Hacia un modelo Transdiagnóstico integrador de la Psicopatología externalizante [Towards an Integrative Transdiagnostic Model of the Externalizing Psychopathology]

Importance: Large consortia of genome wide association studies have yielded more accurate polygenic risk scores (PRS) that aggregate the small effects of many genetic variants to characterize the genetic architecture of disorders and provide a personalized measure of genetic risk. Objective: We examined whether a PRS for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits. We examined these associations at multiple time points in adolescence using more refined phenotypes defined by stable characteristics across time and at young ages, which reduced potential confounds associated with cumulative exposure to substances and reverse causality. Methods: Random intercept panel models were fit to symptoms of conduct disorder, oppositional defiant disorder, major depressive disorder (MDD), and teacher ratings of externalizing and internalizing problems and personality traits at ages 11, 14, and 17 years-old in the Minnesota Twin Family Study (N = 3225). Results: The smoking PRS had strong associations with the random intercept factors for all the externalizing measures (mean standardized ꞵ = .27), agreeableness (ꞵ=-.22, 95% CI: -.28, -.16), and conscientiousness (ꞵ=-.19, 95% CI: -.24, -.13), but was not significantly associated with the internalizing measures (mean ꞵ = .06) or extraversion (ꞵ=.01, 95% CI: -.05, .07). After controlling for smoking at age 17, the associations with the externalizing measures (mean ꞵ = .13) and personality traits related to behavioral control (mean ꞵ = -.10) remained statistically significant. Conclusions and Relevance: The smoking PRS measures genetic influences that contribute to a spectrum of phenotypes related to behavioral disinhibition including externalizing psychopathology and normal-range personality traits related to behavioral control, but not internalizing psychopathology. Continuing to identify the correlates and delineate the mechanisms of the genetic influences associated with disinhibition could have substantial impact in mitigating a variety of public health problems (e.g., mental health, academic achievement, criminality).

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An Ecological Momentary Assessment Examination of the Transdiagnostic Model of Food and Alcohol Disturbance

Journal of Psychopathology and Behavioral Assessment ◽

10.1007/s10862-021-09908-w ◽

2021 ◽

Author(s):

Tyler B. Mason ◽

Ross D. Crosby ◽

Robert Dvorak ◽

Scott G. Engel ◽

Stephen A. Wonderlich ◽

...

Keyword(s):

Ecological Momentary Assessment ◽

Ecological Momentary ◽

Momentary Assessment ◽

Transdiagnostic Model

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Polygenic Score for Smoking Is Associated With Externalizing Psychopathology and Disinhibited Personality Traits but Not Internalizing Psychopathology in Adolescence

Clinical Psychological Science ◽

10.1177/21677026211002117 ◽

2021 ◽

pp. 216770262110021

Author(s):

Brian M. Hicks ◽

D. Angus Clark ◽

Joseph D. Deak ◽

Mengzhen Liu ◽

C. Emily Durbin ◽

...

Keyword(s):

Personality Traits ◽

Behavioral Control ◽

Behavioral Disinhibition ◽

Multiple Time ◽

Normal Range ◽

Polygenic Score ◽

Externalizing Psychopathology ◽

Internalizing Psychopathology ◽

Multiple Time Points ◽

Related Personality

We examined whether a polygenic score (PGS) for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits at multiple time points in adolescence (ages 11, 14, and 17 years; N = 3,225). The smoking PGS had strong associations with the stable variance across time for all the externalizing measures (mean standardized β = 0.27), agreeableness (β = −0.22, 95% confidence interval [CI] = [−0.28, −0.16]), and conscientiousness (β = −0.19, 95% CI = [−0.24, −0.13]) but was not significantly associated with internalizing measures (mean β = 0.06) or extraversion (β = 0.01, 95% CI = [−0.05, 0.07]). After controlling for smoking at age 17 years, the associations with externalizing, low agreeableness, and low conscientiousness remained statistically significant. The smoking PGS measures genetic influences that contribute to a spectrum of phenotypes related to behavioral disinhibition, including externalizing psychopathology and normal-range personality traits related to behavioral control but not internalizing psychopathology.

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Developmental Variation in the Associations of Attention Bias to Emotion with Internalizing and Externalizing Psychopathology

Research on Child and Adolescent Psychopathology ◽

10.1007/s10802-020-00751-3 ◽

2021 ◽

Author(s):

Jessica L. Jenness ◽

Hilary K. Lambert ◽

Debbie Bitrán ◽

Jennifer B. Blossom ◽

Erik C. Nook ◽

...

