
Author(s):  
Gwangbeom Heo ◽  
Yunna Lee ◽  
Eunok Im
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Inflammatory Mediators ◽  
Tumor Metastasis ◽  
Intestinal Tract ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Therapeutic Interventions ◽  
Potential Therapeutic Target ◽  
Necrosis Factor

Inflammatory mediators modulate inflammatory pathways during the development of colorectal cancer. Inflammatory mediators secreted by both immune and tumor cells can influence carcinogenesis, progression, and tumor metastasis. The gut microbiota, which colonize the entire intestinal tract, especially the colon, are closely linked to colorectal cancer through an association with inflammatory mediators such as tumor necrosis factor, nuclear factor kappa B, interleukins, and interferons. This association may be a potential therapeutic target, since therapeutic interventions targeting the gut microbiota have been actively investigated in both the laboratory and in clinics and include fecal microbiota transplantation and probiotics.

Impact of cancer diagnosis and treatment on glycaemic control among individuals with colorectal cancer using glucose-lowering drugs

2016 ◽  
Vol 53 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Marjolein M. J. Zanders ◽  
Myrthe P. P. van Herk-Sukel ◽  
Ron M. C. Herings ◽  
Lonneke V. van de Poll-Franse ◽  
Harm R. Haak
Keyword(s):  
Colorectal Cancer ◽  
Glycaemic Control ◽  
Cancer Diagnosis ◽  
Diagnosis And Treatment ◽  
Glucose Lowering

508 THE IMPACT OF RESIDENTIAL SEGREGATION ON COLORECTAL CANCER DIAGNOSIS AND TREATMENT

2020 ◽  
Vol 158 (6) ◽  
pp. S-1514
Author(s):  
Michael Poulson ◽  
Andrea M. Madiedo ◽  
Tracey Dechert ◽  
Jason Hall
Keyword(s):  
Colorectal Cancer ◽  
Residential Segregation ◽  
Cancer Diagnosis ◽  
Diagnosis And Treatment ◽  
The Impact

scholarly journals Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

2021 ◽  
Vol 11 ◽  
Author(s):  
Jianfeng Zhou ◽  
Shangwei Sun ◽  
Siyuan Luan ◽  
Xin Xiao ◽  
Yushang Yang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Gut Microbiota ◽  
Digestive Tract ◽  
Clinical Applications ◽  
Immune Defense ◽  
Clinical Implications ◽  
Esophageal Neoplasia ◽  
Physiological Processes ◽  
Number Of Microorganisms ◽  
Compositional Changes

Esophageal cancer (EC) is a common malignant tumor of the upper digestive tract. The microbiota in the digestive tract epithelium comprises a large number of microorganisms that adapt to the immune defense and interact with the host to form symbiotic networks, which affect many physiological processes such as metabolism, tissue development, and immune response. Reports indicate that there are microbial compositional changes in patients with EC, which provides an important opportunity to advance clinical applications based on findings on the gut microbiota. For example, microbiota detection can be used as a biomarker for screening and prognosis, and microorganism levels can be adjusted to treat cancer and decrease the adverse effects of treatment. This review aims to provide an outline of the gut microbiota in esophageal neoplasia, including the mechanisms involved in microbiota-related carcinogenesis and the prospect of utilizing the microbiota as EC biomarkers and treatment targets. These findings have important implications for translating the use of gut microbiota in clinical applications.

scholarly journals Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 808
Author(s):  
Aïcha Zouggar ◽  
Joshua R. Haebe ◽  
Yannick D. Benoit
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Bowel Disease ◽  
Colorectal Tumorigenesis ◽  
Epigenetic Programming ◽  
Inflammatory Bowel ◽  
The Impact

In a recent publication, Ansari et al. identified gut microbiota as a critical mediator of the intestinal inflammatory response through epigenetic programming of host intestinal epithelium. Exposure to the microbiota induces Ten-Eleven-Translocation (TET)-dependent hypomethylation of genomic elements regulating genes associated with inflammatory response and colorectal cancer. Here, we discuss the impact of such a discovery on the understanding of how the intestinal microbiota may contribute to epigenetic reprogramming and influence the onset of colorectal tumorigenesis. Finally, we examine the prospect of TET inhibition strategies as a therapeutic and/or preventive approach for colorectal cancer in patients afflicted by inflammatory bowel disease.

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