Terminalia chebula Retz improve memory and learning in Alzheimer's Model: (Experimental Study in Rat)

Objective: To study the spasmogenic and spasmolytic properties of Terminalia chebula. Diagnostic parameter of smoothmuscle activity was used for the determination of characteristic spasmogenic and spasmolytic activity of T. chebula. Design:Experimental study. Setting: This experimental study was carried out at the Department of Pharmacology, Faculty of Pharmacy, KarachiUniversity. Period: From 2005 to 2006. Material & method: This experimental study was conducted on isolated smooth muscle ofrabbit's intestine. Segment of small intestine (jejunum and ileum) was mounted in Tyroid's solution filled organ bath with maintainedo temperature at 37 C to record dose response activity. Results: It is observed that at the dose of 1 mg/ml there is a slight decrease in theresponse (0.88 cm 0.035 cm) as compare to control (1.15cm 0.040 cm). At 10 mg/ml there is a relaxing response of smooth muscleactivity (0.85cm 0.08cm) from control (1.08cm 0.125cm). While the relaxation is prominent at the doses of 20 mg/ml (0.9cm 0.5cm)and 25 mg/ml (0.55cm 0.035cm) from control (1.4cm 0.155cm) and (1.3cm 0.07cm) respectively with (p value 0.05). The effect of-2 ethyl acetate fraction shows initially relaxation and this effect disappeared after the administration of acetylcholine 1x10 M, but fullresponse of acetylcholine is not produced due to occupancy of muscarinic receptor by the extract. Conclusions: The effect of T. chebulashowed a spontaneous decrease in the movement of smooth muscles of rabbit's intestine as compared to control experiments.

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Review for "Detection of memory‐ and learning‐ related brain connectivity changes following trace eyeblink‐conditioning using resting‐state functional magnetic resonance imaging in the awake rabbit"

10.1002/cne.25042/v2/review2 ◽

2020 ◽

Author(s):

Wen-Ju Pan

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Resting State ◽

Brain Connectivity ◽

Eyeblink Conditioning ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Memory And Learning ◽

Trace Eyeblink Conditioning

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Decision letter for "Detection of memory‐ and learning‐ related brain connectivity changes following trace eyeblink‐conditioning using resting‐state functional magnetic resonance imaging in the awake rabbit"

10.1002/cne.25042/v2/decision1 ◽

2020 ◽

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Resting State ◽

Brain Connectivity ◽

Eyeblink Conditioning ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Memory And Learning ◽

Trace Eyeblink Conditioning

Download Full-text

Review for "Detection of memory‐ and learning‐ related brain connectivity changes following trace eyeblink‐conditioning using resting‐state functional magnetic resonance imaging in the awake rabbit"

10.1002/cne.25042/v1/review1 ◽

2020 ◽

Author(s):

Wen-Ju Pan

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Resting State ◽

Brain Connectivity ◽

Eyeblink Conditioning ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Memory And Learning ◽

Trace Eyeblink Conditioning

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Experimental study on the restoration from a tilt-azimuth series for improvement in resolution

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010013955x ◽

1995 ◽

Vol 53 ◽

pp. 636-637

Author(s):

Norio Baba ◽

Norihiko Ichise ◽

Syunya Watanabe

Keyword(s):

Experimental Study ◽

Spherical Aberration ◽

Incident Beam ◽

Optical Parameters ◽

Beam Tilting ◽

Illumination Method ◽

Restoration Method ◽

Illumination Mode

The tilted beam illumination method is used to improve the resolution comparing with the axial illumination mode. Using this advantage, a restoration method of several tilted beam images covering the full azimuthal range was proposed by Saxton, and experimentally examined. To make this technique more reliable it seems that some practical problems still remain. In this report the restoration was attempted and the problems were considered. In our study, four problems were pointed out for the experiment of the restoration. (1) Accurate beam tilt adjustment to fit the incident beam to the coma-free axis for the symmetrical beam tilting over the full azimuthal range. (2) Accurate measurements of the optical parameters which are necessary to design the restoration filter. Even if the spherical aberration coefficient Cs is known with accuracy and the axial astigmatism is sufficiently compensated, at least the defocus value must be measured. (3) Accurate alignment of the tilt-azimuth series images.

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