scholarly journals Preclinical Efficacy and Clinical Feasibility of a Novel Aerosol-Exposure Protection Mask for Esophagogastroduodenoscopy

2021 ◽  
Author(s):  
Mai Ego Makiguchi ◽  
Seiichiro Abe ◽  
Yutaka Okagawa ◽  
Satoru Nonaka ◽  
Haruhisa Suzuki ◽  
...  
Keyword(s):  
Aerosol Exposure ◽  
Preclinical Efficacy

ID: 3523009 PRECLINICAL EFFICACY AND CLINICAL FEASIBILITY OF A NOVEL AEROSOL-EXPOSURE PROTECTION MASK FOR ESOPHAGOGASTRODUODENOSCOPY(EGD)

2021 ◽  
Vol 93 (6) ◽  
pp. AB20
Author(s):  
Mai Ego ◽  
Seiichiro Abe ◽  
Yutaka Okagawa ◽  
Satoru Nonaka ◽  
Haruhisa Suzuki ◽  
...  
Keyword(s):  
Aerosol Exposure ◽  
Preclinical Efficacy

New models of breast and lung cancer bone metastases for preclinical efficacy testing

2016 ◽  
Author(s):  
Mari I. Suominen ◽  
Urs B. Hagemann ◽  
Yvonne Konkol ◽  
Jenni Bernoulli ◽  
Katja M. Fagerlund ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Metastases ◽  
New Models ◽  
Preclinical Efficacy

Preclinical efficacy of PF-04942847, a novel HSP90 inhibitor, in osteosarcoma

2014 ◽  
Author(s):  
Francois Lamoureux ◽  
Marc Baud'Huin ◽  
Benjamin Ory ◽  
Dominique Heymann ◽  
Francoise Redini
Keyword(s):  
Hsp90 Inhibitor ◽  
Preclinical Efficacy

scholarly journals A survey of aerosol exposure systems relative to the analysis of cytotoxicity: A Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) perspective

2021 ◽  
Vol 5 ◽  
pp. 239784732110222
Author(s):  
David Thorne ◽  
Roman Wieczorek ◽  
Toshiro Fukushima ◽  
Han-Jae Shin ◽  
Robert Leverette ◽  
...  
Keyword(s):  
Scientific Research ◽  
Toxicity Testing ◽  
User Preferences ◽  
In Vitro Toxicity ◽  
Aerosol Generation ◽  
Aerosol Exposure ◽  
Comprehensive Survey ◽  
Survey Results ◽  
System Data

During a Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) meeting, the in vitro toxicity testing Sub-Group (IVT SG) met to discuss the evolving field of aerosol exposure research. Given the diversity of exposure parameters and biological endpoints being used, it was considered a high priority to investigate and contextualise the responses obtained. This is particularly driven by the inability to compare between studies on different exposure systems due to user preferences and protocol differences. Twelve global tobacco and contract research companies met to discuss this topic and formulate an aligned approach on how this diverging field of research could be appropriately compared. Something that is becoming increasingly important, especially in the light of more focused regulatory scrutiny. A detailed and comprehensive survey was conducted on over 40 parameters ranging from aerosol generation, dilution and data analysis across eight geographically independent laboratories. The survey results emphasise the diversity of in vitro exposure parameters and methodologies employed across the IVT SG and highlighted pockets of harmonisation. For example, many of the biological protocol parameters are consistent across the Sub-Group. However, variables such as cell type and exposure time remain largely inconsistent. The next steps for this work will be to map parameters and system data against biological findings and investigate whether the observed inconsistencies translate into increased biological variability. The results from the survey provide improved awareness of parameters and nuances, that may be of substantial benefit to scientists in intersecting fields and in the development of harmonised approaches.

scholarly journals Acute electronic vapour product whole aerosol exposure of 3D human bronchial tissue results in minimal cellular and transcriptomic responses when compared to cigarette smoke

2021 ◽  
Vol 5 ◽  
pp. 239784732098849
Author(s):  
Gary Phillips ◽  
Lukasz Czekala ◽  
Holger P Behrsing ◽  
Khalid Amin ◽  
Jessica Budde ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Recovery Time ◽  
Beat Frequency ◽  
Transcriptomic Response ◽  
Potential Harm ◽  
Aerosol Exposure ◽  
Cell Culture Systems ◽  
Computational Sciences ◽  
Potential Risks ◽  
Reduced Toxicity

