Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement

2007 ◽  
Vol 336-338 ◽  
pp. 1654-1657
Author(s):  
Rui Liu ◽  
Li Min Dong ◽  
Qing Feng Zan ◽  
Chen Wang ◽  
Jie Mo Tian
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Setting Time ◽  
Chemical Properties ◽  
Phase Evolution ◽  
Chitosan Microspheres ◽  
Setting Times ◽  
Calcium Phosphate Bone Cement

The aim of this work is to improve the mechanical properties of calcium phosphate bone cement (CPC) by appending chitosan microspheres to CPC base. That chitosan degrades rapidly than bone cement has been proved by previous investigations. Porous CPC has low compressive strength because of the pores in it weakening the structure. Additive chitosan microspheres can improve the mechanical properties by bearing the compress with the CPC base and produce pores after degradation. This study investigates the effect of chitosan microspheres on the setting time, mechanical properties, phase evolution and morphology of CPC. The additive proportion of chitosan microspheres ranges from 0 wt% to 30 wt%. Compared with original CPC, the modified CPC has higher compressive strength, without significantly affecting the chemical properties. The phase composition of the CPC is tested by XRD. The microstructures of CPC are observed using SEM. The final setting times range from 5~15 minutes and can be modulated by using different liquid and powder (L/P) ratio.

scholarly journals Photoluminescent Eu3+-Doped Calcium Phosphate Bone Cement and Its Mechanical Properties

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1610 ◽  
Author(s):  
Annemarie Oesterle ◽  
Anne Boehm ◽  
Frank Müller
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Setting Time ◽  
Bone Cements ◽  
X Ray ◽  
Novel Approach ◽  
Calcium Phosphate Bone Cement ◽  
Negative Effect ◽  
Healing Processes

Calcium phosphate cements (CPC) are well-established bone replacement materials that have been used in dentistry and orthopedics for more than 25 years. The monitoring of bone cements and the associated healing processes in the human body is difficult and so far has often been achieved using cytotoxic X-ray contrast agent additives. These additives have a negative effect on the mechanical properties and setting time of the bone cement. In this paper, we present a novel approach to prepare contrastive CPC by the incorporation of luminescent Eu3+-doped hydroxyapatite (Eu:HAp) nanoparticles. Eu-doped CPC (Eu:CPC) exhibited enhanced mechanical properties compared to pure CPC. Furthermore, the red photoluminescence of Eu:CPC may allow the observation of CPC-related healing processes without the use of harmful ionizing radiation.

scholarly journals Prediction of the Setting Properties of Calcium Phosphate Bone Cement

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Seyed Mahmud Rabiee ◽  
Hamid Baseri
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Setting Time ◽  
Bone Substitutes ◽  
Setting Times ◽  
Calcium Phosphate Bone Cement ◽  
Poly Ethylene ◽  
Predicted Values ◽  
Inference Systems ◽  
Glycol Solution

Setting properties of bone substitutes are improved using an injectable system. The injectable bone graft substitutes can be molded to the shape of the bone cavity and set in situ when injected. Such system is useful for surgical operation. The powder part of the injectable bone cement is included ofβ-tricalcium phosphate, calcium carbonate, and dicalcium phosphate and the liquid part contains poly ethylene glycol solution with different concentrations. In this way, prediction of the mechanical properties, setting times, and injectability helps to optimize the calcium phosphate bone cement properties. The objective of this study is development of three different adaptive neurofuzzy inference systems (ANFISs) for estimation of compression strength, setting time, and injectability using the data generated based on experimental observations. The input parameters of models are polyethylene glycol percent and liquid/powder ratio. Comparison of the predicted values and measured data indicates that the ANFIS model has an acceptable performance to the estimation of calcium phosphate bone cement properties.

scholarly journals Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

2020 ◽  
Author(s):  
Changtian Gong ◽  
Shuo Fang ◽  
Kezhou Xia ◽  
Jingteng Chen ◽  
Liangyu Guo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Ph Value ◽  
Setting Time ◽  
Potassium Phosphate ◽  
Carboxymethyl Chitosan ◽  
Bioactive Substances ◽  
Magnesium Potassium Phosphate Cement

