scholarly journals A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 12 % GLYCOLIC ACID CREAM AND 10% AZELAIC ACID CREAM IN THE TREATMENT OF POST ACNE HYPERPIGMENTATION.

2021 ◽  
pp. 34-35
Author(s):  
Archana Rede ◽  
Sanjay N. Agrawal ◽  
Yoganand Kulkarni
Keyword(s):  
Comparative Study ◽  
Azelaic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Common Complication ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Post inflammatory hyperpigmentation is a most common complication seen after post acne. Therapeutic goal of treatment include promoting degradation of melanosomes and inhibiting their formation. Patient treated with Azelaic acid / Glycolic acid experienced of significant greater reduction in number of inflammatory lesions. This study focuses on the comparison of efficacy of 12% Glycolic acid and 10% Azelaic acid in treating post acne hyperpigmentation.

scholarly journals Efficacy of Dapsone 5% gel in treatment of Acne vulgaris

2016 ◽  
Vol 2 (4) ◽  
pp. 77
Author(s):  
Sugat A. Jawade ◽  
Adarshlata Singh
Keyword(s):  
Success Rate ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Inclusion Criteria ◽  
Pilosebaceous Unit ◽  
Open Label ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder ◽  
Medical College ◽  
Jawaharlal Nehru

<p class="abstract"><strong>Background:</strong> Acne vulgaris is chronic inflammatory disorder of pilosebaceous unit mainly characterized by comedones, papules and nodulocystic lesions affecting face and upper trunk. Topical dapsone 5% gel is approved to treat acne vulgaris because of its anti-inflammatory and anti-bacterial activities.</p><p class="abstract"><strong>Methods:</strong> A single center, open label interventional study was conducted during 1 year period in dermatology OPD of Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra. Patients were enrolled in the study considering inclusion criteria. Patients were asked to apply dapsone 5% gel twice daily on face for 12 week. Efficacy was evaluated by mean percent reduction in total, inflammatory and non-inflammatory lesions and success rate on change in investigator global acne severity assessment scale while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline, 1, 2, 4, 8 and 12 week.<strong></strong></p><p class="abstract"><strong>Results:</strong> At end of 12 week, success rate reached to 31.54%. Dapsone 5% gel was effective in reduction of total, non-inflammatory and inflammatory lesions by 57.75%, 52% and 63.1% respectively. Side effects with dapsone gel were tolerable, mild and transient.</p><p><strong>Conclusions:</strong> Dapsone 5% gel was efficacious and well tolerated in non-inflammatory as well as inflammatory acne lesions. </p>

Acne

2018 ◽  
Author(s):  
Ben Esdaile
Keyword(s):  
Hair Follicle ◽  
Sebaceous Gland ◽  
Acne Vulgaris ◽  
Psychological Effects ◽  
Inflammatory Disorder ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Severe Acne ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a common, chronic inflammatory disorder of the pilosebaceous unit (the hair follicle and accompanying sebaceous gland). It can be classified as mild, moderate, or severe. Mild acne is characterized by comedones (non-inflammatory lesions: ‘blackheads’ and ‘whiteheads’) being the predominant lesions. Papules and pustules may also be present but are few in number. Moderate acne is defined by more inflammatory lesions such as papules and pustules, with comedones also usually present. Severe acne is defined as widespread inflammatory lesions, nodules, cysts, and scarring. Moderate acne that has not settled within 6 months of treatment, or acne that is causing serious psychological effects, is also categorized as severe.

scholarly journals Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

2021 ◽  
pp. 2021063
Author(s):  
Surabhi Dayal ◽  
Satbir Singh ◽  
Priyadarshini Sahu
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Comparative Study ◽  
Clinical Efficacy ◽  
Trichloroacetic Acid ◽  
Acne Vulgaris ◽  
Efficacy And Safety ◽  
Inflammatory Lesions ◽  
Treatment Groups ◽  
Proven Efficacy

Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with goodsafety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in thetreatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 personseach, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluationof active acne was done by individual lesion counts (comedones, papules and pustules) and calculationof the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baselinevalues, without significant differences between the treatment groups. Thus, the peels had equivalentefficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions,while the SA peel was better for inflammatory lesions, but the differences were not significant. Noserious adverse effects were recorded, but more patients in the TCA peel group experienced burningand stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acnevulgaris, but safety and tolerability were better with the SA peel than TCA peel.

