scholarly journals Pulmonary Nodular Lymphoid Hyperplasia

2019 ◽  
Vol 143 (9) ◽  
pp. 1149-1153 ◽  
Author(s):  
Maggie Yell ◽  
Flavia G. Rosado
Keyword(s):  
Lymphoid Tissue ◽  
Lymphoproliferative Disorder ◽  
Marginal Zone ◽  
Correct Diagnosis ◽  
Lymphoid Hyperplasia ◽  
Marginal Zone Lymphoma ◽  
Lung Mass ◽  
Immunoglobulin G4 ◽  
Nodular Lymphoid Hyperplasia ◽  
Histopathologic Diagnosis

Pulmonary nodular lymphoid hyperplasia is an uncommon reactive lymphoproliferative disorder that presents as an asymptomatic lung mass. The histopathologic diagnosis of pulmonary nodular lymphoid hyperplasia may be challenging because of its morphologic overlap with other diseases, such as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and immunoglobulin G4–related sclerosing disease. Despite the similarities, there are distinctive morphologic and phenotypic features that allow for the correct diagnosis in the majority of cases. This review aims to discuss the clinicopathologic features of pulmonary nodular lymphoid hyperplasia and contrast them with its histopathologic mimickers.

scholarly journals The diagnostic challenge of adenocarcinoma in pulmonary nodular lymphoid hyperplasia

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110393
Author(s):  
Anita Savić Vuković ◽  
Melita Kukuljan ◽  
Morana Dinter ◽  
Ksenija Jurinović ◽  
Nives Jonjić
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Plasma Cells ◽  
Radiological Finding ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Diseases ◽  
Diagnostic Challenge ◽  
Immunoglobulin G4 ◽  
Nodular Lymphoid Hyperplasia ◽  
Immunohistochemical Analyses

Pulmonary nodular lymphoid hyperplasia is a rare, nonneoplastic lymphoproliferative disorder mostly manifesting as one or more nodules or localized lung infiltrates. The lesion comprises reactive germinal centers with well-preserved mantle zones and sheets of interfollicular mature plasma cells, lymphocytes, histiocytes, and neutrophils. The radiological finding is not specific, and the diagnosis of pulmonary nodular lymphoid hyperplasia relies generally on pathohistological and immunohistochemical analyses. The most important differential diagnoses are extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and immunoglobulin G4–related sclerosing disease. Nonetheless, we present a case of pulmonary nodular lymphoid hyperplasia in a 69-year-old woman with the diagnostic challenge of cytological atypia in alveolar spaces inside the lymphoid tissue, coexisting with the diagnosis of adenocarcinoma of the lepidic pattern. Therefore, this case highlights the importance of identifying these rare benign and reactive lymphoproliferative diseases given the risk of developing not only lymphoma but also carcinoma.

RARE CASE OF NODULAR LYMPHOID HYPERPLASIA OF LEFT LUNG IN THE PATIENT WITH PREVIOUS PULMONARY TUBERCULOSIS

2018 ◽  
Vol 40 (4) ◽  
pp. 332-335
Author(s):  
P V Kuzyk ◽  
M A Savchyna ◽  
S G Gychka
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lymphoproliferative Disorder ◽  
Clinical Laboratory ◽  
Left Lung ◽  
Lymphoid Hyperplasia ◽  
Morphological Examination ◽  
Nodular Lymphoid Hyperplasia ◽  
Lymph Nodes Dissection ◽  
The Right ◽  
Immunohistochemical Studies

Aim: To describe the case of rare benign lymphoproliferative disorder — pulmonary nodular lymphoid hyperplasia in the patient with previous pulmonary tuberculosis. Materials and Methods: In the case of pulmonary nodular lymphoid hyperplasia clinical, laboratory, instrumental and morphological examination was performed. Results: 44-year-old woman in 7 years after successfully treated infiltrative drug-susceptible tuberculosis of the right lung, was hospitalized with a suspected tumor of the left lung root. The patient underwent left-sided pneumonectomy with lymph nodes dissection. The results of histopathological and immunohistochemical studies evidenced on nodular lymphoid hyperplasia of the left lung. Conclusion: Pulmonary nodular lymphoid hyperplasia is a rare lymphoproliferative disorder of the lung with favorable prognosis. For the purpose of differential diagnosis, it is necessary to apply immunohistochemistry.

scholarly journals Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells

2021 ◽  
Vol 22 (8) ◽  
pp. 4083
Author(s):  
Asami Nishikori ◽  
Yoshito Nishimura ◽  
Rei Shibata ◽  
Koh-ichi Ohshima ◽  
Yuka Gion ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Somatic Hypermutation ◽  
Cytidine Deaminase ◽  
Marginal Zone Lymphoma ◽  
Immunoglobulin G4 ◽  
Intensity Index ◽  
Activation Induced Cytidine Deaminase ◽  
Systemic Disorder ◽  
Lymphoplasmacytic Infiltration ◽  
Ophthalmic Disease

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. We examined AID expression in IgG4-related ophthalmic disease (IgG4-ROD; n = 16), marginal zone lymphoma with IgG4-positive cells (IgG4+ MZL; n = 11), and marginal zone lymphoma without IgG4-positive cells (IgG4- MZL; n = 12) of ocular adnexa using immunohistochemical staining. Immunohistochemistry revealed significantly higher AID-intensity index in IgG4-ROD and IgG4+ MZL than IgG4- MZL (p < 0.001 and = 0.001, respectively). The present results suggest that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation, and AID may be a driver of oncogenesis in IgG4-ROD to IgG4+ MZL.

Clinical, histological and molecular follow-up of 60 patients with gastric marginal zone lymphoma of mucosa-associated lymphoid tissue

2005 ◽  
Vol 446 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Antoine de Mascarel ◽  
Agnès Ruskone-Fourmestraux ◽  
Anne Lavergne-Slove ◽  
Francis Megraud ◽  
Pierre Dubus ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type arising in the pleura with pleural fibrous plaques in a lathe worker

2012 ◽  
Vol 16 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Shin-ichi Nakatsuka ◽  
Teruaki Nagano ◽  
Hayato Kimura ◽  
Shoji Hanada ◽  
Hidetoshi Inoue ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Tissue Type ◽  
Extranodal Marginal Zone Lymphoma

scholarly journals Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

2020 ◽  
Vol 54 (4) ◽  
pp. 340-345
Author(s):  
Soyeon Choi ◽  
Ji Hye Kim ◽  
Kyungbin Kim ◽  
Misung Kim ◽  
Hye Jeong Choi ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Extranodal Marginal Zone Lymphoma
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