The use of electronic vapour products (EVPs) continues to increase worldwide and with advances in cell culture systems, molecular biology and the computational sciences there is also accumulating evidence of their potential reduced toxicity and reduced potential harm when compared to cigarette smoke. To further understand the potential risks and health effects associated with exposure to EVP aerosols we have assessed the cellular and transcriptomic response from a commercially available lung tissue culture system (MucilAirTM) following a single sub-cytotoxic exposure to cigarette smoke and the equivalent nicotine delivered dose of EVP aerosol. The transcriptomic, cellular (cilia beat frequency (CBF) and percent active area (%AA), trans epithelial electrical resistance (TEER), histology) and cytokine release were assessed at 4- and 48- hours following recovery from air, EVP aerosol (8.4% V/V: mybluTM blueberry flavour, 2.4% nicotine) and 3R4F smoke (3.5% V/V: exposure). No pathological changes were observed at either recovery time point from any exposure. Air and EVP aerosol exposure had no effect on CBF, %AA nor TEER at 48 hours. Exposure to cigarette smoke resulted in a decrease in TEER, an increase in CBF and the release of proinflammatory cytokines at both recovery time points. Although the number of significantly expressed genes was minimal following exposure to EVP aerosol, exposure to 3R4F smoke resulted in a significant upregulation of several disease relevant pathways. These data provide evidence that following an acute exposure to EVP aerosol there is significantly less damage to lung cells in culture than the equivalent, nicotine based, dose of cigarette smoke.

scholarly journals Preclinical efficacy spectrum and pharmacokinetics of ixabepilone

2008 ◽  
Vol 63 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Francis Y. F. Lee ◽  
Richard Smykla ◽  
Kathy Johnston ◽  
Krista Menard ◽  
Kelly McGlinchey ◽  
...  
Keyword(s):  
Preclinical Efficacy

IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer

2021 ◽  
Vol 522 ◽  
pp. 32-43
Author(s):  
Heng Liang ◽  
Tianqi Li ◽  
Xin Fang ◽  
Zikang Xing ◽  
Shengnan Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dual Inhibitor ◽  
Preclinical Efficacy

scholarly journals Preclinical efficacy of prexasertib in acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Jason Ostergaard ◽  
Leslie M. Jonart ◽  
Maryam Ebadi ◽  
Stacia L. Koppenhafer ◽  
David J. Gordon ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Preclinical Efficacy

Job Tasks as Determinants of Thoracic Aerosol Exposure in the Cement Production Industry

2017 ◽  
Vol 62 (1) ◽  
pp. 88-100 ◽  
Author(s):  
Hilde Notø ◽  
Karl-Christian Nordby ◽  
Øivind Skare ◽  
Wijnand Eduard
Keyword(s):  
Cement Production ◽  
Job Tasks ◽  
Aerosol Exposure ◽  
Production Industry

Bioaerosol Exposure Method for Package Integrity Testing†

1996 ◽  
Vol 59 (7) ◽  
pp. 768-771 ◽  
Author(s):  
SCOTT W. KELLER ◽  
JOSEPH E. MARCY ◽  
BARBARA A. BLAKISTONE ◽  
GEORGE H. LACY ◽  
CAMERON R. HACKNEY ◽  
...  
Keyword(s):  
Particle Size ◽  
Test Organism ◽  
Hole Diameter ◽  
Pseudomonas Fragi ◽  
Integrity Testing ◽  
Aerosol Exposure ◽  
Exposure Method ◽  
Test Organisms ◽  
Organism Growth ◽  
Bioaerosol Exposure

Test organism motility, concentration, aerosol exposure time, hole diameter and length were evaluated to determine their influence on microbial ingress into a flexible plastic pouch. Microtubes with 10- and 20-μm hole diameters and of 5- and 10-mm lengths were used as defects in 128 flexible pouches. A bioaerosol with a 2.68-μm mean particle size comprised of 102 or 106 CFU/ml source concentrations of motile or nonmotile Pseudomonas fragi TM 849 was introduced into a 119,911-cm3 chamber for exposures of 15 or 30 minutes. Six pouches showed test organism growth after a 72-h incubation period. Microbial ingress was significant (P < .05) for motile test organisms with source concentrations of 106 CFU/ml.

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