Keyword(s):

Attention Bias ◽

Externalizing Psychopathology ◽

Developmental Variation ◽

Internalizing And Externalizing

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Distinguishing Levels of Suicide Risk in Depressed Male Veterans: The Role of Internalizing and Externalizing Psychopathology as Measured by the MMPI-2-RF

Assessment ◽

10.1177/1073191117743787 ◽

2017 ◽

Vol 26 (1) ◽

pp. 85-98 ◽

Cited By ~ 3

Author(s):

Stephanie N. Miller ◽

Melanie L. Bozzay ◽

Yossef S. Ben-Porath ◽

Paul A. Arbisi

Keyword(s):

Suicide Risk ◽

Minnesota Multiphasic Personality Inventory ◽

Therapeutic Interventions ◽

Externalizing Psychopathology ◽

Hierarchical Logistic Regression ◽

Male Veterans ◽

Scale Scores ◽

Suicidal Death ◽

Psychiatrically Hospitalized

Suicide occurs at high rates among veterans, underscoring a need for improved identification of veterans at risk of engaging in suicidal behavior. Considering dimensions of psychopathology in the context of an ideation-to-action framework, the present study examined the utility of the Minnesota Multiphasic Personality Inventory–2–Restructured Form in distinguishing depressed, psychiatrically hospitalized male veterans ( N = 430) at varying levels of suicide risk. Analysis of variance and hierarchical logistic regression analyses indicated that internalizing scales differentiated depressed ideators ( n = 147) and depressed controls ( n = 143); and in line with expectations, both broad and narrowly focused externalizing scales provided incremental validity in distinguishing depressed attempters ( n = 140) from depressed ideators. Interactions between Suicidal/Death Ideation and externalizing scale scores were found to differentiate only depressed ideators from depressed controls. Clinical implications in the areas of suicide risk assessment and therapeutic interventions with suicidal veterans are discussed.

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Insomnia and risk for suicidal behavior: A test of a mechanistic transdiagnostic model in veterans

Journal of Affective Disorders ◽

10.1016/j.jad.2018.11.044 ◽

2019 ◽

Vol 245 ◽

pp. 412-418 ◽

Cited By ~ 7

Author(s):

Peter C. Britton ◽

Jessica M. McKinney ◽

Todd M. Bishop ◽

Wilfred R. Pigeon ◽

Jameson K. Hirsch

Keyword(s):

Suicidal Behavior ◽

Transdiagnostic Model

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Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study

Development and Psychopathology ◽

10.1017/s0954579415001108 ◽

2016 ◽

Vol 28 (2) ◽

pp. 527-536 ◽

Cited By ~ 23

Author(s):

Kristin S. Lancefield ◽

Alessandra Raudino ◽

Johnny M. Downs ◽

Kristin R. Laurens

Keyword(s):

Middle Childhood ◽

Psychotic Disorders ◽

Community Sample ◽

Psychiatric Morbidity ◽

Primary Caregivers ◽

Sampling Bias ◽

Population Based ◽

Prospective Data ◽

Externalizing Psychopathology ◽

Internalizing And Externalizing

AbstractAdolescent internalizing and externalizing psychopathology is strongly associated with adult psychiatric morbidity, including psychotic disorders. This study examined whether internalizing or externalizing trajectories (continuity/discontinuity of symptoms) from middle childhood were associated with adolescent psychotic-like experiences (PLEs). Prospective data were collected from a community sample of 553 children (mean age = 10.4 years; 50% male) and their primary caregivers. Participants completed questionnaire reports of internalizing and externalizing psychopathology and PLEs at baseline, and again approximately 2 years later. Logistic regression was used to examine the association of adolescent PLEs with four trajectories of internalizing and externalizing psychopathology (persistent, incident, remitting, and none), controlling for a range of potential confounders and sampling bias. Significant associations were identified between adolescent PLEs and the incident internalizing (adjusted odds ratio [adj. OR] = 2.96; 95% confidence interval [CI] = 1.60–5.49) and externalizing psychopathology (adj. OR = 2.14; 95% CI = 1.11–4.14) trajectories, as well as the persistent internalizing (adj. OR = 1.90; 95% CI = 1.13–3.18) and externalizing (adj. OR = 1.81, 95% CI = 1.02–3.19) trajectories. Children with remitting psychopathology trajectories were no more likely to present later PLEs than those who never experienced psychopathology. While for many individuals symptoms and illness remit during development without intervention, this study provides important insights regarding potential targets and timing for delivery of early intervention and prevention programs.

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