scholarly journals Invasiveness-Related Proteomic Variations and Molecular Network Changes in Human Nonfunctional Pituitary Adenomas

2019 ◽  
Author(s):  
Xianquan Zhan ◽  
Xiaohan Zhan ◽  
Xiaowei Wang
Keyword(s):  
Pituitary Adenomas ◽  
Molecular Network ◽  
Nonfunctional Pituitary Adenomas

Fractionated Stereotactic Radiotherapy for Pituitary Adenomas

Neurosurgery ◽  
2015 ◽  
Vol 79 (3) ◽  
pp. 406-417 ◽  
Author(s):  
Sean M. Barber ◽  
Bin S. Teh ◽  
David S. Baskin
Keyword(s):  
Stereotactic Radiotherapy ◽  
Pituitary Adenomas ◽  
Progression Free Survival ◽  
Hormonal Control ◽  
Fractionated Stereotactic Radiotherapy ◽  
Small Series ◽  
Early Results ◽  
Nonfunctional Pituitary Adenomas

Abstract BACKGROUND Early results of postoperative fractionated stereotactic radiotherapy (FSRT) for functional and nonfunctional pituitary adenomas appear promising, but the majority of available evidence draws from small series with insufficient follow-up data to draw meaningful conclusions. OBJECTIVE To evaluate the long-term outcomes of a large series of patients undergoing FSRT for both functional and nonfunctional pituitary adenomas with the Novalis system (Brain LAB, Heimstetten, Germany). METHODS Chart data for 75 consecutive patients undergoing FSRT for a pituitary tumor (21 functional and 54 nonfunctional adenomas) at our institution between January 2004 and June 2013 were reviewed. RESULTS Radiographic progression-free survival was 100% over a mean of 47.8 months of radiographic follow-up (range, 12.0-131.2 months). Hormonal normalization was seen in 69.2% of patients with functional adenomas after FSRT, whereas 30.8% experienced partial hormonal control. Mild, grade I acute adverse effects were observed during radiotherapy treatment in 36 patients (48%), and objective, persistent worsening of vision occurred in a single patient (1.5%) after FSRT. New hormonal deficits were seen in 28.0% of patients after FSRT. Radiographic responses were inversely related to tumor volume. CONCLUSION FSRT delivers radiographic and functional outcomes similar to those seen with stereotactic radiosurgery and conventional radiotherapy with less resultant toxicity. FSRT is most beneficial for smaller tumors (those <3 cm in diameter).

scholarly journals Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
M. Doknić ◽  
S. Pekić ◽  
D. Miljić ◽  
I. Soldatović ◽  
V. Popović ◽  
...  
Keyword(s):  
Head Trauma ◽  
Pituitary Adenomas ◽  
Hemorrhagic Fever ◽  
Cranial Irradiation ◽  
Population Based ◽  
Cross Sectional ◽  
Pituitary Dysfunction ◽  
Tertiary Center ◽  
Common Causes ◽  
Nonfunctional Pituitary Adenomas

There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18–82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40.5%), congenital causes in 74 pts (14.6%), while acromegaly and prolactinomas were presented in 37 (7.2%) and 36 (7.0%) patients, respectively. Craniopharyngiomas were detected in 30 pts (5.9%), and head trauma due to trauma brain injury-TBI and subarachnoid hemorrhage-SAH in 27 pts (5.4%). Survivors of hemorrhagic fever with renal syndrome (HFRS) and those with previous cranial irradiation were presented in the same frequency (18 pts, 3.5% each). Conclusion. The most common causes of hypopituitarism in our database are pituitary adenomas. Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database.

scholarly journals Neuroendoscopic and microscopic transsphenoidal approach for resection of nonfunctional pituitary adenomas

