Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)

As one member of PTPs, Src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) is mainly restricted to hematopoietic and epithelial cells and widely accepted as a convergent node for oncogenic...

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Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1634641 ◽

2019 ◽

Vol 38 (9) ◽

pp. 2509-2520 ◽

Cited By ~ 2

Author(s):

Wen-Shan Liu ◽

Rui-Rui Wang ◽

Wei-Ya Li ◽

Mei Rong ◽

Chi-Lu Liu ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Dynamics Simulation ◽

Loss Of Function ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105384 ◽

2021 ◽

pp. 105384

Author(s):

Xiang-Dong Meng ◽

Li-Xin Gao ◽

Zhi-Jia Wang ◽

Bo Feng ◽

Chun Zhang ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Oxadiazole Derivatives ◽

Src Homology 2 Domain ◽

Synthesis And Biological Evaluation

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Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2017.04.012 ◽

2017 ◽

Vol 487 (1) ◽

pp. 54-61 ◽

Cited By ~ 5

Author(s):

Yadhu Sharma ◽

Samina Bashir ◽

Ansarullah ◽

Mohemmed Faraz Khan ◽

Altaf Ahmad ◽

...

Keyword(s):

Insulin Resistance ◽

Protein Tyrosine Phosphatase ◽

High Fat Diet ◽

Tyrosine Phosphatase ◽

High Fat ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Chicken Ig-Like Receptor B2, a Member of a Multigene Family, Is Mainly Expressed on B Lymphocytes, Recruits Both Src Homology 2 Domain Containing Protein Tyrosine Phosphatase (SHP)-1 and SHP-2, and Inhibits Proliferation

The Journal of Immunology ◽

10.4049/jimmunol.173.12.7385 ◽

2004 ◽

Vol 173 (12) ◽

pp. 7385-7393 ◽

Cited By ~ 29

Author(s):

Birgit C. Viertlboeck ◽

Richard P. M. A. Crooijmans ◽

Martien A. M. Groenen ◽

Thomas W. F. Göbel

Keyword(s):

B Lymphocytes ◽

Protein Tyrosine Phosphatase ◽

Multigene Family ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2

Developmental & Comparative Immunology ◽

10.1016/j.dci.2008.10.006 ◽

2009 ◽

Vol 33 (4) ◽

pp. 570-582 ◽

Cited By ~ 19

Author(s):

Benjamin C.S. Montgomery ◽

Jacqueline Mewes ◽

Chelsea Davidson ◽

Deborah N. Burshtyn ◽

James L. Stafford

Keyword(s):

Cell Surface ◽

Channel Catfish ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Surface Expression ◽

Cell Surface Expression ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of Medicinal Chemistry ◽

10.1021/jm8002526 ◽

2008 ◽

Vol 51 (16) ◽

pp. 4948-4956 ◽

Cited By ~ 55

Author(s):

Harshani R. Lawrence ◽

Roberta Pireddu ◽

Liwei Chen ◽

Yunting Luo ◽

Shen-Shu Sung ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation

European Journal of Immunology ◽

10.1002/eji.200635864 ◽

2006 ◽

Vol 36 (12) ◽

pp. 3216-3226 ◽

Cited By ~ 16

Author(s):

Atsushi Fukunaga ◽

Hiroshi Nagai ◽

Xijun Yu ◽

Shuntaro Oniki ◽

Hideki Okazawa ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Langerhans Cell ◽

Cell Maturation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Phosphatase Substrate

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Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)

Immunology ◽

10.1111/j.1365-2567.2008.02929.x ◽

2008 ◽

Vol 127 (1) ◽

pp. 123-133 ◽

Cited By ~ 37

Author(s):

Julie Blanchette ◽

Issa Abu-Dayyeh ◽

Kasra Hassani ◽

Lorie Whitcombe ◽

Martin Olivier

Keyword(s):

Nitric Oxide ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Nitric Oxide Production ◽

Phosphotyrosine Phosphatase ◽

Protein Tyrosine ◽

Oxide Production ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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