scholarly journals Helicobacter pylori Infection: Regulatory T Cells and Their Participation in the Immune Response

2013 ◽  
Vol 6 (4) ◽  
Author(s):  
Tania Beatriz Romero-Adriàn ◽  
Jorymar Leal-Montiel
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells

scholarly journals Characteristics of Regulatory T cells

2016 ◽  
Vol 85 (4) ◽  
pp. 323-326
Author(s):  
Magdalena Frydrychowicz ◽  
Maciej Boruczkowski ◽  
Agata Kolecka-Bednarczyk ◽  
Renata Jenek ◽  
Joanna Rosołowska ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Adhesion Molecules ◽  
Chemokine Receptors ◽  
Toll Like Receptors ◽  
Effector Cells

Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-). CD25, CD45Ro, CD152, GITR, LAG-3, several adhesion molecules, chemokine receptors as well as Toll-like receptors are present on the surface of Treg. Mechanism of suppression used by nTreg is not completely understood.

In Vivo-Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response

2014 ◽  
Vol 6 (241) ◽  
pp. 241ra78-241ra78 ◽  
Author(s):  
S. Kasagi ◽  
P. Zhang ◽  
L. Che ◽  
B. Abbatiello ◽  
T. Maruyama ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells

Pd1(+) Regulatory T Cells Are Increased in Helicobacter pylori -Associated Gastritis

2011 ◽  
Vol 140 (5) ◽  
pp. S-470
Author(s):  
Miryam Calvino ◽  
Selma Benito-Martínez ◽  
Adrian G. McNicholl ◽  
Javier P. Gisbert ◽  
Trinidad Parra-Cid
Keyword(s):  
T Cells ◽  
Helicobacter Pylori ◽  
Regulatory T Cells

Analysis of regulatory T cells and CTLA-4 expression in pregnant women according to seropositivity to Toxoplasma gondii

Parasitology ◽  
2020 ◽  
Vol 147 (7) ◽  
pp. 810-815
Author(s):  
Karine Rezende-Oliveira ◽  
César Gómez-Hernández ◽  
Marcos Vinicius da Silva ◽  
Fernanda Rodrigues Helmo ◽  
Virmondes Rodrigues
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Toxoplasma Gondii ◽  
Regulatory T Cells ◽  
Pregnant Women ◽  
Positive Serology ◽  
Surface Molecules

AbstractPregnancy is considered a period in which immunomodulation occurs, although it is important for the maintenance of the foetus, could contribute to infections as Toxoplasma gondii. Immune response cells such as regulatory T cells participate in this immunomodulation, and surface molecules such as CTLA-4 develop an immunosuppressive role, could contribute to the establishment of the parasite. This study aimed to evaluate the presence of regulatory T cells and the expression of CTLA-4 in parturient and non-pregnant seropositive and seronegative for anti-T. gondii antibodies. Sixty-two participants were evaluated, 14 parturient with negative serology, 23 parturient with positive serology, 16 non-pregnant women seronegative and 9 non-pregnant women seropositive. Immunophenotyping was performed for characterize TCD4+Foxp3+ cells, T CD4+CD25-Foxp3+, TCD4+CD25highFoxp3+, TCD4+CTLA-4+, TCD4+CD25-CTLA-4+ and TCD4+CD25highCTLA-4+. We observed a lower level of CD4+CD25highFoxp3+ cells from seropositive parturient compared with seropositive non-pregnant cells. Significative levels of CD4+CD25-Foxp3+ cells from seronegative pregnant were observed compared with seropositive pregnant cells. Furthermore, the higher level of CD4+CD25-CTLA-4+ cells populations was detected in seropositive pregnant cells compared with seropositive non-pregnant. Although a significant increase in CTLA-4 cells was observed in pregnant women positive for anti-T. gondii antibodies, this increase did not cause a risk of reactivation of the infection.

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