scholarly journals Intraparotid Schwannoma

2014 ◽  
Vol 138 (7) ◽  
pp. 982-985 ◽  
Author(s):  
Whitney A. McCarthy ◽  
Bettye L. Cox
Keyword(s):  
Facial Nerve ◽  
Mucoepidermoid Carcinoma ◽  
Preoperative Diagnosis ◽  
Patient Management ◽  
Spatial Relationship ◽  
Needle Aspiration ◽  
Rare Entity ◽  
Warthin Tumor ◽  
Potential Implication ◽  
Critical Consideration

Diagnoses most commonly associated with a unilateral parotid mass include sialadenitis, pleomorphic adenoma, Warthin tumor, and mucoepidermoid carcinoma. However, rare entities, such as intraparotid schwannoma, must be considered in the differential diagnosis. We present a brief literature review that is illustrative of the current difficulty of preoperative diagnosis of intraparotid schwannoma, which is an exceptionally rare entity, with approximately 80 cases described to date. It may mimic common neoplasms and inflammatory salivary gland conditions on fine-needle aspiration and imaging, but is more likely to be associated with the facial nerve. Depending upon the tumor's spatial relationship to the facial nerve and the extent of neurologic dysfunction, the decision may be made to observe the tumor rather than attempt resection. This potential implication for patient management is a critical consideration that highlights the need for timely, appropriate biopsy and diagnosis.

Neurilemmomas of the Facial Nerve Presenting as Parotid Tumors

1984 ◽  
Vol 93 (1) ◽  
pp. 70-72 ◽  
Author(s):  
Viggo H. Balle ◽  
Ole Greisen
Keyword(s):  
Facial Nerve ◽  
Preoperative Diagnosis ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Nerve Grafting ◽  
True Nature ◽  
Fine Needle ◽  
Parotid Tumors ◽  
Correct Preoperative Diagnosis ◽  
Facial Function

Two cases of rare benign facial neurilemmomas are presented. In both cases the only complaint was a parotid mass and both patients had normal facial function. The true nature of the tumors was not discovered before operation. Repeated fine-needle aspiration biopsy did not contribute to a correct preoperative diagnosis. In both instances the facial nerve had to be sacrificed and free autogenous nerve grafting was done.

Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers

2015 ◽  
Vol 59 (5) ◽  
pp. 384-390 ◽  
Author(s):  
Alessandra C. Schmitt ◽  
Cynthia Cohen ◽  
Momin T. Siddiqui
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Salivary Gland Neoplasms ◽  
Benign Lesions ◽  
Warthin Tumor ◽  
Fine Needle ◽  
Negative Results ◽  
Immunohistochemical Markers ◽  
Papillary Cystadenoma

Objectives: We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Material and Methods: 35 FNA CB of oncocytic salivary gland neoplasms, i.e. 13 cases of AciCC, 16 of Warthin tumor (WT), 3 of mucoepidermoid carcinoma (MEC) and 3 of oncocytoma (ONC), and 75 salivary gland resections, i.e. 26 AciCC, 7 WT, 36 MEC, 3 ONC, 2 mammary analog secretory carcinomas (MASC) and 1 papillary cystadenoma were stained for SOX10 and DOG1. Results: None of the benign oncocytic neoplasms were immunoreactive for SOX10 on CB or resection, similar to DOG1. On CB, 61.5 and 77% of AciCC were positive for SOX10 and DOG1, respectively. All surgically resected AciCC cases were positive for SOX10 and DOG1; other malignant oncocytic lesions such as MEC and MASC demonstrated variable SOX10 and DOG1 staining. Conclusion: The use of SOX10 may increase the diagnostic accuracy of oncocytic lesions on FNA. In this context, SOX10 is equivalent to DOG1 in ruling out benign lesions such as WT and ONC; however, negative results for SOX10 as well as DOG1 do not favor a benign diagnosis since MEC is often negative for both markers.

scholarly journals The cytopathologic features of mammary analog secretory carcinoma and its mimics

CytoJournal ◽  
2014 ◽  
Vol 11 ◽  
pp. 24 ◽  
Author(s):  
T. Danielle Samulski ◽  
Virginia A. LiVolsi ◽  
Zubair Baloch
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Definite Diagnosis ◽  
Secretory Carcinoma ◽  
Warthin Tumor ◽  
Fine Needle ◽  
Monomorphic Population ◽  
Mammary Analog Secretory Carcinoma ◽  
Foamy Cytoplasm

Mammary Analogue Secretory Carcinoma (MASC) is a newly recognized neoplasm of the salivary gland, first described in 2010. This tumor harbors a unique translocation, t(12;15)(p13;q25) that results in the fusion of ETV6 with NTRK3 which produces a transformative chimeric tyrosine kinase. To date, few cases of MASC sampled by fine needle aspiration have been reported. Cytologically, MASC can be confused with other oncocytic salivary gland tumors, including Warthin-tumor, acinic cell carcinoma (AciCC) and mucoepidermoid carcinoma. It is characterized by a monomorphic population of lesional cells with round nuclei, prominent nucleoli and abundant, eosinophilic foamy cytoplasm; forming papillary groups with transgressing vessels. Though, based on cytomorphology alone, the definite diagnosis can be challenging, in conjunction with available clinical clues (i.e. male patient, extra-parotid site) MASC should be included in the differential diagnosis of FNA specimens diagnosed as oncocytic salivary gland neoplasms or suspicious for AciCC. Here we present a case of MASC with FNA sampling at our institution.

