scholarly journals Dual-Cavity Triple-Metal Gate-Underlap Dielectric-Modulated Charge-Plasma-based TFET for the Biomolecules Recognition

2021 ◽  
Author(s):  
Abhijeet Sahu ◽  
Mamta Khosla ◽  
Neetu Sood ◽  
Girish Wadhwa
Keyword(s):  
Drain Current ◽  
Transfer Characteristic ◽  
Label Free ◽  
Metal Gate ◽  
Sensing Applications ◽  
High K ◽  
Label Free Detection ◽  
Silvaco Atlas ◽  
K 12 ◽  
Gate Underlap

In this era of technology, biosensors play an essential role in living life. Today’s research and investigation revolved around its higher responsiveness and speed of detection. Normal TFET has many disadvantages like fabrication complexity, random dopant fluctuation, and the lower ON-State current. We are introducing a device that is a Dual-Cavity Triple-Metal gate-underlap DM-CPTFET for label-free detection. This device has a dual cavity for sensing different types of biomolecules simultaneously. We used the tool i.e SILVACO ATLAS TCAD Simulator for the sensing applications. High K material and gate work function engineering help us to improve drain current and better sensitivity. We used this TCAD tool, for analyzing the different parameter variations like energy band variation, surface potential, transfer characteristic, and output characteristic using different biomolecules Gelatin(k=12), Keratin(K=8), Biotin(K=2.63), etc.

Impact of interface trap charges on Junctionless double and triple metal gate High-k Gate All Around Nanowire FET based Alzheimer Biosensor

2021 ◽  
Author(s):  
Rishu Chaujar ◽  
Mekonnen Getnet Yirak
Keyword(s):  
Threshold Voltage ◽  
Positive Impact ◽  
Drain Current ◽  
Interface Trap ◽  
Metal Gate ◽  
High K ◽  
Current Threshold ◽  
Subthreshold Voltage ◽  
Output Characteristics ◽  
The Impact

Abstract In this work, junctionless double and triple metal gate high-k gate all around nanowire field-effect transistor-based APTES biosensor has been developed to study the impact of ITCs on device sensitivity. The analytical results were authenticated using ‘‘ATLAS-3D’’ device simulation tool. Effect of different interface trap charge on the output characteristics of double and triple metal gate high-k gate all around junctionless NWFET biosensor was studied. Output characteristics, like transconductance, output conductance,drain current, threshold voltage, subthreshold voltage and switching ratio, including APTES biomolecule, have been studied in both devices. 184% improvement has been investigated in shifting threshold voltage in a triple metal gate compared to a double metal gate when APTES biomolecule immobilizes on the nanogap cavity region under negative ITCs. Based on this finding, drain off-current ratio and shifting threshold voltage were considered as sensing metrics when APTES biomolecule immobilizes in the nanogap cavity under negative ITCs which is significant for Alzheimer's disease detection. We signifies a negative ITC has a positive impact on our proposed biosensor device compared to positive and neutral ITCs.

Label-free detection of serum uric acid using novel high-k Sm2TiO5 membrane-based electrolyte–insulator–semiconductor

2010 ◽  
Vol 146 (1) ◽  
pp. 342-348 ◽  
Author(s):  
Min-Hsien Wu ◽  
Tsung-Wu Lin ◽  
Ming-De Huang ◽  
Hsin-Yao Wang ◽  
Tung-Ming Pan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Label Free ◽  
High K ◽  
Label Free Detection

Finite Element Method-based Design and Simulations of Micro-cantilever Platform for Chemical and Bio-sensing Applications

2016 ◽  
Vol 66 (5) ◽  
pp. 485 ◽  
Author(s):  
R. Agarwal ◽  
R. Mukhiya ◽  
R. Sharma ◽  
M.K. Sharma ◽  
A.K. Goel
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Label Free ◽  
Device Structure ◽  
Micro Electro Mechanical Systems ◽  
Sensing Applications ◽  
Toxic Agents ◽  
Label Free Detection ◽  
Micro Cantilever ◽  
Element Method

Micro-electro-mechanical systems (MEMS)-based cantilever platform have capability for the detection of chemical and biological agents. This paper reports about the finite element method (FEM) based design and simulations of MEMS-based piezoresistor cantilever platform to be used for detection of chemical and biological toxic agents. Bulk micromachining technique is adopted for the realisation of the device structure. MEMS piezoresistive biosensing platforms are having potential for a field-based label-free detection of various types of bio-molecules. Using the MEMMECH module of CoventorWare® simulations are performed on the designed model of the device and it is observed that principal stress is maximum along the length (among other dimensions of the micro-cantilever) and remains almost constant for 90 per cent of the length of the micro-cantilever. The dimensions of piezoresistor are optimised and the output voltage vs. stress analysis for various lengths of the piezoresistor is performed using the MEMPZR module of the CoventorWare®.

