PART TWO: THE DISCOVERY PROCESS

2021 ◽  
pp. 31-92
Keyword(s):  
Discovery Process

Exchange and Specialization as a Discovery Process

2006 ◽  
Author(s):  
Sean Crockett ◽  
Vernon L. Smith ◽  
Bart J. Wilson
Keyword(s):  
Discovery Process

Sugars that Glow in the Dark: Fluorescent Tagged Glucose Bioprobes and their Facilitation of the Drug Discovery Process

2015 ◽  
Vol 22 (15) ◽  
pp. 1793-1807 ◽  
Author(s):  
JungIn Um ◽  
JiHyung Lee ◽  
Da-Woon Jung ◽  
Darren Williams
Keyword(s):  
Drug Discovery ◽  
Discovery Process ◽  
Drug Discovery Process

ReAction!

2009 ◽  
Author(s):  
Mark A. Griep ◽  
Marjorie L. Mikasen
Keyword(s):  
Drug Discovery ◽  
Chemical Weapons ◽  
Trial And Error ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
Special Effects ◽  
Invisible Man ◽  
Feature Films ◽  
The World ◽  
Chemical Companies

ReAction! gives a scientist's and artist's response to the dark and bright sides of chemistry found in 140 films, most of them contemporary Hollywood feature films but also a few documentaries, shorts, silents, and international films. Even though there are some examples of screen chemistry between the actors and of behind-the-scenes special effects, this book is really about the chemistry when it is part of the narrative. It is about the dualities of Dr. Jekyll vs. inventor chemists, the invisible man vs. forensic chemists, chemical weapons vs. classroom chemistry, chemical companies that knowingly pollute the environment vs. altruistic research chemists trying to make the world a better place to live, and, finally, about people who choose to experiment with mind-altering drugs vs. the drug discovery process. Little did Jekyll know when he brought the Hyde formula to his lips that his personality split would provide the central metaphor that would come to describe chemistry in the movies. This book explores the two movie faces of this supposedly neutral science. Watching films with chemical eyes, Dr. Jekyll is recast as a chemist engaged in psychopharmaceutical research but who becomes addicted to his own formula. He is balanced by the often wacky inventor chemists who make their discoveries by trial-and-error.

scholarly journals Partitioning Pattern of Natural Products Based on Molecular Properties Descriptors Representing Drug-Likeness

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 546
Author(s):  
Miroslava Nedyalkova ◽  
Vasil Simeonov
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
De Novo ◽  
Target Prediction ◽  
Natural Compounds ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
Unique Source ◽  
The Times ◽  
Partitioning Pattern

A cheminformatics procedure for a partitioning model based on 135 natural compounds including Flavonoids, Saponins, Alkaloids, Terpenes and Triterpenes with drug-like features based on a descriptors pool was developed. The knowledge about the applicability of natural products as a unique source for the development of new candidates towards deadly infectious disease is a contemporary challenge for drug discovery. We propose a partitioning scheme for unveiling drug-likeness candidates with properties that are important for a prompt and efficient drug discovery process. In the present study, the vantage point is about the matching of descriptors to build the partitioning model applied to natural compounds with diversity in structures and complexity of action towards the severe diseases, as the actual SARS-CoV-2 virus. In the times of the de novo design techniques, such tools based on a chemometric and symmetrical effect by the implied descriptors represent another noticeable sign for the power and level of the descriptors applicability in drug discovery in establishing activity and target prediction pipeline for unknown drugs properties.

Balancing Agency with Structure: Institutional Entrepreneurship as an Embedded Discovery Process

2021 ◽  
pp. 239395752110106
Author(s):  
Desmond Ng
Keyword(s):  
Social Group ◽  
The Other ◽  
Discovery Process ◽  
Institutional Entrepreneurship ◽  
Dual Structure ◽  
Entrepreneurship Research ◽  
Social Settings ◽  
Institutional Researchers

While mainstream research has treated entrepreneurship as a highly individualised and agentic process, institutional researchers contend that entrepreneurship operates within a greater embedded setting. Various researchers have appealed to Giddens’ dual structure to explain an entrepreneur’s embedded-agency. According to Giddens’ dual structure, this embedded-agency consists of the rules or norms of a social group in which these rules constrain and enable an entrepreneur’s resources. Yet, despite Giddens’ contributions, Giddens is criticised for conflating the rules of this embedded setting with an entrepreneur’s resources in which neither affects the other in any significant way. By drawing on concepts of the Austrian entrepreneur and embeddedness, a theory of institutional entrepreneurship is developed to address this conflation problem. This institutional entrepreneurship offers an embedded-agency to explain how an entrepreneur can create, maintain and disrupt their embedded social settings. This embedded-agency addresses Giddens’ conflation problem and broadens the agent-centric focus of institutional entrepreneurship research.

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