Alzheimer disease and a potential role of herbs-A review

2018 ◽  
Vol 11 (6) ◽  
pp. 2695
Author(s):  
Malarkodi Velraj ◽  
N. Lavaniya
Keyword(s):  
Alzheimer Disease ◽  
Potential Role

scholarly journals Potential Role of Aminoprocalcitonin in the Pathogenesis of Alzheimer Disease

2016 ◽  
Vol 186 (10) ◽  
pp. 2723-2735 ◽  
Author(s):  
Eva Tavares ◽  
Desiree Antequera ◽  
Irene López-González ◽  
Isidro Ferrer ◽  
Francisco J. Miñano ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Potential Role

scholarly journals Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease

2016 ◽  
Vol 18 (2) ◽  
pp. 174-195 ◽  
Author(s):  
Laura Xicota ◽  
Jose Rodriguez-Morato ◽  
Mara Dierssen ◽  
Rafael de la Torre
Keyword(s):  
Alzheimer Disease ◽  
Secondary Prevention ◽  
Potential Role

Alzheimer Disease: Perspectives from Epidemiology and Genetics

2018 ◽  
Vol 46 (3) ◽  
pp. 694-698 ◽  
Author(s):  
Jonathan L. Haines
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Potential Role ◽  
Genetic Influences ◽  
Burden Of Care ◽  
Genetic Etiology ◽  
Societal Problem ◽  
History Of ◽  
The Brain

Alzheimer disease (AD) is a huge and growing societal problem with upwards of 35% of the population over the age of 80 developing the disease. AD results in a loss of memory, the ability to make reasoned and sound decisions, and ultimately the inability to take care of oneself. AD has an impact not only on the sufferer, but their caretakers and loved ones, who must take on a costly and time-consuming burden of care. AD is found in virtually all racial and ethnic groups. Genetic influences on AD are substantial, and there has been a 30 year history of both success and failure. Mutations for rare early onset forms of the disease have been identified, but this information has not yet led to an effective treatment. Multiple common genetic variations have also been identified, and have led to new insights into the potential role of microglia cells in addition to neuronal cells in the brain. Despite intensive efforts, a significant portion of the genetic etiology of AD remains unknown and must be identified.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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