scholarly journals Molecular ultrasound imaging of neutrophil membrane-derived biomimetic microbubbles for quantitative evaluation of hepatic ischemia-reperfusion injury

Theranostics ◽  
2021 ◽  
Vol 11 (14) ◽  
pp. 6922-6935
Author(s):  
Zheng Zhang ◽  
Xiaoyan Miao ◽  
Weifeng Yao ◽  
Jie Ren ◽  
Chaojin Chen ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Quantitative Evaluation ◽  
Ultrasound Imaging ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Molecular Ultrasound ◽  
Hepatic Ischemia Reperfusion

scholarly journals Ultrasound Imaging Based on Molecular Targeting for Quantitative Evaluation of Hepatic Ischemia-Reperfusion Injury

2017 ◽  
Vol 17 (12) ◽  
pp. 3087-3097 ◽  
Author(s):  
C. Qiu ◽  
T. Yin ◽  
Y. Zhang ◽  
Y. Lian ◽  
Y. You ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Quantitative Evaluation ◽  
Ultrasound Imaging ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Molecular Targeting ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway

Cytokine ◽  
2021 ◽  
Vol 141 ◽  
pp. 155429
Author(s):  
Fang-fang Li ◽  
Xin Zhou ◽  
Shi-feng Chu ◽  
Nai-hong Chen
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Mapk Pathway ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Ying Dong Du ◽  
Wen Yuan Guo ◽  
Cong Hui Han ◽  
Ying Wang ◽  
Xiao Song Chen ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mitochondrial Fragmentation ◽  
Hepatic Ischemia ◽  
Adeno Associated Virus ◽  
Downstream Target ◽  
Hepatic Ischemia Reperfusion

AbstractDespite N6-methyladenosine (m6A) is functionally important in various biological processes, its role and the underlying regulatory mechanism in the liver remain largely unexplored. In the present study, we showed that fat mass and obesity-associated protein (FTO, an m6A demethylase) was involved in mitochondrial function during hepatic ischemia–reperfusion injury (HIRI). We found that the expression of m6A demethylase FTO was decreased during HIRI. In contrast, the level of m6A methylated RNA was enhanced. Adeno-associated virus-mediated liver-specific overexpression of FTO (AAV8-TBG-FTO) ameliorated the HIRI, repressed the elevated level of m6A methylated RNA, and alleviated liver oxidative stress and mitochondrial fragmentation in vivo and in vitro. Moreover, dynamin-related protein 1 (Drp1) was a downstream target of FTO in the progression of HIRI. FTO contributed to the hepatic protective effect via demethylating the mRNA of Drp1 and impairing the Drp1-mediated mitochondrial fragmentation. Collectively, our findings demonstrated the functional importance of FTO-dependent hepatic m6A methylation during HIRI and provided valuable insights into the therapeutic mechanisms of FTO.

scholarly journals SIRT1 Alleviates Hepatic Ischemia-Reperfusion Injury Via the miR-182-Mediated XBP1/NLRP3 Pathway

2020 ◽  
Author(s):  
Fengwei Li ◽  
Lei Zhang ◽  
Hui Xue ◽  
Jianbing Xuan ◽  
Shu Rong ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia–reperfusion injury in rats

2012 ◽  
Vol 40 (4) ◽  
pp. 1279-1290 ◽  
Author(s):  
Cheuk-Kwan Sun ◽  
Chia-Lo Chang ◽  
Yu-Chun Lin ◽  
Ying-Hsien Kao ◽  
Li-Teh Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Systemic Administration ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion
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