STUDIES ON PEPSIN SECRETION BEFORE AND AFTER GASTRIC OPERATIONS IN PATIENTS WITH PEPTIC ULCER

ABSTRACTA study was undertaken to compare mortality from perforated peptic ulcer before and after introduction ofpre-operative, intra-operative and post-operative measures to improve clinical care of patients affected bythis condition. Data was accrued prospectively over 6 months (24 patients) and compared with the previous6 months of historical controls (27 patients). Mortality showed a trend towards improvement. (9/27 c.f. 3/24, p=0.12 n.s., Fisher exact test). Based on these findings and changing ideas in regard to disease transmissionemerging from the recent literature, a framework for limiting mortality from perforated peptic ulcer inNepal is proposed.Key Words: Perforation, peptic ulcer, Nepal, mortality reduction, Helicobacter pylori.

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Variation in the Proportions of Individual Pepsins Secreted by the Cat in Response to Vagal Stimulation and Hypoglycaemia

Clinical Science ◽

10.1042/cs0480297 ◽

1975 ◽

Vol 48 (4) ◽

pp. 297-305

Author(s):

Christine L. Wright ◽

B. Shaw ◽

D. J. Sanders ◽

J. D. Reed

Keyword(s):

Peptic Ulcer ◽

Electrical Stimulation ◽

Small Proportion ◽

Gel Electrophoresis ◽

Vagal Stimulation ◽

Direct Electrical Stimulation ◽

Pepsin Secretion ◽

Agar Gel ◽

Agar Gel Electrophoresis ◽

Stimulation Of

1. Gastric juice was collected at regular intervals during electrical stimulation of the vagus in anaesthetized cats and during insulin hypoglycaemia in both anaesthetized and conscious cats. The total amounts of acid and pepsin secreted were similar in the three groups. 2. Pepsins were examined by agar-gel electrophoresis. Resting juice contained two pepsins, and up to nine pepsins could be detected after stimulation. Three patterns of pepsin secretion were found. 3. The most noticeable feature was the variation in the proportion of total pepsin attributable to the pepsin which migrated most rapidly during electrophoresis (pepsin 1). In response to insulin hypoglycaemia, anaesthetized cats secreted only a small proportion of total pepsin as pepsin 1 and conscious cats secreted a large proportion as pepsin 1. During direct electrical stimulation of the vagus, the proportion of pepsin 1 rose. 4. The possibility of a dependence of pepsin 1 secretion on vagal stimulation is discussed and the relevance of this to peptic ulcer and to vagotomy is considered.

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GASTROSCOPIC AND HISTOLOGIC APPEARANCE OF THE GASTRIC MUCOSA BEFORE AND AFTER VAGOTOMY FOR PEPTIC ULCER

Archives of Internal Medicine ◽

10.1001/archinte.1949.00230020002001 ◽

1949 ◽

Vol 84 (2) ◽

pp. 199 ◽

Cited By ~ 8

Author(s):

JOSEPH B. KIRSNER

Keyword(s):

Peptic Ulcer ◽

Gastric Mucosa ◽

Histologic Appearance ◽

Before And After

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THE GASTRIC ENDOCRINE AND EXOCRINE RESPONSE TO HISTAMINE IN DOGS AND EFFECT OF PASSAGE OF BLOOD THROUGH THE GASTRIC AND HEPATIC VESSELS ON ITS PEPSINOGEN CONTENT

Canadian Journal of Biochemistry and Physiology ◽

10.1139/o56-027 ◽

1956 ◽

Vol 34 (2) ◽

pp. 244-252 ◽

Cited By ~ 3

Author(s):

K. Kowalewski ◽

S. T. Norvell Jr. ◽

Walter C. MacKenzie

Keyword(s):

Body Weight ◽

Experimental Period ◽

Enzyme Concentration ◽

Pepsin Secretion ◽

Gastric Artery ◽

Before And After ◽

Gastric Pepsin ◽

Hepatic Vessels ◽

Endocrine Secretion ◽

Gastric Pepsin Secretion

Subcutaneous histamine in dogs in a dose of 5 mgm. per kgm. of body weight provoked a significant increase in gastric pepsin secretion over a four-hour period. The increased pepsin production was accompanied by increased secretion of free HCl, increased volume of gastric juice, and elevation of plasma pepsinogen in the same experimental period. Plasma pepsinogen levels, before and after histamine, were investigated in a gastric artery, a gastric vein, the portal vein, a hepatic vein, and a cephalic vein. The enzyme concentration was significantly higher in the gastric vein than in the gastric artery and this difference was accentuated following histamine administration. These findings were attributed to endocrine secretion of pepsinogen by the zymogenic cells of the gastric mucosa. There was no evidence that pepsinogen concentration is altered as the blood traverses the liver.

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