Primary Extranodal Non-Hodgkin Lymphoma-A Rare Presentation as a Soft Tissue Mass

Rhinosporidiosis presents commonly as polypoidal growth in nose, but presentation in other sites including skin, genitourinary tract is documented. Cutaneous presentation is rare, which may present as pedunculated swelling or cutaneous ulceration, but presenting as soft tissue tumor is extremely rare. The multifaceted presentation of the disease causes diagnostic dilemma to an unsuspecting physician. Clinical and radiological findings may mislead, but usually typical history helps, and typical histology clinches the diagnosis. We are presenting a case of disseminated cutaneous rhinosporidiosis presented as soft tissue mass lesion in the leg causing diagnostic difficulty due to the rare presentation.

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Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm

BMJ Case Reports ◽

10.1136/bcr-2020-236856 ◽

2021 ◽

Vol 14 (2) ◽

pp. e236856

Author(s):

Susruta Manivannan ◽

Feras Sharouf ◽

George Lammie ◽

Paul Leach

Keyword(s):

Soft Tissue ◽

Soft Tissue Mass ◽

Neuroendocrine Tumour ◽

Clinical Findings ◽

Neuroendocrine Neoplasm ◽

Tumour Resection ◽

Rare Presentation ◽

Tissue Mass ◽

Left Hand ◽

History Of

Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.

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A Case Of Hodgkin Lymphoma Presenting As Soft Tissue Mass

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-1607028184 ◽

2017 ◽

Vol 16 (07) ◽

pp. 81-84

Author(s):

Dr. Daniel Ravikumar ◽

Dr. Rajeev Thilak C ◽

Dr. Ameesh Isath ◽

Dr. Nikitha Rafeek

Keyword(s):

Soft Tissue ◽

Hodgkin Lymphoma ◽

Soft Tissue Mass ◽

Tissue Mass

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Acute Promyelocytic Leukemia with FLT3/ITD and RUNX1 Mutation Presenting As Extramedullary Soft Tissue Mass

Blood ◽

10.1182/blood.v128.22.5185.5185 ◽

2016 ◽

Vol 128 (22) ◽

pp. 5185-5185

Author(s):

Shahram Mori ◽

Cai Yuan ◽

Wesam B. Ahmed ◽

Rushang D. Patel

Keyword(s):

Bone Marrow ◽

Soft Tissue ◽

Acute Promyelocytic Leukemia ◽

Soft Tissue Mass ◽

Promyelocytic Leukemia ◽

Myeloid Sarcoma ◽

Rare Presentation ◽

Tissue Mass ◽

Significant Information ◽

Runx1 Mutation

Abstract Background: APL formerly known as AML M3 is a variant of myeloid malignancies characterized by recurrent cytogenetic abnormality of PML/RARA translocation, t(15;17). Myeloid sarcoma, also called granulocytic sarcoma or chloroma, is a very rare presentation of extramedullary APL. In rare cases seen, it presents mainly as CNS disease in relapsed or refractory patients. Extramedullary APL on initial presentation is even rarer. As a result no significant information exists on the prognosis of such patients. Case report: A 50-year-old Caucasian female with no past medical history, presented with 6-month duration of chest pain, which was treated as costochondritis without any improvement. Three months later, a soft tissue mass was identified on her sternum. Complete blood count revealed pancytopenia with white blood cell 3.24 x 103/uL, hemoglobin 10.0 g/dL, platelets 58x 103/uL, absolute neutrophil count 1.13 x103/uL, and monocytes 0.13 x103/uL which indicated "low risk disease". A PET/CT scan revealed a 4.6 cm x 4 cm sternal soft tissue mass. The biopsy of the mass confirmed myeloid sarcoma. Bone marrow biopsy showed acute promyelocytic leukemia, approximately 20% blasts in a hypercellular marrow with 70-80% cellularity. Cytogenesis test was negative. FISH analysis subsequently showed a partial RARA transcript inserted at the PML locus suggestive of a cryptic PML/RARA. This was confirmed by PCR for the fusion transcript PML/RARA from the bone marrow. Next generation genome sequencing identified FLT3/ITD and RUNX1 mutation. The patient was treated as a high risk disease due to the presence of chloroma and immediately started on treatment with Daunorubicin, Arsenic Trioxide (ATO), and All-Trans-Retinoic Acid (ATRA). Conclusion: We present an extremely rare case of APL initially presenting with concomitant extramedullary sternal soft tissue mass with cryptic t(15;17) and somatic mutations in FLT/ITD as well as RUNX1 mutations. To our knowledge this is the first reported case of extramedullary APL with FLT/ITD and RUNX1 mutations. Early recognition of this rare presentation with timely chemotherapy may improve the outcomes of these patients. Disclosures No relevant conflicts of interest to declare.

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Giant epidermal cyst of the arm: a rare presentation

BMJ Case Reports ◽

10.1136/bcr-2018-227615 ◽

2018 ◽

Vol 11 (1) ◽

pp. e227615

Author(s):

Shaan Patel ◽

Key Yan Tsoi ◽

George Joseph

Keyword(s):

Soft Tissue ◽

Upper Extremity ◽

Surgical Resection ◽

Soft Tissue Mass ◽

Epidermal Cyst ◽

Lateral Aspect ◽

Rare Presentation ◽

Tissue Mass ◽

Slow Growing

A giant epidermal cyst is a benign soft tissue mass commonly involving the trunk, hand and face. The authors report a rare presentation of a 69-year-old man who presented with a painful, slow-growing left arm mass for 30 years duration. Examination revealed a large, mobile, soft tissue mass of the lateral aspect of the left arm. MRI showed a large, cystic left arm soft tissue mass. The mass was excised and the diagnosis of a giant epidermal cyst was made based on imaging and histopathology after surgical resection. The mass measured 9.5 cm x 8 cm x 4 cm, which is the largest reported giant epidermal cyst of the upper extremity.

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