Abstract Incorporating bioactive substances into synthetic bioceramic scaffolds is challenging. In this work, oxygen-carboxymethyl chitosan (O-CMC), a natural biopolymer that is nontoxic, biodegradable and biocompatible, was introduced into magnesium potassium phosphate cement (K-struvite) to enhance its mechanical properties and cytocompatibility. This study aimed to develop O-CMC/magnesium potassium phosphate composite bone cement (OMPC), thereby combining the optimum bioactivity of O-CMC with the extraordinary self-setting properties and mechanical intensity of the K-struvite. Our results indicated that O-CMC incorporation increased the compressive strength and setting time of K-struvite and decreased its porosity and pH value. Furthermore, OMPC scaffolds remarkably improved the proliferation, adhesion and osteogenesis related differentiation of MC3T3-E1 cells. Therefore, O-CMC introduced suitable physicochemical properties to K-struvite and enhanced its cytocompatibility for use in bone regeneration.

scholarly journals A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System

2021 ◽  
Vol 9 ◽  
Author(s):  
Lijuan Sun ◽  
Tongyang Li ◽  
Sen Yu ◽  
Mengmeng Mao ◽  
Dagang Guo
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Setting Time ◽  
Synthesis Temperature ◽  
Transformation Rate ◽  
Step Method ◽  
Cement Powder ◽  
Calcium Phosphate Bone Cement ◽  
One Step ◽  
Application Potential

In recent years, strontium-substituted calcium phosphate bone cement (Sr-CPC) has attracted more and more attentions in the field of bone tissue repair due to its comprehensive advantages of both traditional CPC and Sr ions. In this study, a crucial Sr-containing α-Ca3–xSrx(PO4)2 salt has been synthesized using a simplified one-step method at lower synthesis temperature. A novel Sr-CPC has been developed based on the simple binary Sr-containing α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder. The physicochemical properties and hydration mechanism of this Sr-CPC at various Sr contents were intensively investigated. The setting product of this Sr-CPC after a set for 72 h is a single-phase Sr-containing hydroxyapatite, and its compressive strength slightly decreased and its setting time extended with the increase of Sr content. The hydration process included the initial formation of the medium product CaHPO4⋅2H2O (30 min∼1 h), the following complete hydration of Ca4(PO4)2O and the initially formed CaHPO4⋅2H2O (2∼6 h), and the final self-setting of α-Ca3–xSrx(PO4)2 (6 h∼). The compressive strength of Sr-CPC, which was closely related to the transformation rate of Sr-containing hydroxyapatite, tended to increase with the extension of hydration time. In addition, Sr-CPC possessed favorable cytocompatibility and the effect of Sr ions on cytocompatibility of Sr-CPC was not obvious at low Sr contents. The present study suggests α-Ca3–xSrx(PO4)2 is a kind of vital Sr-containing salt source which is useful to develop some novel Sr-containing biomaterials. In addition, the new Sr-containing cement system based on this simple binary α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder displayed an attractive clinical application potential in orthopedics.

Stearate Salts as Brushite Bone Cement Setting Retardants

2005 ◽  
Vol 284-286 ◽  
pp. 19-22 ◽  
Author(s):  
M.P. Hofmann ◽  
Uwe Gbureck ◽  
Liam M. Grover ◽  
J.E. Barralet
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Sodium Stearate ◽  
Setting Times ◽  
Powder Component ◽  
Cement System ◽  
Cement Setting

This study sought to examine the efficiency of coating cement powder reactants in order to reduce the solubility rate of reactants and thereby increase setting times of cement systems. In this investigation magnesium and sodium stearate salts were used to coat the highly soluble monocalcium phosphate monohydrate (MCPM) powder component of a hydraulic brushite forming calcium phosphate cement system with b-tricalcium phosphate (b-TCP) as other component. The results showed that stearate coating of the MCPM reactant could lead to a 100% increase in setting and working times without affecting compressive strength of the set cement when applied with the appropriate P/L-ratio.

