Development and Evaluation of Controlled Release Bilayer Tablets of Hydrochlorothiazide and Losartan Potassium

The present investigation was focused on the development and evaluation of controlled release pellets of losartan potassium with Eudragit S 100 and hydroxypropyl methyl cellulose phthalate (HPMCP) by employing pan coating technique. Eudragit S 100, a high viscosity grade controlled release polymer, was mainly used as coating agent for regulating the drug release from pellets. HPMCP, an enteric coating polymer was used in the present study to regulate the drug release at varied G.I. pH conditions. The prepared pellets were evaluated for particle size, drug content, friability and for in vitro drug release. The formulations were further characterized to identify any possible interactions by FTIR spectroscopy and differential scanning calorimetry. The surface morphology of the pellets was studied by scanning electron microscopy. From the results it was observed that due to increase in the concentration of Eudragit the drug release was extended up to 12 hours. The increase in the HPMCP polymeric concentration in formulations showed initial delay in drug release.

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Bilayer Tablets Based on Poly (ε‐Caprolactone) and Polymethylmethacrilates as Controlled‐Release Systems for Ruminants

Pharmaceutical Development and Technology ◽

10.1081/pdt-200031453 ◽

2004 ◽

Vol 9 (3) ◽

pp. 321-328 ◽

Cited By ~ 1

Author(s):

Vanna Sanna ◽

Elisabetta Gavini ◽

Paolo Giunchedi

Keyword(s):

Controlled Release ◽

Bilayer Tablets

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DEVELOPMENT OF BILAYER TABLETS OF LOSARTAN POTASSIUM AND METFORMIN HYDROCHLORIDE LAYER USING NATURAL GUMS AS POLYMERS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i7.37797 ◽

2020 ◽

pp. 136-143

Author(s):

RAJYALAKSHMI KADIYAM ◽

KAVYA R

Keyword(s):

Drug Release ◽

Guar Gum ◽

Potato Starch ◽

Research Work ◽

Losartan Potassium ◽

Fickian Diffusion ◽

Metformin Hydrochloride ◽

Diabetic Patients ◽

Bilayer Tablets ◽

Fenugreek Gum

Objective: The aim of this research work was to develop and evaluate a bilayer formulation of losartan potassium and metformin hydrochloride for the treatment of diabetic patients with hypertension. In the present study, losartan potassium as immediate-release (IR) layer and metformin hydrochloride as a sustained-release (SR) layer were selected. Methods: The polymers selected were fenugreek gum, sweet potato starch, and ispaghula gum as natural disintegrants for IR layer and guar gum, xanthan gum, and pectin for SR layer. Bilayer tablets were developed by employing the two layers. Results: For IR layer, L4 formulation with 5% ispaghula gum as natural disintegrant showed 98.94% drug release was selected as an optimized layer. For sustained layer, F2 formulation with 18.75% guar gum as drug retardant showed 97.17% drug release was selected as optimized layer. Optimized formulation followed zero-order kinetics. When the release data was plotted into Higuchi and Korsmeyer-Peppas equations, then it was confirmed that the optimized formulation exhibited a Fickian diffusion type drug release. Conclusion: Tablets prepared with 5% ispaghula gum and 18.75% guar gums as drug retardants were found to be useful for bilayer tablet formulation with desired drug release characteristics.

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Optimal response surface design of Gum tragacanth-based poly[(acrylic acid)-co-acrylamide] IPN hydrogel for the controlled release of the antihypertensive drug losartan potassium

RSC Advances ◽

10.1039/c4ra02803a ◽

2014 ◽

Vol 4 (75) ◽

pp. 39822-39829 ◽

Cited By ~ 42

Author(s):

Saruchi Saruchi ◽

B. S. Kaith ◽

Rajeev Jindal ◽

Vaneet Kumar ◽

Manpreet S. Bhatti

Keyword(s):

Controlled Release ◽

Acrylic Acid ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Losartan Potassium ◽

Surface Design ◽

Gum Tragacanth ◽

Ph Conditions ◽

Poly Acrylic Acid

The present study proposes the development and optimization of a new interpenetrating polymer network (IPN), consisting of Gum tragacanth, poly(acrylic acid) (PAA), and poly(acrylamide) (PAAm), for the in situ controlled release of losartan potassium under different pH conditions at 37 °C.

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