scholarly journals Principles and Applications of Nanoplasmonics in Biological and Chemical Sensing: A Review

2020 ◽  
Author(s):  
Parsoua A. Sohi ◽  
Mojtaba Kahrizi
Keyword(s):  
Optical Sensors ◽  
Label Free ◽  
Crystal Fiber ◽  
Prism Coupler ◽  
Sensing Applications ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Sensitivity Improvement ◽  
Device Sensitivity ◽  
Non Destructive

Biosensing requires a highly sensitive real-time detection of the biomolecules. These properties are granted by nanoplasmonic sensing techniques. SPR-based optical sensors have evolved as a sensitive and versatile biosensing tool. A growing number of SPR-based sensing applications in the solution of clinical problems are reported in the recent years. This refers to the point that these sensors provide label-free detection of the living cells and non-destructive analysis techniques. In this study, we will review the mechanism of the detection in SPR biosensing, followed by the methods used to develop sensors to detect gases and the chemical, biological, and molecular interaction. The device sensitivity improvement based on plasmonic effects is also addressed in this study, and accordingly, the size and material dependence of the resonance frequency are discussed. The reviewed articles are categorized into three groups, depending on the SPR excitation configuration. In the first group of the sensors, the sensitivity of LSPR-based sensors in prism coupler configurations is reviewed. The second group, SPR excitation by optical fiber, slightly improved the sensitivity of the detections. The unique capability of the third group, photonic crystal fiber SPR sensors, in providing greatly improved sensitivity, generated a vast field of researches and applications in biosensing devices.

Design of Photonic Crystals Waveguide Using Microfluidic Infiltration

2014 ◽  
Vol 492 ◽  
pp. 301-305 ◽  
Author(s):  
Faida Bougriou ◽  
Touraya Boumaza ◽  
Mohamed Bouchemat
Keyword(s):  
Photonic Crystals ◽  
Fdtd Method ◽  
High Sensitivity ◽  
Slab Waveguide ◽  
Label Free ◽  
Single Chip ◽  
Photonic Crystal Slab ◽  
Sensing Applications ◽  
Highly Sensitive ◽  
Label Free Detection

The use of photonic crystals (PCS) in biosensor applications has lead to the development of highly sensitive and selective microfluidic sensor elements. Two main advantages of these devices for sensing applications are their high sensitivity and their reduced size, which makes it possible, in one hand, to detect very small analytes without the need of markers (label-free detection), and to integrate many of these devices on a single chip to perform a multi-parameter detection on the other hand. In the present paper, we analyze the design of a highly sensitive microfluidic sensors based on 2D photonic crystal slab waveguide formed by increasing the radii of air holes localized at each side of the line defect and filling with homogenous de-ionized water (nc =1.33). The transmission spectrum of the sensor has been obtained with the use of Finite Difference Time Domain (FDTD) method and it has been observed that a 306 nm wavelength position of the lower band edge shift was observed corresponding to a sensitivity of more than 927 nm per refractive index unit (RIU). Development of microfluidic sensor designs that enhance sensitivity is especially important because it allows detection of lower concentrations of analytes.

Target-induced structure switching of DNA for label-free and ultrasensitive electrochemiluminescent detection of proteins

2014 ◽  
Vol 50 (24) ◽  
pp. 3211-3213 ◽  
Author(s):  
Mengli Yang ◽  
Ying Chen ◽  
Yun Xiang ◽  
Ruo Yuan ◽  
Yaqin Chai
Keyword(s):  
Dna Structure ◽  
Label Free ◽  
Switching Strategy ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Exo Iii ◽  
Recycling Amplification ◽  
Structure Switching ◽  
Induced Structure

Highly sensitive and label-free detection of thrombin is achieved via a target-induced DNA structure switching strategy and Exo III-assisted recycling amplification.

scholarly journals Highly Sensitive Sensors Based on Photonic Crystal Fiber Modal Interferometers

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Joel Villatoro ◽  
Vittoria Finazzi ◽  
Gonçal Badenes ◽  
Valerio Pruneri
Keyword(s):  
Photonic Crystal ◽  
Photonic Crystal Fiber ◽  
Thermal Sensitivity ◽  
Post Processing ◽  
Crystal Fiber ◽  
Sensing Applications ◽  
Highly Sensitive ◽  
Volatile Organic ◽  
Processing Techniques ◽  
Highly Sensitive Sensors

We review the research on photonic crystal fiber modal interferometers with emphasis placed on the characteristics that make them attractive for different sensing applications. The fabrication of such interferometers is carried out with different post-processing techniques such as grating inscription, tapering or cleaving, and splicing. In general photonic crystal fiber interferometers exhibit low thermal sensitivity while their applications range from sensing strain or temperature to refractive index and volatile organic compounds.

scholarly journals Dual-Cavity Triple-Metal Gate-Underlap Dielectric-Modulated Charge-Plasma-based TFET for the Biomolecules Recognition

2021 ◽  
Author(s):  
Abhijeet Sahu ◽  
Mamta Khosla ◽  
Neetu Sood ◽  
Girish Wadhwa
Keyword(s):  
Drain Current ◽  
Transfer Characteristic ◽  
Label Free ◽  
Metal Gate ◽  
Sensing Applications ◽  
High K ◽  
Label Free Detection ◽  
Silvaco Atlas ◽  
K 12 ◽  
Gate Underlap

