Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia–reperfusion injury in rats

2012 ◽  
Vol 40 (4) ◽  
pp. 1279-1290 ◽  
Author(s):  
Cheuk-Kwan Sun ◽  
Chia-Lo Chang ◽  
Yu-Chun Lin ◽  
Ying-Hsien Kao ◽  
Li-Teh Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Systemic Administration ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals Fate and Effect of Intravenously Infused Mesenchymal Stem Cells in a Mouse Model of Hepatic Ischemia Reperfusion Injury and Resection

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
T. C. Saat ◽  
S. van den Engel ◽  
W. Bijman-Lachger ◽  
S. S. Korevaar ◽  
M. J. Hoogduijn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Weight Ratio ◽  
Hepatocellular Injury ◽  
Hepatic Ischemia ◽  
Beneficial Effects ◽  
Hepatic Ischemia Reperfusion

Liver ischemia reperfusion injury (IRI) is inevitable during transplantation and resection and is characterized by hepatocellular injury. Therapeutic strategies to reduce IRI and accelerate regeneration could offer major benefits. Mesenchymal stem cells (MSC) are reported to have anti-inflammatory and regeneration promoting properties. We investigated the effect of MSC in a model of combined IRI and partial resection in the mouse. Hepatic IRI was induced by occlusion of 70% of the blood flow during 60 minutes, followed by 30% hepatectomy. 2 × 105MSC or PBS were infused 2 hours before or 1 hour after IRI. Six, 48, and 120 hours postoperatively mice were sacrificed. Liver damage was evaluated by liver enzymes, histology, and inflammatory markers. Regeneration was determined by liver/body weight ratio, proliferating hepatocytes, and TGF-βlevels. Fate of MSC was visualized with 3D cryoimaging. Infusion of 2 × 105MSC 2 hours before or 1 hour after IRI and resection showed no beneficial effects. Tracking revealed that MSC were trapped in the lungs and did not migrate to the site of injury and many cells had already disappeared 2 hours after infusion. Based on these findings we conclude that intravenously infused MSC disappear rapidly and were unable to induce beneficial effects in a clinically relevant model of IRI and resection.

scholarly journals Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury

2017 ◽  
Vol 23 (6) ◽  
pp. 791-803 ◽  
Author(s):  
Hiroaki Haga ◽  
Irene K. Yan ◽  
David A. Borrelli ◽  
Akiko Matsuda ◽  
Mansi Parasramka ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Extracellular Vesicles ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Equal distribution of mesenchymal stem cells after hepatic ischemia–reperfusion injury

2016 ◽  
Vol 203 (2) ◽  
pp. 360-367 ◽  
Author(s):  
Askhat Isbambetov ◽  
Zhassulan Baimakhanov ◽  
Akihiko Soyama ◽  
Masaaki Hidaka ◽  
Yusuke Sakai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Equal Distribution ◽  
Hepatic Ischemia Reperfusion

scholarly journals Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Hepatic Ischemia Reperfusion Injury in a Rat Model

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e19195 ◽  
Author(s):  
Hiroyuki Kanazawa ◽  
Yasuhiro Fujimoto ◽  
Takumi Teratani ◽  
Junji Iwasaki ◽  
Naoya Kasahara ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion
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