Rheological Properties of an Injectable Calcium Phosphate Bone Cement and their Relationship with the Phase Evolution

2007 ◽  
Vol 336-338 ◽  
pp. 1658-1661
Author(s):  
Jian Dong Ye ◽  
Xiu Peng Wang ◽  
Ying Jun Wang
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Yield Stress ◽  
Invasive Surgery ◽  
Phase Evolution ◽  
Hydration Reaction ◽  
Dicalcium Phosphate Dihydrate ◽  
Non Invasive ◽  
Phosphate Dihydrate ◽  
Calcium Phosphate Bone Cement

An injectable calcium phosphate bone cement was prepared by combining amorphous calcium phosphate (ACP) and dicalcium phosphate dihydrate (DCPD) for use in non-invasive surgery in this work. The effect of the conserving time on the viscosity, yield stress and injectability of the calcium phosphate cement (CPC) pastes were studied. The results showed that as the conserving time of the pastes prolonged, the viscosity and the yield stress of the pastes increased exponentially, and the injectability of the pastes decreased. This resulted from the transformation of DCPD and ACP into hydroxyapatite via hydration reaction. The results also indicated that the pastes still exhibited good injectability in even 15 min after preparation of the CPC pastes.

scholarly journals Injectable Enzymatically Hardened Calcium Phosphate Biocement

2020 ◽  
Vol 11 (4) ◽  
pp. 74
Author(s):  
Lubomir Medvecky ◽  
Radoslava Štulajterová ◽  
Maria Giretova ◽  
Lenka Luptakova ◽  
Tibor Sopčák
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Setting Time ◽  
Microstructural Analysis ◽  
Chemical Properties ◽  
Gene Expressions ◽  
Cement Pastes ◽  
Anionic Polyelectrolyte ◽  
Simple Possibility

(1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose anionic polyelectrolyte (PAA/CMC) and enhanced bioactivity. (2) Methods: Composite cements were prepared by mixing of calcium phosphate powder mixture with hardening liquid containing anionic polyelectrolyte. Phase and microstructural analysis, compressive strength, release of ions and in vitro testing were used for the evaluation of cement properties. (3) Results: The simple possibility to control the setting time of self-setting CXI cements was shown (7–28 min) by the change in P/L ratio or PHYT/F3P reaction time. The wet compressive strength of cements (up to 15 MPa) was close to cancellous bone. The increase in PAA content to 1 wt% caused refinement and change in the morphology of hydroxyapatite particles. Cement pastes had a high resistance to wash-out in a short time after cement mixing. The noncytotoxic character of CX cement extracts was verified. Moreover, PHYT supported the formation of Ca deposits, and the additional synergistic effect of PAA and CMC on enhanced ALP activity was found, along with the strong up-regulation of osteogenic gene expressions for osteopontin, osteocalcin and IGF1 growth factor evaluated by the RT-qPCR analysis in osteogenic αMEM 50% CXI extracts. (4) Conclusions: The fully injectable composite calcium phosphate bicements with anionic polyelectrolyte addition showed good mechanical and physico-chemical properties and enhanced osteogenic bioactivity which is a promising assumption for their application in bone defect regeneration.

Preparation and Characterization of Silk Fibroin/Calcium Phosphate Composite

2011 ◽  
Vol 332-334 ◽  
pp. 1655-1658
Author(s):  
Biao Wang ◽  
Rui Juan Xie ◽  
Yang Yang Huang
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Silk Fibroin ◽  
Solid Phase ◽  
Setting Time ◽  
Testing Machine ◽  
X Ray Diffraction ◽  
Acicular Crystal ◽  
Setting Times

In this paper, calcium phosphate cement (CPC) was prepared with tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA) system as solid phase and phosphate buffered solution (PBS) as liquid phase, then silk fibroin (SF) was added into CPC to form silk fibroin/calcium phosphate composite. To study the effect of SF on the properties of composite, different mass fraction of SF was added into the composite. The surface morphology was observed by Scanning Electron Microscope. The setting time was investigated by ISO Cement Standard Consistency Instrument. The structure of the composite was studied by X-ray diffraction and infrared spectroscopy. Mechanical properties of samples were tested by Instron Universal Testing Machine. The results showed that the particles of SF could be seen obviously in the surface of all composite, and acicular crystal of hydroxyapatite (HA) was formed in the hardening body of both the composite and the pure CPC. The acicular crystal of HA derived from composite with SF appeared to be thinner. The setting times of the composites were all between 9 to 15min. Compared to pure CPC, the compressive strength and work-of-compressive of composites were all improved. The compressive strength of the composite with 1% SF increased obviously.

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