scholarly journals Vitamin E in Human Skin: Functionality and Topical Products

2021 ◽  
Author(s):  
Claudineia Aparecida Sales de Oliveira Pinto ◽  
Tércio Elyan Azevedo Martins ◽  
Renata Miliani Martinez ◽  
Thamires Batello Freire ◽  
Maria Valéria Robles Velasco ◽  
...  
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Human Skin ◽  
Antioxidant System ◽  
Topical Application ◽  
Uvb Radiation ◽  
Topical Formulations ◽  
Risk Of Cancer

Vitamins are part of the antioxidant system of human skin, and are detectable in different layers, so the topical application can be an alternative to maintain the functionality of the system. The capacity of the antioxidant gradient of keratinocytes is associated with attenuation of the action of related free radicals in both esthetics and health. These problems arise from extrinsic aging and are related to the risk of cancer. Vitamin E has been proven to have antioxidant and moisturizing properties in the skin and can protect against the damage of UVB radiation, with emphasis on the reduction of acute erythema and photoaging. The choice for the use of topical vitamin E, compared to the oral is given by the safety as mild irritation and it has potential for multifunctional topical formulations. The purpose of the chapter is to review the topical use of formulations with vitamin E, addressing the development, safe use and evaluation of effectiveness.

Evaluation of the Local Effects of Vitamin E ( E-Mousse®) on Free Radicals in Diabetic Microangiopathy: A Randomized, Controlled Trial

Angiology ◽  
2003 ◽  
Vol 54 (4) ◽  
pp. 415-421 ◽  
Author(s):  
I. Ruffini ◽  
G. Belcaro ◽  
M.R. Cesarone ◽  
G. Geroulakos ◽  
A. Di Renzo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Free Radicals ◽  
Vitamin E ◽  
Controlled Trial ◽  
Diabetic Microangiopathy ◽  
Local Effects ◽  
Randomized Controlled

Enhanced optical clearing of human skin at topical application of immersion agents to stratum corneum pretreated by a lattice-like photothermal ablation

2006 ◽  
Author(s):  
Valery V. Tuchin ◽  
Gregory B. Altshuler ◽  
Anna A. Gavrilova ◽  
Alexander B. Pravdin ◽  
David Tabatadze ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Skin ◽  
Topical Application ◽  
Optical Clearing ◽  
Photothermal Ablation

scholarly journals Enhanced Transdermal Delivery of Pranoprofen Using a Thermo-Reversible Hydrogel Loaded with Lipid Nanocarriers for the Treatment of Local Inflammation

2021 ◽  
Vol 15 (1) ◽  
pp. 22
Author(s):  
María Rincón ◽  
Marcelle Silva-Abreu ◽  
Lupe Carolina Espinoza ◽  
Lilian Sosa ◽  
Ana Cristina Calpena ◽  
...  
Keyword(s):  
Human Skin ◽  
Topical Application ◽  
Topical Treatment ◽  
Transdermal Delivery ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vitro Release ◽  
Heterogeneous Structure ◽  
Clinical Environment ◽  
Local Skin

A biocompatible topical thermo-reversible hydrogel containing Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs) was studied as an innovative strategy for the topical treatment of skin inflammatory diseases. The PF-NLCs-F127 hydrogel was characterized physiochemically and short-time stability tests were carried out over 60 days. In vitro release and ex vivo human skin permeation studies were carried out in Franz diffusion cells. In addition, a cytotoxicity assay was studied using the HaCat cell line and in vivo tolerance study was performed in humans by evaluating the biomechanical properties. The anti-inflammatory effect of the PF-NLCs-F127 was evaluated in adult male Sprague Daw-ley® rats using a model of inflammation induced by the topical application of xylol for 1 h. The developed PF-NLCs-F127 exhibited a heterogeneous structure with spherical PF-NLCs in the hydrogel. Furthermore, a thermo-reversible behaviour was determined with a gelling temperature of 32.5 °C, being close to human cutaneous temperature and thus favouring the retention of PF. Furthermore, in the ex vivo study, the amount of PF retained and detected in human skin was high and no systemic effects were observed. The hydrogel was found to be non-cytotoxic, showing cell viability of around 95%. The PF-NLCs-F127 is shown to be well tolerated and no signs of irritancy or alterations of the skin’s biophysical properties were detected. The topical application of PF-NLCs-F127 hydrogel was shown to be efficient in an inflammatory animal model, preventing the loss of stratum corneum and reducing the presence of leukocyte infiltration. The results from this study confirm that the developed hydrogel is a suitable drug delivery carrier for the transdermal delivery of PF, improving its dermal retention, opening the possibility of using it as a promising candidate and safer alternative to topical treatment for local skin inflammation and indicating that it could be useful in the clinical environment.

The Effects of Thyme Tea Supplement on Free Radicals Formation and Antioxidant System of Elite Wrestlers

2013 ◽  
Vol 12 (5) ◽  
pp. 433-440
Author(s):  
C. Berkan Alpay ◽  
Serkan Hazar ◽  
Kadir Gokdemir ◽  
Nevin Atalay Guzel ◽  
Aymelek Gonenc ◽  
...  
Keyword(s):  
Free Radicals ◽  
Antioxidant System
Sign in / Sign up

Export Citation Format

Share Document