scholarly journals In situ gamma-ray measurements of 40K, 232Th and 238U in high-grade metamorphic rocks from the Sowie Mountains (Sudetes, SW Poland)

2019 ◽  
Author(s):  
Dariusz MALCZEWSKI ◽  
Jerzy ŻABA
Keyword(s):  
Gamma Ray ◽  
Metamorphic Rocks ◽  
High Grade ◽  
Sw Poland

Deconvolving gamma-ray logs by adaptive zone refinement

Geophysics ◽  
2012 ◽  
Vol 77 (4) ◽  
pp. D159-D169 ◽  
Author(s):  
B. Dickson ◽  
M. Craig
Keyword(s):  
Gamma Ray ◽  
High Grade ◽  
Space Domain ◽  
Uranium Ore ◽  
Uranium Exploration ◽  
The Usa ◽  
Very High ◽  
Ore Grade ◽  
Adaptive Zone

Uranium exploration and mining make widespread use of gamma-ray logs to determine ore-grade distribution in situ. Attenuation, scattering, and uncollimated detectors all degrade the signal, hampering accuracy. We deconvolve their effects from the measured logs by space-domain processing with the aid of a function that takes account of detector length and uranium ore-zone thickness. The output quantifies uranium grade by zones of specified location and thickness. With this method, thin zones of very high grade can be used for calibration. Illustrative data come from model pits in Australia, Canada, and the USA.

Unravelling the enigmatic Grampian Shear Zone: In-situ monazite and titanite U-Pb analysis of the juxtaposed Badenoch and Grampian Groups

2021 ◽  
Author(s):  
Lewis Evason ◽  
Anna Bird ◽  
Eddie Dempsey ◽  
Kit Hardman ◽  
Martin Smith ◽  
...  
Keyword(s):  
Shear Zone ◽  
Major Elements ◽  
Metamorphic Rocks ◽  
High Grade ◽  
Icp Ms ◽  
Wide Range ◽  
Caledonian Orogeny ◽  
Detailed Picture ◽  
Spot Analysis

<p>The Grampian Shear Zone (GSZ) represents a highly deformed tectonostratigraphic contact between the Proterozoic metamorphic rocks of the Dalradian Group from the underlying high grade metamorphic Neoproterozoic rocks of the Badenoch Group within the Grampian Highlands. The nature (tectonic suture or palaeo-unconformity), age and structure of the GSZ and indeed the underling Badenoch Group are poorly constrained. Previous studies of the GSZ and synkinematic (intruded during shearing) pegmatites found therein, yielded metamorphic/deformation (and magmatic) ages ranging from c.a. 808 to 440 M. This study reinvestigates this shearzone using in-situ (within section) petrochonological analysis on a range of U-Pb and Rb-Sr chronometers – Monazite, zircon, titanite, rutile and mica. Carrying out this analysis in-situ and using a variety of minerals allows us to directly date deformation fabrics over a wide range of deformation temperatures, giving us a far more detailed picture of the events recorded within these rocks. Large monazite grains (≥100μm) were mapped using in-situ LA-ICP-MS to show within grain variation of major elements and REEs. Monazite U-Pb spot analysis from the GSZ has yielded ages ranging from 784.11 ± 1.2Ma to 442.58 ± 0.58Ma. The same analysis was performed on a sample from the Grampian group which yielded an age of 441.34 ± 037Ma. In addition to this monazite data, in-situ U-Pb Titanite analysis from the Badenoch Group gave ages of 526.96 ± 1.33 Ma from a metabasite sample, with a metasedimentary sample giving a range of titanite U Pb ages from 540 to 460Ma. These age ranges show that the Badnoch Group and the GSZ have recorded a complex polyorogenic history relative to the “simple” overlying Dalradian metasediments. We propose that the Grampian Shear Zone represents a deep-seated Knoydartian (808 to 784Ma) age shear zone within the meso-Neoproterozoic Badenoch Group. This shear zone was then reactivated during the Grampian phase of the Caledonian Orogeny resulting in the tectonic emplacement of the Dalradian metasediments above the Badenoch group.</p>

Metody cytogenetyki molekularnej w różnicowaniu agresywnych B-NHL

2019 ◽  
Vol 50 (3) ◽  
pp. 109-115
Author(s):  
Beata Grygalewicz
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
World Health ◽  
High Grade ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell Lymphoma ◽  
Health Organization ◽  
Large B Cell

StreszczenieB-komórkowe agresywne chłoniaki nieziarnicze (B-cell non-Hodgkin lymphoma – B-NHL) to heterogenna grupa nowotworów układu chłonnego, wywodząca się z obwodowych limfocytów B. Aberracje cytogenetyczne towarzyszące B-NHL to najczęściej translokacje onkogenów takich jak MYC, BCL2, BCL6 w okolice genowych loci dla łańcuchów ciężkich lub lekkich immunoglobulin. W niektórych przypadkach dochodzi do wystąpienia kilku wymienionych aberracji jednocześnie, tak jak w przypadkach przebiegających z równoczesną translokacją genów MYC i BCL2 (double hit), niekiedy także z obecnością rearanżacji BCL6 (triple hit). Takie chłoniaki cechuje szczególnie agresywny przebieg kliniczny. Obecnie molekularna diagnostyka cytogenetyczna przy użyciu techniki fluorescencyjnej hybrydyzacji in situ (FISH) oraz, w niektórych przypadkach, aCGH jest niezbędnym narzędziem rozpoznawania, klasyfikowania i oceny stopnia zaawansowania agresywnych, nieziarniczych chłoniaków B-komórkowych. Technika mikromacierzy CGH (aCGH) była kluczowym elementem wyróżnienia prowizorycznej grupy chłoniaków Burkitt-like z aberracją chromosomu 11q (Burkitt-like lymphoma with 11q aberration – BLL, 11q) w najnowszej klasyfikacji nowotworów układu chłonnego Światowej Organizacji Zdrowia (World Health Organization – WHO) z 2016 r. Omówione zostaną sposoby różnicowania na poziomie cytogenetycznym takich chłoniaków jak: chłoniak Burkitta (Burkitt lymphoma – BL), chłoniak rozlany z dużych komórek B (diffuse large B-cell lymphoma – DLBCL) oraz 2 nowych jednostek klasyfikacji WHO 2016, czyli chłoniaka z komórek B wysokiego stopnia złośliwości z obecnością translokacji MYC i BCL2 i/lub BCL6 (high-grade B-cell lymphoma HGBL, with MYC and BCL2 and/or BCL6 translocations) oraz chłoniaka BLL, 11q.