Efficacy and safety of a novel water‐soluble herbal patch for acne vulgaris treatment: a randomized, assessor‐blinds controlled, intra‐individual split‐face comparative study

2021 ◽  
Author(s):  
Kulwipapat Jaturapisanukul ◽  
Montree Udompataikul ◽  
Silada kanolrungsee ◽  
Salinee Rojhirunsakool ◽  
Nanticha kamanamool ◽  
...  
Keyword(s):  
Comparative Study ◽  
Acne Vulgaris ◽  
Water Soluble ◽  
Efficacy And Safety ◽  
Split Face

scholarly journals Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 567
Author(s):  
Ivona Tomić ◽  
Sandra Miočić ◽  
Ivan Pepić ◽  
Dubravka Šimić ◽  
Jelena Filipović-Grčić
Keyword(s):  
Azelaic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Adverse Event Rate ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
First Choice ◽  
In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris

2017 ◽  
Vol 17 (5) ◽  
pp. 797-801
Author(s):  
Jeong In Jae ◽  
Hyun Dong Ju ◽  
Kim Dong Hyun ◽  
Moon Soo Yoon ◽  
Hee Jung Lee
Keyword(s):  
Salicylic Acid ◽  
Acid Solution ◽  
Comparative Study ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Acid Ph

Jessner's solutionvs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild-to-moderate acne vulgaris

2016 ◽  
Vol 16 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Surabhi Dayal ◽  
Ashish Amrani ◽  
Priyadarshini Sahu ◽  
Vijay Kumar Jain
Keyword(s):  
Salicylic Acid ◽  
Comparative Study ◽  
Acne Vulgaris ◽  
Efficacy And Safety

scholarly journals COVID-19 and Sarcoidosis, Readiness for Vaccination: Challenges and Opportunities

2021 ◽  
Vol 8 ◽  
Author(s):  
Michael Manansala ◽  
Amit Chopra ◽  
Robert P. Baughman ◽  
Richard Novak ◽  
Elyse E. Lower ◽  
...  
Keyword(s):  
Clinical Decision ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Risk Of Infection ◽  
Decision Algorithm ◽  
Chronic Inflammatory Disorder ◽  
Immune Mediated ◽  
Immunosuppressive Medications ◽  
Increased Risk ◽  
Challenges And Opportunities

Sarcoidosis is an immune mediated chronic inflammatory disorder that is best characterized by non-caseating granulomas found in one or more affected organs. The COVID-19 pandemic poses a challenge for clinicians caring for sarcoidosis patients who may be at increased risk of infection compared to the general population. With the recent availability of COVID-19 vaccines, it is expected that clinicians raise questions regarding efficacy and safety in sarcoidosis. However, studies examining safety and efficacy of vaccines in sarcoidosis are lacking. In this review, we examine the current literature regarding vaccination in immunocompromised populations and apply them to sarcoidosis patients. The available literature suggests that vaccines are safe and effective in patients with autoimmune disorders and in those taking immunosuppressive medications. We strongly recommend the administration of COVID-19 vaccines in patients with sarcoidosis. We also present a clinical decision algorithm to provide guidance on vaccination of sarcoidosis patients against COVID-19.

scholarly journals Comparative clinical study of efficacy and safety of adapalene 0.1% gel versus benzoyl peroxide 2.5% gel for the treatment of acne vulgaris

