scholarly journals Nonsteroidal Anti-inflammatory Drugs: Integrated Approach to Physical Medicine and Rehabilitation

2017 ◽  
Author(s):  
Rosa Grazia Bellomo ◽  
Simona Maria Carmignano ◽  
Tommaso Palermo ◽  
Lucia Cosenza ◽  
Andrea Saggini ◽  
...  
Keyword(s):  
Integrated Approach ◽  
Physical Medicine ◽  
Physical Medicine And Rehabilitation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Study of the expression of functionally relative genes in the treatment of coronavirus infection in chickens

2021 ◽  
Vol 51 (5) ◽  
pp. 68-76
Author(s):  
A. S. Bobikova ◽  
V. S. Cherepushkina ◽  
T. E. Mironova ◽  
V. N. Afonyushkin ◽  
N. A. Donchenko ◽  
...  
Keyword(s):  
Integrated Approach ◽  
Antiviral Drugs ◽  
Inflammatory Activity ◽  
Control Group ◽  
Virus Particles ◽  
Infectious Bronchitis ◽  
System A ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Experimental Group

The level of expression of anti-inflammatory cytokines NF-kB, IL-6, IFN-y, Caspasa-3, FC in chickens in the lungs and intestines during the modeling of infectious bronchitis in chickens was studied. To simulate coronavirus pneumonia, the vaccine was administered individually, 10 doses per head orally. The chickens of the 1st experimental group were fed with the Lyumantse preparation at the rate of 3 kg / t of feed, the 2nd experimental group received the Glitsevir drug at the rate of 200 μg / 0.3 ml per head. The chickens of the control group did not receive the preparations. It was revealed that antiviral drugs in the experimental groups suppressed the destruction of epithelial cells in the intestine. This may not always be an indication of a positive character, as in the case of apoptosis, not only the intestinal cells affected by the virus particles but also healthy cells are destroyed. There was a decrease in the number of active macrophages in the intestines of the experimental groups relative to the control. The amount of interferon produced was also below the control, which indicates a decreased activity of the immune system. A higher pro-inflammatory activity in the respiratory system of chickens was detected when Glicevir was used. It consists of increased expression of IL-6, interferon-gamma, macrophage receptor to Fc antibody fragments and inflammatory regulatory factor NF-kB genes compared to Lumantse with anti-inflammatory activity, but also compared to untreated control group chickens. It is concluded that it is possible to predict the risk of an exacerbation of an infectious process in the lungs against the background of a local decrease in the viral load in the intestine. An integrated approach is needed in the treatment of coronavirus infections, including either systemic antiviral drugs or anti-inflammatory drugs.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Future perspectives in physical medicine and rehabilitation

JAMA ◽  
1966 ◽  
Vol 198 (9) ◽  
pp. 1017-1018
Author(s):  
L. D. Policoff
Keyword(s):  
Future Perspectives ◽  
Physical Medicine ◽  
Physical Medicine And Rehabilitation

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

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