scholarly journals Calcium Phosphate/Clay Nanotube Bone Cement with Enhanced Mechanical Properties and Sustained Drug Release

Author(s):  
Udayabhanu Jammalamadaka ◽  
Karthik Tappa ◽  
David K. Mills
RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7708-7717 ◽  
Author(s):  
Rong Zhou ◽  
Hai-Jian Ni ◽  
Jin-Hui Peng ◽  
Ning Liu ◽  
Shu Chen ◽  
...  

Calcium phosphate modified tantalum scaffolds displayed high performance on mineralization, sustained drug release and in vivo bone defect repair.


2007 ◽  
Vol 336-338 ◽  
pp. 1654-1657
Author(s):  
Rui Liu ◽  
Li Min Dong ◽  
Qing Feng Zan ◽  
Chen Wang ◽  
Jie Mo Tian

The aim of this work is to improve the mechanical properties of calcium phosphate bone cement (CPC) by appending chitosan microspheres to CPC base. That chitosan degrades rapidly than bone cement has been proved by previous investigations. Porous CPC has low compressive strength because of the pores in it weakening the structure. Additive chitosan microspheres can improve the mechanical properties by bearing the compress with the CPC base and produce pores after degradation. This study investigates the effect of chitosan microspheres on the setting time, mechanical properties, phase evolution and morphology of CPC. The additive proportion of chitosan microspheres ranges from 0 wt% to 30 wt%. Compared with original CPC, the modified CPC has higher compressive strength, without significantly affecting the chemical properties. The phase composition of the CPC is tested by XRD. The microstructures of CPC are observed using SEM. The final setting times range from 5~15 minutes and can be modulated by using different liquid and powder (L/P) ratio.


Biomaterials ◽  
2012 ◽  
Vol 33 (27) ◽  
pp. 6447-6455 ◽  
Author(s):  
Feng Chen ◽  
Peng Huang ◽  
Ying-Jie Zhu ◽  
Jin Wu ◽  
Da-Xiang Cui

2015 ◽  
Vol 104 (2) ◽  
pp. 308-315 ◽  
Author(s):  
Iwan Palmer ◽  
John Nelson ◽  
Wolfgang Schatton ◽  
Nicholas J. Dunne ◽  
Fraser J. Buchanan ◽  
...  

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