scholarly journals In-situ gamma-ray background measurements for next generation CDEX experiment in the China Jinping Underground Laboratory

2021 ◽  
Vol 128 ◽  
pp. 102560
Author(s):  
H. Ma ◽  
Z. She ◽  
W.H. Zeng ◽  
Z. Zeng ◽  
M.K. Jing ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Underground Laboratory ◽  
Next Generation

scholarly journals Expression of Semaphorin 3A in Malignant and Normal Bladder Tissue: Immunohistochemistry Staining and Morphometric Evaluation

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 109
Author(s):  
Ilan Bejar ◽  
Jacob Rubinstein ◽  
Jacob Bejar ◽  
Edmond Sabo ◽  
Hilla K Sheffer ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Carcinoma In Situ ◽  
Urothelial Cancer ◽  
Basal Layer ◽  
Low Grade ◽  
High Grade ◽  
Bladder Tissue ◽  
Normal Bladder ◽  
Normal Bladder Tissue

Introduction: Our previous studies showed elevated levels of Semaphorin3a (Sema3A) in the urine of patients with urothelial cancer compared to healthy patients. The aim of this study was to analyze the extent of Sema3A expression in normal and malignant urothelial tissue using immune-staining microscopic and morphometric analysis. Materials and Methods: Fifty-seven paraffin-embedded bladder samples were retrieved from our pathology archive and analyzed: 14 samples of normal urothelium, 21 samples containing low-grade urothelial carcinoma, 13 samples of patients with high-grade urothelial carcinoma, 7 samples containing muscle invasive urothelial carcinoma, and 2 samples with pure urothelial carcinoma in situ. All samples were immunostained with anti Sema3A antibodies. The area of tissue stained with Sema3A and its intensity were analyzed using computerized morphometry and compared between the samples’ groups. Results: In normal bladder tissue, very light Sema3A staining was demonstrated on the mucosal basal layer and completely disappeared on the apical layer. In low-grade tumor samples, cells in the basal layer of the mucosa were also lightly stained with Sema3A, but Seama3A expression intensified upon moving apically, reaching its highest level on apical cells exfoliating to the urine. In high grade urothelial tumors, Seama3A staining was intense in the entire thickness of the mucosa. In samples containing carcinoma in situ, staining intensity was high and homogenous in all the neoplastic cells. Conclusions: Sema3A may be serve as a potential non-invasive marker of urothelial cancer.

scholarly journals Patterns of invasive recurrence among patients originally treated for ductal carcinoma in situ by breast-conserving surgery versus mastectomy

2021 ◽  
Vol 186 (3) ◽  
pp. 617-624
Author(s):  
Kate R. Pawloski ◽  
Audree B. Tadros ◽  
Varadan Sevilimedu ◽  
Ashley Newman ◽  
Lori Gentile ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Advanced Disease ◽  
Breast Conserving Surgery ◽  
Risk Profile ◽  
High Grade ◽  
Group A ◽  
First Recurrence

Abstract Purpose Local recurrence after treatment of ductal carcinoma in situ (DCIS) with breast-conserving surgery (BCS) is more common than after mastectomy, but it is unclear if patterns of invasive recurrence vary by initial surgical therapy. Among patients with invasive recurrence after treatment for DCIS, we compared patterns of first recurrence between those originally treated with BCS vs. mastectomy. Methods From 2000 to 2016, women with an invasive recurrence occurring ≥ 6 months after initial treatment for DCIS were retrospectively identified. Clinicopathologic features and adjuvant treatment of the initial DCIS, as well as characteristics of first invasive recurrences, were compared between patients who had undergone BCS vs. mastectomy. Results 452 patients with an invasive recurrence after surgery for DCIS were identified: 367 patients (81%) had initially undergone BCS and 85 patients (19%) mastectomy. Patients originally treated with mastectomy were younger and were more likely to have had high grade, necrosis, and multifocal or multicentric DCIS (p < 0.001) compared with the BCS group. A higher proportion of invasive recurrences were local after BCS (93%; 343/367), whereas 88% (75/85) of recurrences after mastectomy were regional or distant (p < 0.001). The median time to first invasive recurrence was not different between surgical groups (BCS: 6.4 years vs. mastectomy: 5.5 years; p = 0.12). Conclusions Among women who experienced a first invasive recurrence after treatment for DCIS, those who had originally undergone mastectomy more commonly presented with advanced disease compared to those treated with BCS, likely related to the absence of the breast and the higher risk profile of their initial DCIS.

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