METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication

Abstract. Background: Effectiveness of vascular closure devices during endovascular procedures requiring a direct puncture of a vascular prosthesis placed in the inguinal region is unknown. Patients and methods: The retrospective analysis included 134 patients with a history of polyethylene terephthalate (PETE) graft implantation in the inguinal region. In 20 (15 %) patients, haemostasis was achieved with manual compression, in 21 (16 %) with the StarClose™, and in 93 (69 %) with the AngioSeal™ device. Results: The incidence of vascular complications in the manual compression group was higher (at a threshold of statistical significance) than in the device closure group (45.0 vs. 24.5 %, p = 0.059). The difference was considered statistically significant when manual compression was compared with the AngioSeal™ closure group (45.0 vs. 13.9 %, p < 0.01). The vascular complication rate in the StarClose™ group was significantly higher than in the AngioSeal™ group (71.4 vs. 13.9 %, p < 0.000001). While haematomas were the only vascular complications observed after application of AngioSeal™, both haematomas and pseudoaneurysms were found in the StarClose™ group. Conclusions: The AngioSeal™ vascular closure device provides better local haemostasis than the StarClose™ device or manual compression during endovascular interventions requiring a direct puncture of PETE grafts

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Doppler US Findings of Vascular Complication after Liver Transplantation

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2000.42.2.311 ◽

2000 ◽

Vol 42 (2) ◽

pp. 311

Author(s):

Dong Jin Jung ◽

Pyo Nyun Kim ◽

Hyun Kwon Ha ◽

Mun Gyu Lee ◽

Yong Ho Auh

Keyword(s):

Liver Transplantation ◽

Vascular Complication ◽

Doppler Us ◽

Us Findings

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Does Vitamin K Intake Influence High Phosphate Induced Vascular Pseudo-ossification: An Underappreciated Therapeutic Prospect in General Population?

Current Drug Targets ◽

10.2174/1389450119666181031124430 ◽

2019 ◽

Vol 20 (4) ◽

pp. 421-430

Author(s):

Zar Chi Thent ◽

Gabriele R.A. Froemming ◽

Suhaila Abd Muid

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Vascular Calcification ◽

Vitamin K ◽

Prolonged Exposure ◽

Vascular Complication ◽

Key Factors ◽

The Matrix ◽

Underlying Mechanisms ◽

High Phosphate

Increasing interest in vascular pseudo-ossification has alarmed the modern atherosclerotic society. High phosphate is one of the key factors in vascular pseudo ossification, also known as vascular calcification. The active process of deposition of the phosphate crystals in vascular tissues results in arterial stiffness. High phosphate condition is mainly observed in chronic kidney disease patients. However, prolonged exposure with high phosphate enriched foods such as canned drinks, dietary foods, etc. can be considered as modifiable risk factors for vascular complication in a population regardless of chronic kidney disease. High intake of vitamin K regulates the vascular calcification by exerting its anti-calcification effect. The changes in serum phosphate and vitamin K levels in a normal individual with high phosphate intake are not well investigated. This review summarised the underlying mechanisms of high phosphate induced vascular pseudo ossification such as vascular transdifferentiation, vascular apoptosis and phosphate uptake by sodium-dependent co-transporters. Pubmed, Science Direct, Scopus, ISI Web of Knowledge and Google Scholar were searched using the terms ‘vitamin K’, ‘vascular calcification, ‘phosphate’, ‘transdifferentiation’ and ‘vascular pseudoossification’. Vitamin K certainly activates the matrix GIA protein and inhibits vascular transition and apoptosis in vascular pseudo-ossification. The present view highlighted the possible therapeutic linkage between vitamin K and the disease. Understanding the role of vitamin K will be considered as potent prophylaxis agent against the vascular disease in near future.

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Dose approach matter? A meta-analysis of outcomes following transfemoral versus transapical transcatheter aortic valve replacement

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02158-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ruikang Guo ◽

Minghui Xie ◽

Wai Yen Yim ◽

Wenconghui Wu ◽

Weiwei Jiang ◽

...