In this era of technology, biosensors play an essential role in living life. Today’s research and investigation revolved around its higher responsiveness and speed of detection. Normal TFET has many disadvantages like fabrication complexity, random dopant fluctuation, and the lower ON-State current. We are introducing a device that is a Dual-Cavity Triple-Metal gate-underlap DM-CPTFET for label-free detection. This device has a dual cavity for sensing different types of biomolecules simultaneously. We used the tool i.e SILVACO ATLAS TCAD Simulator for the sensing applications. High K material and gate work function engineering help us to improve drain current and better sensitivity. We used this TCAD tool, for analyzing the different parameter variations like energy band variation, surface potential, transfer characteristic, and output characteristic using different biomolecules Gelatin(k=12), Keratin(K=8), Biotin(K=2.63), etc.

scholarly journals The label-free detection and distinction of CYP2C9-expressing and non-expressing cells by surface-enhanced Raman scattering substrates based on bimetallic AuNPs–AgNWs

RSC Advances ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 13304-13315 ◽  
Author(s):  
Xiaowei Cao ◽  
Shuai Chen ◽  
Zhenyu Wang ◽  
Yong Liu ◽  
Xiaowei Luan ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Silicon Wafer ◽  
Surface Enhanced Raman Scattering ◽  
Cellular Composition ◽  
Label Free ◽  
Label Free Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Non Destructive

A AuNPs–AgNWs decorated silicon wafer was used as a non-destructive and label-free tool in SERS spectroscopy to detect and distinguish the cellular composition of CYP2C9-expressing cells (293T-Mig-2C9) and non-expressing cells (293T-Mig-R1).

Nanografting of Polymer Brushes on Gold Substrate by RAFT-RIGP

2021 ◽  
Vol 7 (1) ◽  
pp. 5
Author(s):  
Bin Jeremiah D. Barba ◽  
Patricia Nyn L. Heruela ◽  
Patrick Jay E. Cabalar ◽  
John Andrew A. Luna ◽  
Allan Christopher C. Yago ◽  
...  
Keyword(s):  
Surface Plasmon ◽  
Optical Sensors ◽  
Self Assembly ◽  
Polymer Brushes ◽  
Incident Light ◽  
Organosulfur Compounds ◽  
Layer By Layer ◽  
Label Free ◽  
Sensing Applications ◽  
Wide Range

Optical sensors based on surface plasmon resonance (SPR) have made great strides in the detection of various chemical and biological analytes. A surface plasmon is a bound, non-radiative evanescent wave generated as resonant electrons on a metal–dielectric surface to absorb energy from an incident light. As analytes bind to a functionalized metal substrate, the refractometric response generated can be used for quantitation with great selectivity, sensitivity, and capacity for label-free real-time analysis. Polymer nanobrushes are ideal recognition elements because of their greater surface area and their wide range of functional versatility. Here, we introduce a simple “grafting-from” method to covalently attach nanometer-thick polymer chains on a gold surface. Nanografting on gold-coated BK-7 glass was performed in two steps: (1) self-assembly of organosulfur compounds; and (2) RAFT-mediated radiation-induced graft polymerization (RAFT-RIGP) of polyglycidyl methacrylate (PGMA). Surface modification was monitored and verified using FTIR and SPR. Layer-by-layer thickness calculated based on Winspall 3.02 simulation fitted with experimental SPR curves showed successful self-assembly of 1-dodecanethiol (DDT) monolayer with thickness measuring 1.4 nm. These alkane chains of DDT served as the graft initiation sites for RAFT-RIGP. Nanografting was controlled by adjusting the absorbed dose in the presence of chain transfer agent, 4-cyano-4-(phenylcarbonothioylthio)pentanoic acid. The molecular weight of grafted polymers measuring 2.8 and 4.3 kDa corresponded to a thickness increase of 3.6 and 7.9 nm, respectively. These stable nanografted gold substrates may be further functionalized for sensing applications.

Finite Element Method-based Design and Simulations of Micro-cantilever Platform for Chemical and Bio-sensing Applications

2016 ◽  
Vol 66 (5) ◽  
pp. 485 ◽  
Author(s):  
R. Agarwal ◽  
R. Mukhiya ◽  
R. Sharma ◽  
M.K. Sharma ◽  
A.K. Goel
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Label Free ◽  
Device Structure ◽  
Micro Electro Mechanical Systems ◽  
Sensing Applications ◽  
Toxic Agents ◽  
Label Free Detection ◽  
Micro Cantilever ◽  
Element Method

Micro-electro-mechanical systems (MEMS)-based cantilever platform have capability for the detection of chemical and biological agents. This paper reports about the finite element method (FEM) based design and simulations of MEMS-based piezoresistor cantilever platform to be used for detection of chemical and biological toxic agents. Bulk micromachining technique is adopted for the realisation of the device structure. MEMS piezoresistive biosensing platforms are having potential for a field-based label-free detection of various types of bio-molecules. Using the MEMMECH module of CoventorWare® simulations are performed on the designed model of the device and it is observed that principal stress is maximum along the length (among other dimensions of the micro-cantilever) and remains almost constant for 90 per cent of the length of the micro-cantilever. The dimensions of piezoresistor are optimised and the output voltage vs. stress analysis for various lengths of the piezoresistor is performed using the MEMPZR module of the CoventorWare®.

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