scholarly journals Cadherin-Fc Chimeric Protein-Based Biomaterials: Advancing Stem Cell Technology and Regenerative Medicine Towards Application

10.5772/58287 ◽  
2014 ◽  
Author(s):  
Kakon Nag ◽  
Nihad Adnan ◽  
Koichi Kutsuzawa ◽  
Toshihiro Akaike
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Chimeric Protein ◽  
Stem Cell Technology ◽  
Cell Technology

E-Cadherin – Fc Chimeric Protein-Based Biomaterial: Breaking the Barriers in Stem Cell Technology and Regenerative Medicine

2013 ◽  
Vol 810 ◽  
pp. 41-76 ◽  
Author(s):  
Kakon Nag ◽  
Toshihiro Akaike
Keyword(s):  
Stem Cells ◽  
Cell Culture ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Chimeric Protein ◽  
Biochemical Properties ◽  
Target Cells ◽  
Chimeric Proteins ◽  
Stem Cell Technology ◽  
Cell Technology

Chimeric proteins have been used for years for various purposes ranging from biomaterials to candidate drug molecules, and from bench to bulk. Regenerative medicine needs various kinds of proteins for providing essential factors for maintaining starting cells, like induced pluripotent stem cells (iPSC), and renewal, proliferation, targeted differentiation of these cells, and as extracellular matrix for the experimental cells. However, there are several challenges associated with making functional chimeric proteins for effective application as biomaterial in this field. Fc-chimeric protein technology could be an effective solution to overcome many of them. These tailored proteins are recently becoming superior choice of biomaterials in stem cell technology and regenerative medicine due to their specific advantageous biophysical and biochemical properties over other chimeric forms of same proteins. Recent advances in recombinant protein-related science and technology also expedited the popularity of this kind of engineered protein. Over the last decade our lab has been pioneering this field, and we and others have been successfully applied Fc-chimeric proteins to overcome many critical issues in stem cell technologies targeting regenerative medicine and tissue engineering. Fc-chimeric protein-based biomaterials, specifically, E-cad-Fc have been preferentially applied for coating of cell culture plates for establishing xenogeneic-agent free monolayer stem cell culture and their maintenance, enhanced directed differentiation of stem cells to specific lineages, and non-enzymatic on-site one-step purification of target cells. Here the technology, recent discoveries, and future direction related with the E-cad-Fc-chimeric protein in connection with regenerative medicine are described.

scholarly journals Application of Stem Cell Technology in Dental Regenerative Medicine

2013 ◽  
Vol 2 (6) ◽  
pp. 296-305 ◽  
Author(s):  
Ruoxue Feng ◽  
Chistopher Lengner
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Technology ◽  
Cell Technology

Prospects of Induced Pluripotent Stem Cell Technology in Regenerative Medicine

2011 ◽  
Vol 17 (2) ◽  
pp. 115-124 ◽  
Author(s):  
Feng Zhang ◽  
Fudiman Citra ◽  
Dong-An Wang
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Technology ◽  
Cell Technology ◽  
Induced Pluripotent

scholarly journals Stem Cells: Prospects and Potential Applications in Tanzania: A review

2020 ◽  
Vol 21 (2) ◽  
pp. 1-8
Author(s):  
Afadhali Denis Russa
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Large Scale ◽  
Adult Stem Cells ◽  
Treatment Options ◽  
Stem Cell Technology ◽  
African Countries ◽  
Cell Technology ◽  
Leading Role

Stem cell technology and its application in regenerative medicine is the future gateway for the treatment of most non-communicable diseases (NCDs). As the burden of NCDs continues to rises globally, regenerating the cells, tissues and organs will be the mainstream treatment option. The world is prepared for this intriguing but promising avenue of biomedical technology and medicine but Africa is grossly lagging far behind. African governments, universities, research and health institutions need to take a leading role in empowering and mainstreaming stem cell research.  Moreover, for Africa, there is a huge potential for translating stem cell technology into clinical treatments due to the fact that there are limited treatment options for life-threatening forms of NCDs.  Some African countries have well-developed stem cell facilities and large-scale stem cell therapy centers. The use of adult stem cells in liver failure, diabetes and cardiac infarcts has shown success in some African countries. The present work reviews the status, potential and future prospects of stem cell technology and regenerative medicine in Tanzania with particular emphasis on the adult stem cells applicability into the immediate use inpatient care.  The paper also reviews the available cell identification systems and markers and moral and ethical aspects of stem cell science necessary in the translational treatment regimens. 

scholarly journals A Japanese Bioventure Company's Application of Stem Cell Technology in Regenerative Medicine

2018 ◽  
Vol 40 (11) ◽  
pp. 1801-1806 ◽  
Author(s):  
Masanori Sawada ◽  
Daisuke Sugiyama ◽  
Takenobu Nii ◽  
Katsuhiro Konno ◽  
Hardy T.S. Kagimoto
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Technology ◽  
Cell Technology

scholarly journals Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine

2014 ◽  
Vol 19 (4) ◽  
pp. 330-339 ◽  
Author(s):  
Carol Y. Suh ◽  
Zelun Wang ◽  
Oscar Bártulos ◽  
Yibing Qyang
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Technology ◽  
Cell Technology ◽  
Induced Pluripotent

Stem cell technology: The newest breakthroughs in regenerative medicine

2008 ◽  
Vol 45 (4) ◽  
pp. 461 ◽  
Author(s):  
Muhammad Ashraf ◽  
Stefanie Dimmeler
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Technology ◽  
Cell Technology

Creative regulatory practices to develop stem-cell technology: the way forward for Malaysia

2021 ◽  
Author(s):  
Mohammad Firdaus Bin Abdul Aziz ◽  
Michael Morrison ◽  
Jane Kaye
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Research ◽  
Regulatory System ◽  
Regulatory Mechanisms ◽  
Legal Analysis ◽  
Stem Cell Technology ◽  
Strategic Action ◽  
Cell Technology ◽  
Research Activities

Malaysia aspires to develop regenerative medicine through stem-cell technology. It needs a regulatory system that could facilitate development and prevent unethical practices. A comparative legal analysis on the regulation of stem-cell technology, with a focus on stem-cell research in Malaysia and selected Commonwealth countries that are experienced in regulating this complex technology, demonstrates that the selected Commonwealth countries have adopted a hybrid of different regulatory mechanisms. This paper argues that Malaysia should consider adopting a similar approach to equip relevant authorities with different regulatory mechanisms that are able to promote innovation in stem-cell research activities and cultivate a successful and profitable regenerative medicine industry in the future. Such a strategic action can produce an optimal regulatory outcome and help Malaysia to realize its aspiration.

Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology

2010 ◽  
pp. 127-141 ◽  
Author(s):  
Duanqing Pei ◽  
Jianyong Xu ◽  
Qiang Zhuang ◽  
Hung-Fat Tse ◽  
Miguel A. Esteban
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Technology ◽  
Cell Technology ◽  
Induced Pluripotent
Sign in / Sign up

Export Citation Format

Share Document