Association Between the XRCC3 T241M Polymorphism and Head and Neck Cancer Susceptibility: a Meta-analysis of Case-control Studies

Background. The role of theNFKB1gene rs28362491 polymorphism andNFKBIAgene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively.Methods. PubMed, Embase, Web of Science, WanFang Data, and China National Knowledge databases were used to search for eligible articles. The relationship was evaluated by STATA 11.0.Results. Eight eligible articles were included in our study. Nine case-control studies from the eight included articles were correlated with rs28362491 polymorphism. Four articles were related to rs2233406 polymorphism. Overall, a significant correlation was observed between the rs28362491 polymorphism and a decreased risk of HNCs (OR=0.76,95%CI=0.60‐0.97for DD vs. II;OR=0.80,95%CI=0.68‐0.95for DD vs. DI+II). In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). In addition, no statistical correlation was found between the polymorphism of rs2233406 and HNCs.Conclusion. rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. Additionally, our results showed that no association was discovered between rs2233406 polymorphism and HNCs.

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Association between CYP1A1 Ile462Val (m2, A2455G, rs1048943) polymorphism and head and neck cancer susceptibility: A meta-analysis, meta-regression, and trial sequential analysis

Gene Reports ◽

10.1016/j.genrep.2021.101380 ◽

2021 ◽

Vol 25 ◽

pp. 101380

Author(s):

Mazaher Ramezani ◽

Masoud Sadeghi ◽

Elisa Zavattaro ◽

Hamid Reza Mozaffari

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Sequential Analysis ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Trial Sequential Analysis ◽

Meta Regression

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Vitamin D in Head and Neck Cancer: a Systematic Review

Current Oncology Reports ◽

10.1007/s11912-020-00996-7 ◽

2020 ◽

Vol 23 (1) ◽

Author(s):

Antti Mäkitie ◽

Iida Tuokkola ◽

Göran Laurell ◽

Outi Mäkitie ◽

Kerry Olsen ◽

...

Keyword(s):

Vitamin D ◽

Head And Neck Cancer ◽

Head And Neck ◽

Vitamin D Deficiency ◽

Neck Cancer ◽

Cancer Diagnosis ◽

Case Control ◽

Healthy Population ◽

Inverse Association ◽

Case Control Studies

Abstract Purpose of review Observational studies have shown that serum 25-OH vitamin D [25(OH)D] is inversely associated with overall cancer risk in many malignancies. We performed a systematic literature review to determine whether vitamin D deficiency is related to head and neck cancer (HNC) etiology and outcome. Recent findings The search yielded five prospective studies reporting 25(OH)D levels prior to cancer diagnosis and their effect on the risk of HNC. Eight studies were cross-sectional or case-control studies, in which 25(OH)D levels were only measured after cancer diagnosis. Two studies found an inverse association between 25(OH)D level and HNC risk, while two other prospective cohort studies demonstrated no connection between 25(OH)D and HNC risk. Several studies reported cancer patients to have significantly lower 25(OH)D levels than controls. Associations between 25(OH)D and prognosis and mortality were variable. Summary The link between vitamin D and HNC has so far only been investigated in a few observational, prospective, and case-control studies. Vitamin D deficiency may be more common in HNC patients than in the healthy population. There is no evidence for a causal relationship. Further studies are needed to evaluate whether low 25(OH)D concentrations play a role in the development or outcome of HNCs.

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