Therapeutic Potential of IL-9 in Allergic and Autoimmune Diseases
Keyword(s):
T Cell
◽
Interleukin-9 (IL-9) is a pleiotropic cytokine produced by several immune and epithelial cells. Recently, many studies have eluded the physiological and pathological roles of IL-9 and its lineage-specific helper T cell subset (Th9). In this chapter, we will focus on the immunological role of Interleukin 9 (IL-9) in allergy and autoimmunity. We will introduce the basics of IL-9 and describe the cells involved in the secretion, signaling, and regulation of IL-9. After establishing the background, we will discuss the pathogenesis and regulation of IL-9 in allergic and autoimmune diseases. We will conclude the chapter by providing an updated therapeutics that target IL-9 and their potential uses in autoimmune and allergic diseases.
1988 ◽
Vol 102
(1)
◽
pp. 77-105
◽
1987 ◽
Vol 82
(suppl 1)
◽
pp. 260-273
◽
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice
2021 ◽
Vol 118
(23)
◽
pp. e2103730118
1998 ◽
Vol 9
(2)
◽
pp. 139-151
◽
1993 ◽
Vol 23
(6)
◽
pp. 1378-1380
◽