F.N.A.C. AS DIAGNOSTIC TOOL OF PAROTID TUMORS AND ASSOCIATED PITFALLS IN CORRELATION WITH HISTOPATHOLOGY

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Bhawana Pant ◽  
Sanjay Gaur ◽  
Prabhat Pant
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Tertiary Referral Centre ◽  
Clear Cut ◽  
Parotid Tumors

F.NA.C has been used for ages as a safe and economical tool for fast preoperative diagnosis of parotid tumors. It has certain pitfall which sometimes leads to misdiagnosis and consequently it may have affect on treatment of the tumors. Keeping in view of the diverse classification of parotid tumors’ information from cytology should be combined with radiology as well as clinical diagnosis. Aim: To discuss some cases where there was discrepancy between cytological diagnosis and histopathological result and also suggest measures to improve the efficacy of F.N.A.C. Material and methods: The study includes 50 cases of parotid tumours who presented to the  department of ENT at Government medical college Haldwani which is a tertiary referral centre during 2009 to 2016. Only adult patients were included and inflammatory swelling were excluded from the study. All patients evaluated  Contrast enhanced computerized tomography(CECT) and  Magnetic resonance imaging (MRI) followed by Fine needle aspiration cytology .Preoperative diagnosis was made upon the findings of the above investigations and different types of  parotid surgeries  were done. . Final diagnosis was made on  histopathological  examination. Result :The most common tumour  came out to be pleomorphic adenoma (23 cases-46%) followed by mucoepidermoid carcinoma(12cases-24%). In ten  cases there was no clear cut  association between cytological diagnosis and final histopathological diagnosis. Conclusion: FNAC is highly sensitive and specific technique for diagnosis of many salivary gland swellings. FNAC can be used preoperatively to avoid unnecessary surgery and biopsy. Details of clinical information and radiologic features may help the pathologist to arrive at the appropriate diagnosis and reduce false interpretation. Pitfalls may also occur with improper technique of FNAC which can be overcome by proper caution.

scholarly journals Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

2014 ◽  
Vol 4 (8) ◽  
pp. 654-657 ◽  
Author(s):  
S Koirala ◽  
G Sayami ◽  
AD Pant
Keyword(s):  
Salivary Gland ◽  
Preoperative Diagnosis ◽  
Needle Aspiration ◽  
University Teaching ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Institute Of Medicine ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity ◽  
Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

Deep Lobe Parotid Tumors: A Systematic Review and Meta-analysis

2021 ◽  
pp. 019459982110092
Author(s):  
Margaret H. Aasen ◽  
Michael J. Hutz ◽  
Brian T. Yuhan ◽  
Christopher J. Britt
Keyword(s):  
Facial Nerve ◽  
Imaging Modality ◽  
Meta Analysis ◽  
Needle Aspiration ◽  
Computed Tomography Scan ◽  
Fine Needle ◽  
Deep Lobe ◽  
Parotid Tumors ◽  
Superficial Lobe ◽  
Tomography Scan

Objective We performed a systematic review and meta-analysis of deep lobe parotid tumors to evaluate their unique characteristics. Data Sources PubMed/Medline, Embase, Web of Sciences, and Cochrane Library databases were queried for relevant literature. Review Methods Studies were individually assessed by 2 independent reviewers. Risk of bias was assessed with the Cochrane bias tool, GRADE criteria, and MINORS criteria. Results were reported according to the PRISMA guidelines. Statistical analysis was performed by comparing rates of malignancy between deep and superficial lobe tumors. Results In total, 8 studies including 379 deep lobe parotid tumors met inclusion criteria. Mean age at diagnosis was 44.9 years. Computed tomography scan was the most common imaging modality. Preoperative diagnostic fine-needle aspiration was utilized in 39.4% of patients and demonstrated high sensitivity for malignant disease. The most common approach was subtotal parotidectomy with facial nerve preservation (58.9%). The rate of malignancy was 26.6%, which was significantly higher than that of the superficial lobe tumors in this study (risk ratio, 1.25; 95% CI, 1.01-1.56). The rate of temporary postoperative facial nerve weakness between deep and superficial lobe tumors was 32.5% and 11.7%, respectively. Conclusion Deep lobe parotid tumors had a 26.6% rate of malignancy. On meta-analysis, deep lobe tumors appeared to have higher rates of malignancy than superficial lobe tumors. Surgical excision of deep lobe tumors showed increased rates of temporary facial nerve paresis as compared with superficial lobe tumors. Computed tomography scan was the most common imaging modality. There were limited data regarding the utility of fine-needle aspiration.

The Surgical Biopsy

1978 ◽  
Vol 86 (3) ◽  
pp. ORL-367-ORL-371 ◽  
Author(s):  
Alan M. Nahum ◽  
Paul E. Bernstein ◽  
Sidney Saltzstein
Keyword(s):  
Early Diagnosis ◽  
Patient Management ◽  
Cost Benefit Analysis ◽  
Cost Benefit ◽  
Needle Aspiration ◽  
Metastatic Carcinoma ◽  
Benefit Analysis ◽  
Cervical Lesions ◽  
Surgical Biopsy ◽  
Cervical Lymph Nodes

A cost-benefit analysis of biopsy techniques for deep cervical lesions reveals that the aspiration biopsy is superior in terms of cost, speed, and morbidity but inferior in accuracy. Aspiration is most accurate for the diagnosis of metastatic carcinoma in cervical lymph nodes. An early diagnosis of malignancy by needle aspiration can be of benefit in several stages of patient management.

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