Peripheral ulcerative keratitis as presenting manifestation of systemic microscopic polyangiitis: a case report

Abstract Introduction: Peripheral ulcerative keratitis (PUK) is an aggressive, potentially sight-threatening cause for peripheral corneal thinningCase report: A 43-year-old woman presented with bilateral tearing and ocular pain persisting for 7 months. Visual acuity was 6/6 in both eyes. On biomicroscopic examination, presence of crescent shaped corneal ulcer with perilesional haziness. A tear film study demonstrated decreased Schirmer test results (5mm in both eyes) and tear film break-up time (5 sec in both eyes). The interrogation and the patient revealed he had recurrent skin lesions in both legs with chronic itching, and recurrent oral and genital ulcers healing spontaneously. The diagnosis of behcet disease was proposed.Conclusion: Collaborative management of ophthalmic patients having systemic illness along with internists improves overall outcomes and prevents morbidity in such patients.

Download Full-text

Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment

Journal of Ophthalmology ◽

10.1155/2017/7298026 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 10

Author(s):

Yan Cao ◽

Wensong Zhang ◽

Jie Wu ◽

Hong Zhang ◽

Hongyan Zhou

Keyword(s):

Lupus Erythematosus ◽

Microscopic Polyangiitis ◽

Corneal Stroma ◽

Relapsing Polychondritis ◽

Wegener Granulomatosis ◽

Inflammatory Damage ◽

Peripheral Ulcerative Keratitis ◽

Strauss Syndrome ◽

Ulcerative Keratitis ◽

Churg Strauss

Peripheral ulcerative keratitis (PUK) is type of crescent-shaped inflammatory damage that occurs in the limbal region of the cornea. PUK is always combined with an epithelial defect and the destruction of the peripheral corneal stroma. PUK may have a connection to systemic conditions, such as long-standing rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Wegener granulomatosis (WG), relapsing polychondritis, classic polyarteritis nodosa and its variants, microscopic polyangiitis, and Churg-Strauss syndrome. However, the most common connection is with RA, which is also the focus of this review. The pathogenesis of PUK is still unclear. It is thought that circulating immune complexes and cytokines exert an important influence on the progression of this syndrome. Treatment is applied to inhibit certain aspects of PUK pathogenesis.

Download Full-text

Peripheral ulcerative keratitis as the first manifestation of Rheumatoid Arthritis – case report

10.47660/cbr.2021.1898 ◽

2021 ◽

Author(s):

Danielly Dantas Pimentel ◽

TAISA MORETE DA SILVA ◽

IANE TAMARA DONDE ◽

PATRICIA MILANI DE MORAES ◽

CARLOS AUGUSTO RODRIGUES PADILHA ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Case Report ◽

Rheumatoid Arthritis Case ◽

Peripheral Ulcerative Keratitis ◽

Ulcerative Keratitis

Download Full-text

Systemic Paraquat Intoxication Presenting with Peripheral Ulcerative Keratitis: A Case Report and Literature Review

Ocular Immunology and Inflammation ◽

10.1080/09273948.2019.1640882 ◽

2019 ◽

Vol 28 (6) ◽

pp. 871-875

Author(s):

Jung Lo ◽

Linda Yi-Chieh Poon

Keyword(s):

Case Report ◽

Literature Review ◽

Peripheral Ulcerative Keratitis ◽

Ulcerative Keratitis

Download Full-text

Perforating Peripheral Ulcerative Keratitis in Syphilis

Case Reports in Ophthalmology ◽

10.1159/000501996 ◽

2019 ◽

Vol 10 (2) ◽

pp. 267-273

Author(s):

Pimpiroon Ploysangam ◽

Ruth Marie Mattern

Keyword(s):

Case Report ◽

Sexual Partners ◽

Corneal Perforation ◽

Syphilis Infection ◽

Case Presentation ◽

Multiple Sexual Partners ◽

Peripheral Ulcerative Keratitis ◽

Ulcerative Keratitis

Purpose: To present a case of peripheral ulcerative keratitis with perforation in the setting of syphilis. Method: A single observational case report in urban USA. Case Presentation: A patient with multiple sexual partners presented with bilateral peripheral ulcerative keratitis, unilateral corneal perforation, and a pustular rash. Workup was positive for syphilis as well as HSV, HIV, and multiple autoantibody tests. Findings improved after treatment for syphilis. Conclusion: Bilateral peripheral ulcerative keratitis in syphilis has been reported in one prior case. However, corneal perforation in the setting of syphilis infection has not, to our knowledge, been reported previously.

Download Full-text