scholarly journals Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications

2017 ◽  
Author(s):  
Hechmi Toumi ◽  
Eric Lespessailles ◽  
Marija Mazor
Keyword(s):  
Stem Cell ◽  
Clinical Applications

scholarly journals Advanced techniques and awaited clinical applications for human pluripotent stem cell differentiation into hepatocytes

Hepatology ◽  
2021 ◽  
Author(s):  
Eléanor Luce ◽  
Antonietta Messina ◽  
Jean‐Charles Duclos‐Vallée ◽  
Anne Dubart‐Kupperschmitt
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Pluripotent Stem Cell ◽  
Stem Cell Differentiation ◽  
Clinical Applications ◽  
Human Pluripotent Stem Cell

scholarly journals High Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation

2021 ◽  
Vol 10 (2) ◽  
pp. 293
Author(s):  
Gee-Hye Kim ◽  
Jihye Kwak ◽  
Sung Hee Kim ◽  
Hee Jung Kim ◽  
Hye Kyung Hong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Clinical Applications ◽  
Hematopoietic Stem ◽  
Cd34 Cells ◽  
Hsc Transplantation

Umbilical cord blood (UCB) is used as a source of donor cells for hematopoietic stem cell (HSC) transplantation. The success of transplantation is dependent on the quality of cord blood (CB) units for maximizing the chance of engraftment. Improved outcomes following transplantation are associated with certain factors of cryopreserved CB units: total volume and total nucleated cell (TNC) count, mononuclear cell (MNC) count, and CD34+ cell count. The role of the storage period of CB units in determining the viability and counts of cells is less clear and is related to the quality of cryopreserved CB units. Herein, we demonstrate the recovery of viable TNCs and CD34+ cells, as well as the MNC viability in 20-year-old cryopreserved CB units in a CB bank (MEDIPOST Co., Ltd., Seongnam-si, Gyeonggi-do, Korea). In addition, cell populations in CB units were evaluated for future clinical applications. The stable recovery rate of the viability of cryopreserved CB that had been stored for up to 20 years suggested the possibility of uses of the long-term cryopreservation of CB units. Similar relationships were observed in the recovery of TNCs and CD34+ cells in units of cryopreserved and fresh CB. The high-viability recovery of long-term cryopreserved CB suggests that successful hematopoietic stem cell (HSC) transplantation and other clinical applications, which are suitable for treating incurable diseases, may be performed regardless of long-term storage.

scholarly journals Stem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Rui Li ◽  
Qiu-Xia Lin ◽  
Xue-Zhen Liang ◽  
Guang-Bo Liu ◽  
He Tang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Femoral Head ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Basic Research ◽  
Clinical Applications

scholarly journals Stem cell therapy for lung diseases: From fundamental aspects to clinical applications

2018 ◽  
Vol 64 (10) ◽  
pp. 92 ◽  
Author(s):  
Hossein Hosseinirad ◽  
Mohsen Rashidi ◽  
Mehrdad Moosazadeh Moghaddam ◽  
Hamid Tebyanian ◽  
Soheila Nouraei ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Lung Diseases ◽  
Clinical Applications

scholarly journals Expanded mesenchymal stem cell transplantation is safe in both local injection and vein transfusion

2017 ◽  
Vol 4 (3-4) ◽  
pp. 234-235 ◽  
Author(s):  
Vlassov V Salval ◽  
Yone Moto
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Clinical Applications ◽  
Local Injection ◽  
Mesenchymal Stem Cell Transplantation ◽  
Routine Treatment ◽  
Drug Products ◽  
The World

More than 500 clinical trials are using mesenchymal stem cells (MSCs) in the world to treat some different diseases. The safety of expanded MSC transplantation is the most important thing to ensure that this therapy can become the routine treatment for human diseases. More than five MSCs based stem cell drug products are approved at various countries demonstrated that expanded MSCs are safe in both local injection and transfusion. Moreover, some recent reports for 5 and 10 years followed-up clinical trials using expanded MSCs confirmed that there is not different tumorigenesis between the patients with and without expanded MSC transplantation. This letter aims to provide some evidences about the safety of expanded MSCs in clinical applications. However, the MSC quality should be stritcly controlled during the in vitro MSC expansion.

scholarly journals Stem cell differentiation and expansion for clinical applications of tissue engineering

2007 ◽  
Vol 11 (5) ◽  
pp. 935-944 ◽  
Author(s):  
Pascale V. Guillot ◽  
Wei Cui ◽  
Nicholas M. Fisk ◽  
Dame Julia Polak
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Clinical Applications
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