scholarly journals Previsão da taxa de incidência dos casos de AIDS no município de Santa Maria – RS

2020 ◽  
Vol 42 ◽  
pp. e49
Author(s):  
Camila Malu da Rosa ◽  
Fernando De Jesus Moreira Junior ◽  
Cleber Bisognin

The spread of AIDS was a striking social fact in the late twentieth century, mainly due to the lack of knowledge of sexually active people and drug users, spreading rapidly across five continents. Initially, it was associated with the group of male homosexuals. Over the years, other population segments became infected with the Human Immunodeficiency Virus (HIV). Thus, this article aims to compare forecasting methodologies to predict the incidence rate of AIDS per 100,000 inhabitants in Santa Maria between 2017 and 2022. For this purpose, two forecasting models were adjusted for each series (polynomial trend model plus an ARIMA model (p, d, q), and an exponential smoothing model). As the series show structural breakdowns due to various historical events in Brazil and around the world, prediction combinations methodologies were used through robust regressions, using the Weighted Least Squares, MM and Quantile Regression methods. We verified through the accuracy measures that, for men, the best forecasting methodologies were Model 1 and the regression forecast combinations, using the MM and RQ methods. For women, the best methodologies were Model 1 and regression prediction combinations by the RQ method.

1990 ◽  
Vol 80 (1) ◽  
pp. 3-8
Author(s):  
SL Becker

Human immunodeficiency virus (HIV) is a retrovirus that can be transmitted through sexual activity, blood products, and perinatal exposure. The virus is composed of core, transmembrane, and envelope proteins. Cells of the immune system are the primary target of HIV, and destruction of the immune response is characteristic of end-stage disease. Although male homosexuals continue to represent the largest population of persons with acquired immunodeficiency syndrome (AIDS), transmission among intravenous drug users accounts for the rapidly growing incidence of pediatric and heterosexual AIDS patients. Control of the epidemic among intravenous drug users is the major challenge in the US today.


2016 ◽  
Vol 29 (10) ◽  
pp. 639 ◽  
Author(s):  
Vilma Grilo ◽  
Aida Pereira

Introduction: Pneumocystis jirovecii pneumonia remains one of the most common opportunistic illnesses in patients infected with the human immunodeficiency virus. It is currently the most reported AIDS-defining infection in Portugal. The aims of this study were to analyze the features of a human immunodeficiency virus /Pneumocystis jirovecii pneumonia coinfected population, to compare it with the current literature, and to evaluate comparatively subpopulations of patients based on the previous knowledge of the human immunodeficiency virus infection, Pneumocystis jirovecii pneumonia diagnostic method and discharge results.Material and Methods: A retrospective, observational, non-controlled study was conducted. The 107 patients admitted to the Department of Infectious Diseases at Santa Maria Hospital, in Lisbon, between the 1st of January 2002 and the 31st of December 2013, that presented the simultaneous diagnosis of human immunodeficiency virus infection and Pneumocystis jirovecii pneumonia were included. We studied epidemiologic and clinical data collected from the patient files, including immunity status, human immunodeficiency virus viral load and treatment options. The variables were analyzed using the Chi-Squared and Mann-Whitney tests.Results: Data from this population evidenced male predominance (81.3%), patient age between 20 - 39 years old in 59.2% and heterossexual human immunodeficiency virus transmission in 48.6%; 24.3% were immigrants. Human immunodeficiency virus infection was previously known in 62.6% patients, but 76.2% were not engaged in medical care. A TCD4+ cell count ≤ 200 cells/mm3, high viralload and oropharyngeal candidiasis (72%) were prevalent risk factors associated with the Pneumocystis jirovecii pneumonia infection; hypoxaemia (78.5%) and LDH (82.2%), which are markers of Pneumocystis jirovecii pneumonia severity, did not translate into a worseprognosis. Pneumocystis jirovecii was only identified in 55.1% patients, pointing out the hardship involved in achieving a definite diagnosis. The inicial drug of choice was TMP-SMX (91.6%), and corticosteroid adjuvant therapy was added in 75.7%. The in-hospital mortality was 13.1%.Discussion: The comparative analysis between groups of patients showed that injection drug users knew more frequently their human immunodeficiency virus seropositivity before the current hospitalization, which could be explained by the presence of specific programs aiming the early human immunodeficiency virus diagnosis in this population. However, there is lack of adhesion to the treatment andfollow up consultations, putting them at a higher risk of Pneumocystis jirovecii pneumonia infection and other AIDS related diseases. Besides showing the classic Pneumocystis jirovecii pneumonia presentation, healthcare seeking was delayed, especially amongst patients with newly diagnosed human immunodeficiency virus infection. Moreover, the Pneumocystis jirovecii pneumonia diagnosis was difficult to obtain, mainly because of the current limitations of Pneumocystis jirovecii pneumonia diagnostic techniques, the simultaneous presence of other respiratory diseases, and the need of a high degree of clinical suspicion.Conclusion: This population of human immunodeficiency virus and Pneumocystis jirovecii pneumonia coinfected patients shows similarities with the data from previous studies, particularly considering Portuguese epidemiological data. The main differences found were the Pneumocystis jirovecii pneumonia diagnostic frequence in injection drug users, the importance of previous/recurrent episodes of Pneumocystis jirovecii pneumonia as a risk factor and the frequency of concurrent pulmonary diseases. The deceased patients showed less imagiologic features suggestive of Pneumocystis jirovecii pneumonia, and advanced age was found to be an indicative of worst prognosis.


2003 ◽  
Vol 37 (s5) ◽  
pp. S404-S409 ◽  
Author(s):  
Roberto Muga ◽  
Arantza Sanvisens ◽  
José Manuel Egea ◽  
Jordi Tor ◽  
Celestino Rey‐Joly

1989 ◽  
Vol 29 (3) ◽  
pp. 181-185 ◽  
Author(s):  
David M. Novick ◽  
Harold L. Trigg ◽  
Don C. Des Jarlais ◽  
Samuel R. Friedman ◽  
David Vlahov ◽  
...  

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