Phosphate-dependent DNA Immobilization on Hafnium Oxide for Bio-Sensing Applications

2009 ◽  
Vol 1191 ◽  
Author(s):  
Nicholas M Fahrenkopf ◽  
Serge Oktyabrsky ◽  
Eric Eisenbraun ◽  
Magnus Bergkvist ◽  
Hua Shi ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Hafnium Oxide ◽  
Dielectric Material ◽  
Field Effect Transistors ◽  
Leading Edge ◽  
High Sensitivity ◽  
Cmos Technology ◽  
Label Free ◽  
Sensing Applications ◽  
Label Free Detection

AbstractHafnium(IV) oxide (HfO2) has replaced silicon oxide as a gate dielectric material in leading edge CMOS technology, providing significant improvement in gate performance for field effect transistors (FETs). We are currently exploring this high-k dielectric for its use in nucleic acid-based FET biosensors. Due to its intrinsic negative charge, label-free detection of DNA can be achieved in the gate region of high-sensitivity FET devices. Previous work has shown that phosphates and phosphonates coordinate specifically onto metal oxide substrates including aluminum and titanium oxides. This property can therefore be exploited for direct immobilization of biomolecules such as nucleic acids. Our work demonstrates that 5’ phosphate-terminated single stranded DNA (ssDNA) can be directly immobilized onto HfO2 surfaces, without the need for additional chemical modification or crosslinking. Non-phosphorylated ssDNA does not form stable surface interactions with HfO2, indicating that immobilization is dependent upon the 5’ terminal phosphate. Further work has shown that surface immobilized ssDNA can be hybridized to complementary target DNA and that sequence-based hybridization specificity is preserved. These results suggest that the direct DNA-HfO2 immobilization strategy can enable nucleic acid-based biosensing assays on HfO2 terminated surfaces. This work will further enable high sensitivity electrical detection of biological targets utilizing transistor-based technologies.

scholarly journals Sensitivity Analysis of Junction Free Electrostatically Doped Tunnel-FET Based Biosensor

2021 ◽  
Author(s):  
Mukesh Kumar Bind ◽  
Kaushal Nigam
Keyword(s):  
Gate Dielectric ◽  
Dielectric Material ◽  
Transfer Characteristic ◽  
Dielectric Constants ◽  
Field Energy ◽  
Label Free ◽  
Charge Densities ◽  
Tunneling Mechanism ◽  
K 12 ◽  
First Time

Abstract The electrostatic doping technique has the ability to reduce random dopant fluctuations (RDFs), fabrication complexity and high thermal budget requirement in the fabrication process of nano-scale devices. In this paper, first time propose and simulate a Junction Free Electrostatically Doped Tunnel Field-Effect Transistor (JFED- TFET) based biosensor for label-free biosensing applications. The gate dielectric modulation concept used for sensing the existence of biomolecules inside the nano-cavity, created in gate dielectric material towards the tunneling junction to modulate the tunneling mechanism. The sensitivity of JF-ED-TFET biosensor investigate with various types of biomolecules based on dielectric constants (k) and charge densities (ρ). The sensing response of the JF-ED-TFET biosensor analyze in terms of electric field, energy band and transfer characteristic and the sensitivity in terms of ION, ION/IOFF ratio and Subtheshold Swing. The sensitivity of device investigated based on practical challenges as different filling factor and step-profile generated from the steric hinderance. The effect of temperate and nano-cavity dimensions variation on device performance also has been analyzed. In this work, various types of biomolecules as Streptavidin (k = 2.1), Ferro-cytochrome c (k = 4.7), keratin (k = 8) and Gelatin (k = 12) has been considered for the performance investigation.

scholarly journals Distinguishing dopamine and calcium responses using XNA-nanotube sensors for improved neurochemical sensing

2021 ◽  
Author(s):  
Alice J. Gillen ◽  
Alessandra Antonucci ◽  
Melania Reggente ◽  
Daniel Morales ◽  
Ardemis A. Boghossian
Keyword(s):  
Neurological Diseases ◽  
Locked Nucleic Acid ◽  
Optical Biosensors ◽  
Label Free ◽  
Sensing Applications ◽  
Label Free Detection ◽  
Improved Stability ◽  
New Applications