2019 ◽  
Vol 7 (13) ◽  
pp. 1591-1598 ◽  
Author(s):  
Zhi-Quan Ding ◽  
Sheng-Fan Zhang ◽  
Qing-Hua Wang
Keyword(s):  
Pituitary Adenomas ◽  
Transsphenoidal Approach ◽  
Nonfunctional Pituitary Adenomas

scholarly journals Novel Molecular Signaling and Classification of Human Clinically Nonfunctional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses

2005 ◽  
Vol 65 (22) ◽  
pp. 10214-10222 ◽  
Author(s):  
Carlos S. Moreno ◽  
Chheng-Orn Evans ◽  
Xianquan Zhan ◽  
Mammerhi Okor ◽  
Dominic M. Desiderio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Pituitary Adenomas ◽  
Molecular Signaling ◽  
Nonfunctional Pituitary Adenomas ◽  
Proteomic Analyses

Correlation between the Expression of Interleukin-6, STAT3, E-Cadherin and N-Cadherin Protein and Invasiveness in Nonfunctional Pituitary Adenomas

2019 ◽  
Author(s):  
Xiaoxu Shen ◽  
Qi Liu ◽  
Jian Xu ◽  
Yang Wang
Keyword(s):  
Pituitary Adenoma ◽  
Correlation Analysis ◽  
Pituitary Adenomas ◽  
Signal Transducer ◽  
Epithelial Cadherin ◽  
Nonfunctional Pituitary Adenomas ◽  
Transcription 3 ◽  
Spearman’S Correlation ◽  
E Cadherin

Abstract Objective This study aimed to investigate the expression of interleukin (IL)-6, signal transducer and activator of transcription 3 (STAT3), epithelial-cadherin (E- cadherin) and neural-cadherin (N-cadherin) proteins in nonfunctional pituitary adenomas, and their correlation with invasiveness. Method Thirty cases of nonfunctional pituitary adenoma pathological wax specimens were selected from our hospital, including 20 cases of invasive nonfunctional pituitary adenoma (INFPA) and 10 noninvasive nonfunctional pituitary adenomas (NNFPAs). Envision was used to detect IL-6, STAT3, E-cadherin , and N-cadherin in specimens. Statistical methods were used to analyze the correlation between the four proteins and the Knosp classification of nonfunctional pituitary adenomas. Result IL-6 and STAT3 were highly expressed in INFPAs but poorly expressed in NNFPAs. E-cadherin expression in INFPAs was lower than that in NNFPAs. N-cadherin was positive or strongly positive in both groups. Spearman's correlation analysis showed that the expression of IL-6 and STAT3 was positively correlated with Knosp's classification, whereas the expression of E-cadherin was negatively correlated with Knosp classification. Meanwhile, the expression of N-cadherin was not correlated with Knosp's classification. Conclusion The expression of the IL-6, STAT3, E-cadherin proteins were associated nonfunctional pituitary adenomas. However, the expression of N-cadherin was not correlated with nonfunctional pituitary adenomas.

scholarly journals Heterogeneity analysis of the proteomes in clinically nonfunctional pituitary adenomas

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Xianquan Zhan ◽  
Xiaowei Wang ◽  
Ying Long ◽  
Dominic M Desiderio
Keyword(s):  
Pituitary Adenomas ◽  
Nonfunctional Pituitary Adenomas ◽  
Heterogeneity Analysis

4 Functional and Nonfunctional Pituitary Adenomas

2019 ◽  
pp. 47-60
Author(s):  
Ankush Chandra ◽  
Manish K. Aghi
Keyword(s):  
Pituitary Adenomas ◽  
Nonfunctional Pituitary Adenomas

Hypermethylation of thep16/CDKN2A/MTS1 gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas

1999 ◽  
Vol 24 (4) ◽  
pp. 328-336 ◽  
Author(s):  
David J. Simpson ◽  
John E. Bicknell ◽  
Anne Marie McNicol ◽  
Richard N. Clayton ◽  
William E. Farrell
Keyword(s):  
Protein Expression ◽  
Pituitary Adenomas ◽  
Mts1 Gene ◽  
Nonfunctional Pituitary Adenomas
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