scholarly journals Designing for Embodied and Rich Interaction in Home IoT

2017 ◽  
Author(s):  
Joep Frens
Keyword(s):  
Rich Interaction

scholarly journals Regulation of Smooth Muscle Cell Differentiation by AT-Rich Interaction Domain Transcription Factors Mrf2α and Mrf2β

2002 ◽  
Vol 91 (5) ◽  
pp. 382-389 ◽  
Author(s):  
Masafumi Watanabe ◽  
Matthew D. Layne ◽  
Chung-Ming Hsieh ◽  
Koji Maemura ◽  
Susan Gray ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Interaction Domain ◽  
Muscle Cell Differentiation ◽  
Smooth Muscle Cell Differentiation ◽  
Rich Interaction

scholarly journals The interaction landscape between transcription factors and the nucleosome

2017 ◽  
Author(s):  
Fangjie Zhu ◽  
Lucas Farnung ◽  
Eevi Kaasinen ◽  
Biswajyoti Sahu ◽  
Yimeng Yin ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Affinity Purification ◽  
Rotational Symmetry ◽  
Free Dna ◽  
Nucleosomal Dna ◽  
Direct Gene ◽  
Systematic Evolution ◽  
Modes Of Interaction ◽  
Exponential Enrichment ◽  
Rich Interaction

Nucleosomes cover most of the genome and are thought to be displaced by transcription factors (TFs) in regions that direct gene expression. However, the modes of interaction between TFs and nucleosomal DNA remain largely unknown. Here, we use nucleosome consecutive affinity-purification systematic evolution of ligands by exponential enrichment (NCAP-SELEX) to systematically explore interactions between the nucleosome and 220 TFs representing diverse structural families. Consistently with earlier observations, we find that the vast majority of TFs have less access to nucleosomal DNA than to free DNA. The motifs recovered from TFs bound to nucleosomal and free DNA are generally similar; however, steric hindrance and scaffolding by the nucleosome result in specific positioning and orientation of the motifs. Many TFs preferentially bind close to the end of nucleosomal DNA, or to periodic positions at its solvent-exposed side. TFs often also bind nucleosomal DNA in a particular orientation, because the nucleosome breaks the local rotational symmetry of DNA. Some TFs also specifically interact with DNA located at the dyad position where only one DNA gyre is wound, whereas other TFs prefer sites spanning two DNA gyres and bind specifically to each of them. Our work reveals striking differences in TF binding to free and nucleosomal DNA, and uncovers a rich interaction landscape between the TFs and the nucleosome.

AT‐rich interaction domain 5A regulates the transcription of interleukin‐6 gene in prostate cancer cells

The Prostate ◽  
2021 ◽  
Author(s):  
Wataru Ikeuchi ◽  
Yuriko Wakita ◽  
Guoxiang Zhang ◽  
Chun Li ◽  
Keiichi Itakura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Prostate Cancer Cells ◽  
Interaction Domain ◽  
Rich Interaction

An Interactive Space as a Creature

2017 ◽  
Vol 1 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Ulysses Bernardet ◽  
Jaume Subirats Aleixandri ◽  
Paul F.M.J. Verschure
Keyword(s):  
Systematic Approach ◽  
Nonlinear Relationship ◽  
Sweet Spot ◽  
Theoretical Relationship ◽  
Key Factor ◽  
Modes Of Interaction ◽  
Experience Of Flow ◽  
Rich Interaction ◽  
Living Being

Interacting with an animal is a highly immersing and satisfactory experience. How can interaction with an artifact can be imbued with the quality of an interaction with a living being? The authors propose a theoretical relationship that puts the predictability of the human-artifact interaction at the center of the attribution of agency and experience of “flow.” They empirically explored three modes of interaction that differed in the level of predictability of the interactive space's behavior. The results of the authors' study give support to the notion that there is a sweet spot of predictability in the reactions of the space that leads users to perceive the space as a creature. Flow factors discriminated between the different modes of interaction and showed the expected nonlinear relationship with the predictability of the interaction. The authors' results show that predictability is a key factor to induce an attribution of agency, and they hope that their study can contribute to a more systematic approach to designing satisfactory and rich interaction between humans and machines.

Modular and Systematic Interface Design for Rich Internet Applications

2010 ◽  
pp. 59-74 ◽  
Author(s):  
Gustavo Rossi ◽  
Matias Urbieta ◽  
Jeronimo Ginzburg
Keyword(s):  
User Interface ◽  
Interface Design ◽  
Web Applications ◽  
Design Method ◽  
Internet Applications ◽  
Rich Internet Applications ◽  
Interaction Styles ◽  
Hypermedia Design ◽  
High Level ◽  
Rich Interaction

In this chapter, we present a design approach for the interface of rich Internet applications, that is, those Web applications in which the conventional hypermedia paradigm has been improved with rich interaction styles. Our approach combines well-known techniques for advanced separation of concerns such as aspect-oriented software design, with the object oriented hypermedia design method (OOHDM) design model allowing to express in a high level way the structure and behaviours of the user interface as oblivious compositions of simpler interface atoms. Using simple illustrative examples we present the rationale of our approach, its core stages and the way it is integrated into the OOHDM. Some implementation issues are finally analyzed.

scholarly journals MicroRNA-376c-3p Facilitates Human Hepatocellular Carcinoma Progression via Repressing AT-Rich Interaction Domain 2

2018 ◽  
Vol 9 (22) ◽  
pp. 4187-4196 ◽  
Author(s):  
Yuan Wang ◽  
Weiping Chang ◽  
Wanli Chang ◽  
Xiaowei Chang ◽  
Song Zhai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Interaction Domain ◽  
Rich Interaction

scholarly journals Structure and DNA-binding Sites of the SWI1 AT-rich Interaction Domain (ARID) Suggest Determinants for Sequence-specific DNA Recognition

2004 ◽  
Vol 279 (16) ◽  
pp. 16670-16676 ◽  
Author(s):  
Suhkmann Kim ◽  
Ziming Zhang ◽  
Sean Upchurch ◽  
Nancy Isern ◽  
Yuan Chen
Keyword(s):  
Dna Binding ◽  
Binding Sites ◽  
Dna Recognition ◽  
Interaction Domain ◽  
Dna Binding Sites ◽  
Rich Interaction

scholarly journals Molecular determinants of complex formation between DNA and the AT ‐rich interaction domain of BAF 250a

FEBS Letters ◽  
2019 ◽  
Vol 593 (19) ◽  
pp. 2716-2729 ◽  
Author(s):  
Aditi Maulik ◽  
Malyasree Giri ◽  
Mahavir Singh
Keyword(s):  
Complex Formation ◽  
Interaction Domain ◽  
Molecular Determinants ◽  
Rich Interaction
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