2019 ◽  
Vol 8 (10) ◽  
pp. 2317
Author(s):  
Anuradha Dubey ◽  
Hanmant Amane
Keyword(s):  
Side Effects ◽  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Total Duration ◽  
The Other ◽  
Efficacy And Safety ◽  
Inflammatory Lesions ◽  
Significant Difference ◽  
Comparative Clinical Study ◽  
Topical Treatments

Background: Acne vulgaris is characterised by comedones, papules, pustules and nodules occurring in a sebaceous distribution. Topical treatments, such as adapalene and benzoyl peroxide, are popular in mild to moderate acne vulgaris. This study was aimed to compare the efficacy and safety of adapalene with benzoyl peroxide in the patients of mild to moderate acne vulgaris.Methods: We planned a randomized, open-labelled, prospective study to compare the efficacy and side effects of adapalene and benzoyl peroxide in acne patients. A total of 100 patients with mild to moderate acne vulgaris were included in the study. They were randomly divided into 2 groups with 50 patients in each group. One group was given 0.1% adapalene gel and the other group received 2.5% benzoyl peroxide gel. Efficacy was assessed as reduction in the lesion counts, whereas for safety, the side effects like dryness, burning, irritation, erythema were recorded during the treatment. Total duration of the study was 3 months.Results: The study revealed that adapalene was more effective than benzoyl peroxide in treating non-inflammatory and inflammatory lesions of acne vulgaris, and there was a statistically significant difference found between the groups (p≤0.05) in efficacy. Adapalene was also found to be comparatively safer than benzoyl peroxide because the patients treated with adapalene had lesser side effects than those treated with benzoyl peroxide.Conclusions: Our study concludes a better efficacy and safety of adapalene than benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

scholarly journals DEPRESSION IN ACNE VULGARIS

2018 ◽  
Vol 25 (06) ◽  
pp. 892-895
Author(s):  
Naima Luqman ◽  
Niaz Maqsood ◽  
Wajih-Ur- Rehman
Keyword(s):  
Rating Scale ◽  
Acne Vulgaris ◽  
Severe Depression ◽  
Clinical Severity ◽  
Inflammatory Disorder ◽  
Mild Depression ◽  
Dermatology Department ◽  
Chronic Inflammatory Disorder ◽  
Severity Of Depression ◽  
Hospital Study

INTRODUCTION: Acne vulgaris is a chronic inflammatory disorder of pilo-sebaceous glands,which most commonly affect face and trunk. It is most prevalent in adolescent age group. Ithas been seen that acne can have profound social and psychological effects which are notnecessarily related to its clinical severity. Objectives: To determine the frequency and severity ofdepression among acne patients attending the outpatient dermatology department, of a tertiarycare hospital. Study Design: Descriptive study. Place & Duration of Study: Department ofDermatology, Bahawal Victoria Hospital, Bahawalpur from September, 2013 to November, 2013.Subjects & Methods: Informed written consent was taken from patients for the study, seventypatients of acne, diagnosed by consultant dermatologist were inducted. The severity of acnewas determined by Global Acne Grading System. Both genders were included, the age rangewas from 16 to 40 years. Those patients with concomitant dermatological, psychiatric diseasesand those receiving systemic isotretinoin were excluded. The patients fulfilling inclusioncriteria were assessed for depressive symptoms and Hamilton Depression rating scale wasadministered for severity of depression. Results: 70 patients were included in the study, amongthem 14 (20%) were male and 56 (80%) were females. Most of the acne patients were of the age16-20 years [24 (34.3%)]. Mild depression was seen in 26% patients (18%-were females and8%-males). Severe depression was present in 14% of patients, among which 11% were females& 3% were males. Very severe depression was noted in 18% patients among which 16% werefemale and 2% were males. Conclusions: it can be concluded that Dermatologists should paydue attention to the psychological/ mental state of the patient while clinically evaluating andtreating patients suffering from acne vulgaris

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