Brachial-Ankle Pulse Wave Velocity Predicts Decline in Renal Function and Cardiovascular Events in Early Stages of Chronic Kidney Disease

Abstract Background Cardiovascular events are seen more frequently after the age of 60 and they are a significant cause of morbidity and mortality. Arterial stiffness is a property that can be expressed by pulse wave velocity and this value is assumed to be a predictor of cardiovascular events. Patients with chronic kidney disease and dysregulated blood sugar have increased atherosclerosis and arterial stiffness, but the relationship between physiological levels of Hba1c and arterial stiffness is less clear in chronic kidney disease patients without diabetes mellitus. Objectives Here, we aimed to investigate the degree of arterial stiffness among non-diabetic, non-dialysis dependent chronic kidney disease patients with physiological HbA1c levels. Methods We enrolled 51 patients who were followed up at Ege University Hospital Nephrology Department between February and June 2015. Non-diabetic, non-dialysis dependent chronic kidney disease patients were included in the study. Blood pressure and pulse wave velocity were measured with an applanation tonometry device (Sphygmocor Vx Software Atcor Medical, Australia). Correlations between pulse wave velocity and the aforementioned parameters were investigated (see below). Results We detected a significant correlation between pulse wave velocity and systolic blood pressure (p=0.0001) and Hba1c (p=0.044) separately. There was an inverse correlation with creatinine clearance (p=0.04). We also detected a significant correlation with serum phosphorus level (p=0.0077) and furosemide use (p=0.014). No correlations were found among the other parameters. Conclusions Arterial stiffness is an important predictor of cardiovascular events and measuring it is an inexpensive method for estimating morbidity and mortality. Our study supports the importance of measuring arterial stiffness and of controlling blood glucose levels, even at physiological Hba1c values, especially for chronic kidney disease patients.

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6.BRACHIAL-ANKLE PULSE WAVE VELOCITY AND CHRONIC KIDNEY DISEASE AS A PROGNOSTIC IMPACT IN HYPERTENSION

Artery Research ◽

10.1016/j.artres.2009.06.018 ◽

2009 ◽

Vol 3 (3) ◽

pp. 96 ◽

Cited By ~ 1

Author(s):

Miyuki Onishi ◽

Mitsuru Ohishi ◽

Takashi Takagi ◽

Yuji Tatara ◽

Nozomi Kato ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Prognostic Impact

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Association of Serum Cystatin C With Pulse Wave Velocity, But Not Pressure Wave Reflection, in Subjects With Normal Renal Function or Mild Chronic Kidney Disease

American Journal of Hypertension ◽

10.1038/ajh.2010.100 ◽

2010 ◽

Vol 23 (9) ◽

pp. 967-973 ◽

Cited By ~ 8

Author(s):

M. Odaira ◽

H. Tomiyama ◽

C. Matsumoto ◽

J. Yamada ◽

M. Yoshida ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Renal Function ◽

Kidney Disease ◽

Pulse Wave Velocity ◽

Normal Renal Function ◽

Pressure Wave ◽

Wave Reflection ◽

Pulse Wave ◽

Serum Cystatin C ◽

Serum Cystatin

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Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease

The Indonesian Biomedical Journal ◽

10.18585/inabj.v12i3.1241 ◽

2020 ◽

Vol 12 (3) ◽

pp. 267-74

Author(s):

Mochammad Yusuf Alsagaff ◽

Budi Susetyo Pikir ◽

Mochammad Thaha Thaha ◽

Hendri Susilo

Keyword(s):

Cardiovascular Disease ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Pulse Wave Velocity ◽

Serum Creatinine ◽

Antioxidant Capacity ◽

Wave Velocity ◽

Total Antioxidant Capacity ◽

Pulse Wave ◽

Total Antioxidant

BACKGROUND: Chronic kidney disease (CKD) is often associated with an increased risk of cardiovascular disease. Cardiovascular disease in CKD can be affected by oxidative stress and inflammation. The oxidative stress can affect arterial stiffness, especially in patients with CKD, which will increase the risk of cardiovascular disease. This study aimed to explain the correlation between total antioxidant capacity (TAC) and 8-hydroxydeoxyguanosine (8-OHdG) with carotid-femoral pulse wave velocity (cf-PWV) in patients with CKD.METHODS: Forty-three CKD patients was included in this cross-sectional study. TAC was measured from serum samples by colorimetric method and 8-OHDG was measured from urine by enzyme-linked immunoassay method. cf-PWV was measured by Doppler ultrasound as a diagnostic tool for arterial stiffness.RESULTS: Significant correlations were found between age, estimated glomerular filtration rate (e-GFR), Hemoglobin A1C (HbA1C), serum creatinine, cystatin-C, and severity of CKD with urinary 8-OHdG levels. Serum creatinine, cystatin-C, severity of CKD, age, high-density lipoprotein (HDL), e-GFR, and HbA1C also had significant correlations with serum TAC levels. Other significant correlations between e-GFR, HbA1C, serum creatinine, cystatin-C, and severity of CKD with cf-PWV were also obtained. A significant negative correlation was obtained between serum TAC and cf-PWV with moderate levels of correlation coefficient (r=-0.504).CONCLUSION: There was a negative correlation between TAC and cf-PWV, but there was no significant correlation between 8-OHdG and cf-PWV in patients with CKD.KEYWORDS: chronic kidney disease, total antioxidant capacity, 8-hydroxydeoxyguanosine, carotid-femoral pulse wave velocity

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