Keyword(s):

Acute Kidney Injury ◽

Aortic Valve ◽

Transcatheter Aortic Valve Replacement ◽

Observational Studies ◽

Meta Analysis ◽

Kidney Injury ◽

Vascular Complication ◽

Permanent Pacemaker ◽

Transcatheter Aortic Valve ◽

Effect Model

Abstract Background Transcatheter aortic valve replacement (TAVR) has gained increasing acceptance for patients with aortic disease. Both transfemoral (TF-TAVR) and transapical (TA-TAVR) approach were widely adopted while their performances are limited to a few studies with controversial results. This meta-analysis aimed to compare the mortality and morbidity of complications between TF- versus TA-TAVR based on the latest data. Methods Electronic databases were searched until April 2021. RCTs and observational studies comparing the outcomes between TF-TAVR versus TA-TAVR patients were included. Heterogeneity assumption was assessed by an I2 test. The pooled odds ratios(OR) or mean differences with corresponding 95% confidence intervals (CI) were used to evaluate the difference for each end point using a fixed-effect model or random-effect model based on I2 test. Results The meta-analysis included 1 RCT and 20 observational studies, enrolling 19,520 patients (TF-TAVR, n = 11,986 and TA-TAVR, n = 7,534). Compared with TA-TAVR, TF-TAVR patients showed significantly lower rate of postoperative in-hospital death (OR = 0.67, 95% CI 0.59–0.77, P < 0.001) and 1-year death (OR = 0.53, 95% CI 0.41–0.69, P < 0.001). Incidence of major bleeding and acute kidney injury were lower and length of hospital stay was shorter, whereas those of permanent pacemaker and major vascular complication were higher in TF-TAVR patients. There were no significant differences between TF-TAVR versus TA-TAVR for stroke and mid-term mortality. Conclusions There were fewer early deaths in patients with transfemoral approach, whereas the number of mid-term deaths and stroke was not significantly different between two approaches. TF-TAVR was associated with lower risk of bleeding, acute kidney injury as well as shorter in-hospital stay, but higher incidence of vascular complication and permanent pacemaker implantation.

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Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/10760296211010260 ◽

2021 ◽

Vol 27 ◽

pp. 107602962110102

Author(s):

Łukasz Nawacki ◽

Jarosław Matykiewicz ◽

Ewa Stochmal ◽

Stanisław Głuszek

Keyword(s):

Acute Pancreatitis ◽

Severe Disease ◽

Vascular Complication ◽

Strong Positive Correlation ◽

Splanchnic Vein Thrombosis ◽

Vein Thrombosis ◽

Computed Tomography Scans ◽

Negative Effect ◽

Medical Histories ◽

The Impact

Splanchnic vein thrombosis (SVT) is a serious vascular complication that can occur in patients with acute pancreatitis. We assessed the incidence of SVT and its relationship with acute pancreatitis (AP) and associated complications. We carried out a retrospective analysis of medical histories from patients hospitalized with AP in a single surgical center. Histories were acquired from patients with abdominal and pelvic computed tomography scans performed between the 2nd and 3rd day of hospitalization. We assessed the impact and extent of thrombosis over the disease course. We found a strong positive correlation (Cramer’s V coefficient = 0.34) between SVT and disease severity. Mortality in the study group was 7.2% (8 patients) of which 5 patients (62.5%) were diagnosed with SVT. We observed an increased incidence of death among patients with thrombosis, with results approaching significance ( P = 0.056). In our study, we found that SVT has a negative effect on the course of AP and is associated with more severe disease and increased mortality.

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Pancreatic Pseudoaneurysm from a Gastroduodenal Artery

Case Reports in Gastroenterology ◽

10.1159/000503895 ◽

2019 ◽

Vol 13 (3) ◽

pp. 450-455 ◽

Cited By ~ 1

Author(s):

Dhineshreddy Gurala ◽

Abhishek Datta Polavarapu ◽

Pretty Sara Idiculla ◽

Magda Daoud ◽

Vivek Gumaste

Keyword(s):

Acute Pancreatitis ◽

Gastric Bypass ◽

Coil Embolization ◽

Bypass Surgery ◽

Gastric Bypass Surgery ◽

Vascular Complication ◽

Gastroduodenal Artery ◽

Unique Case ◽

Fatal Complications

Pancreatic pseudoaneurysm is a rare vascular complication of pancreatitis, resulting from erosion of the pancreatic or peripancreatic artery into a pseudocyst. However, it may happen after pancreatic or gastric bypass surgery or trauma. It may lead to fatal complications if left untreated. Herein, we report a unique case of pseudoaneurysm from a gastroduodenal artery in a patient with recurrent episodes of acute pancreatitis, which was managed successfully with coil embolization.