AbstractTo date, the engineering of single-stranded DNA-SWCNT (DNA-SWCNT) optical biosensors have largely focused on creating sensors for new applications with little focus on optimising existing sensors for in vitro and in vivo conditions. Recent studies have shown that nanotube fluorescence can be severely impacted by changes in local cation concentrations. This is particularly problematic for neurotransmitter sensing applications as spatial and temporal fluctuations in the concentration of cations, such as Na+, K+, or Ca2+, play a central role in neuromodulation. This can lead to inaccuracies in the determination of neurotransmitter concentrations using DNA-SWCNT sensors, which limits their use for detecting and treating neurological diseases.Herein, we present new approaches using locked nucleic acid (LNA) to engineer SWCNT sensors with improved stability towards cation-induced fluorescence changes. By incorporating LNA bases into the (GT)15-DNA sequence, we create sensors that are not only more resistant towards undesirable fluorescence modulation in the presence of Ca2+ but that also retain their capabilities for the label-free detection of dopamine. The synthetic biology approach presented in this work therefore serves as a complementary means for enhancing nanotube optoelectronic behavior, unlocking previously unexplored possibilities for developing nano-bioengineered sensors with augmented capabilities.

scholarly journals Analytical Modelling of Dielectric Modulated Negative Capacitance MoS2-FET for Biosensor Application

2021 ◽  
Author(s):  
Deepak Kumar Panda ◽  
Rajan Singh ◽  
Trupti Lenka ◽  
Vishal Goyal ◽  
Nour El I Boukortt ◽  
...  
Keyword(s):  
Drain Current ◽  
Ferroelectric Materials ◽  
Oxide Material ◽  
Negative Capacitance ◽  
Label Free ◽  
Subthreshold Region ◽  
Enhanced Sensitivity ◽  
Label Free Detection ◽  
Biosensor Application ◽  
Detection Of Biomolecules

In this paper, a dielectric modulated negative capacitance (NC)-MoS<sub>2</sub> field effect transistor (FET)-based biosensor is proposed for label-free detection of biomolecules such as enzymes, proteins, DNA, etc. Various reports present experimental demonstration and modelling of NC-MoS<sub>2</sub> FET, but it is never utilized as a dielectric modulated biosensor. Therefore, in this work, the modelling, characterization and sensitivity analysis of dielectric modulated NC-MoS<sub>2</sub> FET is focussed. For immobilization of biomolecules, a nanocavity is formed below the gate by etching some portion of the gate oxide material. The immobilization of biomolecules in the cavity leads to a variation of different electrostatic properties such as surface potential, threshold voltage, drain current, and subthreshold-swing (SS) which can be utilized as sensing parameters. An analytical model for the proposed biosensor is also developed in the subthreshold region by considering the properties of two-dimensional (2D) ferroelectric materials and benchmarked with TCAD device simulations. The effect of change of gate length and doping concentration on different electrical properties is also analysed to estimate the optimum value of channel doping. The results prove that the proposed device can be used for next-generation low power label-free biosensor which shows enhanced sensitivity as compared to traditional FET-based biosensors.

Design of Photonic Crystals Waveguide Using Microfluidic Infiltration

2014 ◽  
Vol 492 ◽  
pp. 301-305 ◽  
Author(s):  
Faida Bougriou ◽  
Touraya Boumaza ◽  
Mohamed Bouchemat
Keyword(s):  
Photonic Crystals ◽  
Fdtd Method ◽  
High Sensitivity ◽  
Slab Waveguide ◽  
Label Free ◽  
Single Chip ◽  
Photonic Crystal Slab ◽  
Sensing Applications ◽  
Highly Sensitive ◽  
Label Free Detection

The use of photonic crystals (PCS) in biosensor applications has lead to the development of highly sensitive and selective microfluidic sensor elements. Two main advantages of these devices for sensing applications are their high sensitivity and their reduced size, which makes it possible, in one hand, to detect very small analytes without the need of markers (label-free detection), and to integrate many of these devices on a single chip to perform a multi-parameter detection on the other hand. In the present paper, we analyze the design of a highly sensitive microfluidic sensors based on 2D photonic crystal slab waveguide formed by increasing the radii of air holes localized at each side of the line defect and filling with homogenous de-ionized water (nc =1.33). The transmission spectrum of the sensor has been obtained with the use of Finite Difference Time Domain (FDTD) method and it has been observed that a 306 nm wavelength position of the lower band edge shift was observed corresponding to a sensitivity of more than 927 nm per refractive index unit (RIU). Development of microfluidic sensor designs that enhance sensitivity is especially important because it allows detection of lower concentrations of analytes.

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