scholarly journals Metal Catalyzed Oxidation Reactions of Alkenes Using Eco-Friendly Oxidants

2021 ◽  
Author(s):  
Jay Soni ◽  
Pankaj Teli ◽  
Nusrat Sahiba ◽  
Ayushi Sethiya ◽  
Shikha Agarwal
Keyword(s):  
Organic Synthesis ◽  
Low Cost ◽  
Oxidation Reactions ◽  
Reaction Condition ◽  
Solid Waste Generation ◽  
Metal Catalyzed Oxidation ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation ◽  
New Strategies

Oxidation of alkenes is an important reaction in academia, industry and science as it is used to develop epoxides, carbonyls, allylic compounds, 1,2-diols, etc. Metal catalyzed oxidation of alkenes has aroused as a significant tool in modern organic synthesis. Several techniques are available; however some of them suffer from few shortcomings viz. high cost, toxic nature, harsh reaction condition, solid waste generation, etc. In view of these drawbacks, green oxidants i.e. O2, H2O2, TBHP, etc. have shown noteworthy prospects due to their nature, low cost, high atom economy and high sustainability in metal catalyzed reactions. This chapter highlights the metal catalyzed green oxidation of alkenes and shall provide new strategies for the functionalization and transformation of alkenes.

scholarly journals Scleroderma Autoantigens Are Uniquely Fragmented by Metal-catalyzed Oxidation Reactions: Implications for Pathogenesis

1997 ◽  
Vol 185 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Livia Casciola-Rosen ◽  
Fredrick Wigley ◽  
Antony Rosen
Keyword(s):  
Reactive Oxygen Species ◽  
Ischemia Reperfusion ◽  
Reactive Oxygen ◽  
Autoimmune Response ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Oxidation Reactions ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation

The observation that revelation of immunocryptic epitopes in self antigens may initiate the autoimmune response has prompted the search for processes which induce novel fragmentation of autoantigens as potential initiators of autoimmunity. The reversible ischemia reperfusion which characterizes scleroderma has focused attention on reactive oxygen species as molecules which might induce autoantigen fragmentation. We demonstrate that several of the autoantigens targeted in diffuse scleroderma are uniquely susceptible to cleavage by reactive oxygen species, in a metal-dependent manner. Multiple features of the fragmentation reaction and its inhibition indicate that these autoantigens possess metal-binding sites, which focus metal-catalyzed oxidation reactions (and consequent fragmentation) to specific regions of the antigens. These data suggest that the autoantibody response in scleroderma is the immune marker of unique protein fragmentation, induced by ischemia reperfusion in the presence of appropriate metals, and focus attention on abnormal metal status as a potential pathogenic principle in this disease.

Nanoreactors Technology in Green Organic Synthesis

2017 ◽  
Vol 14 (6) ◽  
pp. 810-864 ◽  
Author(s):  
Hamideh Aghahosseini ◽  
Ali Ramazani ◽  
Farideh Gouranlou ◽  
Sang Woo Joo
Keyword(s):  
Organic Synthesis ◽  
Cascade Reactions ◽  
Allylic Alcohol ◽  
Coupling Reactions ◽  
Oxidation Reactions ◽  
Promising Tool ◽  
Palladium Catalyzed ◽  
And Performance ◽  
Catalyzed Reactions ◽  
Metal Catalyzed

Background: Nanoreactors technology represents a promising tool for efficient and selective organic synthesis typically under “green” and sustainable reaction conditions. These structures with generating a confined reaction environment to accommodate that both reactants and catalysts can change the reaction pathways and induce new activities and selectivities. Objective: The paper reviews literature examples in which nanoreactors were employed in various types of organic and metal catalyzed reactions including multicomponent reactions, palladium-catalyzed coupling reactions, olefin metathesis, aza-Cope rearrangement, allylic alcohol isomerization, cyclization reactions, ring opening reactions, halogenation reactions, hydrolysis reactions, hydroformylation reactions, cascade reactions, addition reactions, oxidation reactions and reduction reactions. The reactions' survey is accompanied with the explanation of structure and performance of nanoreactors that are applied there. Conclusion: The availability of comprehensive information about the role of nanoreactors technology in green organic synthesis and investigation of different aspects of them such as their structures, mechanisms and synthetic utility can assist researchers in designing the greener approaches in organic synthesis.

Ambivalent role of ascorbic acid in the metal-catalyzed oxidation of oligopeptides

2021 ◽  
pp. 111510
Author(s):  
Nikolett Bodnár ◽  
Katalin Várnagy ◽  
Lajos Nagy ◽  
Gizella Csire ◽  
Csilla Kállay
Keyword(s):  
Ascorbic Acid ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation
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