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Procedural Safety and Potential Vascular Complication of Endovascular Recanalization for Chronic Cervical Internal Carotid Artery Occlusion

Circulation Cardiovascular Interventions ◽

10.1161/circinterventions.108.772350 ◽

2008 ◽

Vol 1 (2) ◽

pp. 119-125 ◽

Cited By ~ 52

Author(s):

Mao-Shin Lin ◽

Lung-Chun Lin ◽

Hung-Yuan Li ◽

Cheng-Hsin Lin ◽

Chi-Chao Chao ◽

...

Keyword(s):

Carotid Artery ◽

Internal Carotid Artery ◽

Internal Carotid ◽

Artery Occlusion ◽

Carotid Artery Occlusion ◽

Vascular Complication ◽

Internal Carotid Artery Occlusion ◽

Endovascular Recanalization ◽

Cervical Internal Carotid Artery

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Complete percutaneous angio-guided implantation and explantation of VA-ECMO using preclosing for cardiogenic shock or cardiac arrest

European Heart Journal Acute Cardiovascular Care ◽

10.1093/ehjacc/zuab020.209 ◽

2021 ◽

Vol 10 (Supplement_1) ◽

Author(s):

R Gallet ◽

AS Martin-Tuffreau ◽

F Bagate ◽

M Boukantar ◽

G Saiydoun ◽

...

Keyword(s):

Cardiac Arrest ◽

Cardiogenic Shock ◽

Vascular Complications ◽

Vascular Complication ◽

Vascular Intervention ◽

Technical Success Rate ◽

Surgical Closure ◽

Refractory Cardiogenic Shock ◽

Distal Perfusion ◽

Va Ecmo

Abstract Funding Acknowledgements Type of funding sources: None. Background. The approach for veno-arterial extracorporeal membrane oxygenation implantation (VA-ECMO) in patients with cardiogenic shock can be either surgical or percutaneous. Angio-guided percutaneous implantation and explantation could decrease vascular complications. Purpose We sought to describe the feasibility and safety of complete percutaneous angio-guided ECMO implantation and explantation using preclosing. Methods. All consecutive patients who underwent peripheral femoro-femoral VA-ECMO percutaneous implantation for refractory cardiogenic shock or cardiac arrest were enrolled in a prospective registry (03/2018-09/2020). Percutaneous preclosing using two closing devices (Perclose ProGlide, Abbott) inserted before cannulation was used in both femoral artery and vein. Explantation was performed using a crossover technique under fluoroscopic guidance. The occurrence of vascular complication was recorded. Results. Forty-nine patients underwent percutaneous VA-ECMO implantation for cardiogenic shock (n = 36) or refractory cardiac arrest (n = 13). Femoral vessel cannulations were successful in all patients and total cannulation time was 21± 8 min. Weaning from ECMO was possible in 23 patients (47%) and 11 (22%) patients were alive at 30-day. Significant vascular complications occurred in 3 patients (6%); all were related to distal perfusion line. One patient experienced major bleeding, and 2 experienced lower limb ischemia requiring vascular intervention (one failure of distal perfusion sheath implantation and one self-uprooting of the reperfusion cannula). Percutaneous decannulation was performed in 17 patients with 16/17 technical success rate. All femoral arteries and veins were properly closed using the pre-closing devices without bleeding on the angiographic control except for one patient in whom surgical closure of the artery was required. Among these patients, none required transfusion for access related significant bleeding and no other vascular complication occurred. Furthermore, no groin infection was observed after full percutaneous implantation and removal of ECMO. Conclusion. Emergent complete percutaneous angio-guided VA-ECMO implantation and explantation using pre-closing technique is an effective and safe strategy in patients referred for refractory cardiogenic shock or cardiac arrest.

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