scholarly journals Regulatory Mechanisms and Chemical Signaling of Mediators Involved in the Inflammatory Phase of Cutaneous Wound Healing

2019 ◽  
Author(s):  
Fernando Pereira Beserra ◽  
Lucas Fernando Sérgio Gushiken ◽  
Maria Fernanda Hussni ◽  
Cláudia Helena Pellizzon
Keyword(s):  
Wound Healing ◽  
Regulatory Mechanisms ◽  
Cutaneous Wound Healing ◽  
Chemical Signaling ◽  
Cutaneous Wound ◽  
Inflammatory Phase

scholarly journals Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome

2008 ◽  
Vol 34 (2) ◽  
pp. 162-184 ◽  
Author(s):  
Sashwati Roy ◽  
Savita Khanna ◽  
Cameron Rink ◽  
Sabyasachi Biswas ◽  
Chandan K. Sen
Keyword(s):  
Wound Healing ◽  
Receptor Interaction ◽  
Cutaneous Wound Healing ◽  
Wound Edge ◽  
Cutaneous Wound ◽  
Rapid Induction ◽  
Inflammatory Phase ◽  
Genes Encoding ◽  
Oxidative Phosphorylation Pathway ◽  
Healing Wound

This work represents a maiden effort to systematically screen the transcriptome of the healing wound-edge tissue temporally using high-density GeneChips. Changes during the acute inflammatory phase of murine excisional wounds were characterized histologically. Sets of genes that significantly changed in expression during healing could be segregated into the following five sets: up-early (6–24 h; cytokine-cytokine receptor interaction pathway), up-intermediary (12–96 h; leukocyte-endothelial interaction pathway), up-late (48–96 h; cell-cycle pathway), down-early (6–12 h; purine metabolism) and down-intermediary (12–96 h; oxidative phosphorylation pathway). Results from microarray and real-time PCR analyses were consistent. Results listing all genes that were significantly changed at any specific time point were further mined for cell-type (neutrophils, macrophages, endothelial, fibroblasts, and pluripotent stem cells) specificity. Candidate genes were also clustered on the basis of their functional annotation, linking them to inflammation, angiogenesis, reactive oxygen species (ROS), or extracellular matrix (ECM) categories. Rapid induction of genes encoding NADPH oxidase subunits and downregulation of catalase in response to wounding is consistent with the fact that low levels of endogenous H2O2is required for wound healing. Angiogenic genes, previously not connected to cutaneous wound healing, that were induced in the healing wound-edge included adiponectin, epiregulin, angiomotin, Nogo, and VEGF-B. This study provides a digested database that may serve as a valuable reference tool to develop novel hypotheses aiming to elucidate the biology of cutaneous wound healing comprehensively.

CD1d-restricted NKT cells regulate the inflammatory phase of cutaneous wound healing

2007 ◽  
Vol 205 (3) ◽  
pp. S54
Author(s):  
David F. Schneider ◽  
Julia M. Tulley ◽  
Jessica L. Palmer ◽  
Richard L. Gamelli ◽  
Douglas E. Faunce
Keyword(s):  
Wound Healing ◽  
Nkt Cells ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Inflammatory Phase

scholarly journals Reviewing the Physiology of Cutaneous Wound Healing and Evaluating the Effect of Exercise on it: A Narrative Review Article

2021 ◽  
Vol 19 (3) ◽  
Author(s):  
Fatima Riyahi ◽  
Simin Riahy ◽  
Mitra Yousefpour
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Herbal Medicines ◽  
The Body ◽  
Cutaneous Wound Healing ◽  
Skin Damage ◽  
Cutaneous Wound ◽  
Inflammatory Phase ◽  
Anti Inflammatory

Context: The skin is the most important organ of the body, and maintaining its integrity is important for health. Severe skin damage is life-threatening, and wound healing restores its integrity. One of the main health problems is impaired cutaneous wound healing. According to the importance of wound healing and the fact that unrepaired skin decreases the quality of life, many studies have investigated the effect of some natural and chemical substances on the length and quality of wound healing to find beneficial interventions for rapid and economical treatment. Objectives: This review was conducted to describe the physiology of cutaneous wound healing and some positive and negative factors affecting it with a focus on exercise. Methods: An electronic search without any time limitation was performed on the PubMed, Google Scholar, and Web of Science databases. The keywords were ‘wound’, ‘healing’, and ‘exercise’. Finally, according to the similarities or differences between the results and the relationship with the subject, 53 papers were selected and reviewed. Results: Wound healing is a complex physiological process with four overlapping processes. It seems that disturbance in the inflammatory phase of wound healing is the main factor in the impairment of healing. Traditionally, many chemical and herbal medicines and compounds have been used to speed up wound recovery due to their anti-inflammatory and antioxidative properties. Many studies have evaluated the effect of exercise, as complementary medicine, on wound healing, and they have examined the effect of different protocols of exercise on the speed of wound healing. According to the results of these studies, aerobic exercise, due to its anti-inflammatory and antioxidative effects, is a beneficial method in shortening the length of healing, especially in aged, obese, and diabetic individuals. Conclusions: Exercise as a low-cost intervention is a good strategy in the treatment of impaired and chronic wounds.

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time

A histological study of the early stages of cutaneous wound healing in lizards inin vivo andin vitro

1972 ◽  
Vol 180 (2) ◽  
pp. 175-185 ◽  
Author(s):  
P. F. A. Maderson ◽  
S. I. Roth
Keyword(s):  
Wound Healing ◽  
Histological Study ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Early Stages

Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing

2021 ◽  
Vol 122 ◽  
pp. 199-210
Author(s):  
Chen Wang ◽  
Guoyun Li ◽  
Kaige Cui ◽  
Zihan Chai ◽  
Ziyu Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Adipose-derived stem cell secretome as a cell-free product for cutaneous wound healing

3 Biotech ◽  
2021 ◽  
Vol 11 (9) ◽  
Author(s):  
Amita Ajit ◽  
Indu Ambika Gopalankutty
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Free Product ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
A Cell ◽  
Adipose Derived Stem Cell
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