scholarly journals Correlation Between Expression of Cell Adhesion Molecules CD44v6 and E-cadherin and Lymphatic Metastasis in Non-small Cell Lung Cancer

2014 ◽  
Vol 15 (5) ◽  
pp. 2221-2224 ◽  
Author(s):  
Chong-Yu Su ◽  
Yun-Song Li ◽  
Yi Han ◽  
Shi-Jie Zhou ◽  
Zhi-Dong Liu
Keyword(s):  
Lung Cancer ◽  
Cell Adhesion ◽  
Small Cell Lung Cancer ◽  
Adhesion Molecules ◽  
Cell Lung Cancer ◽  
Lymphatic Metastasis ◽  
Cell Adhesion Molecules ◽  
Small Cell ◽  
Small Cell Lung ◽  
E Cadherin

scholarly journals Cetuximab Attenuates Metastasis and u-PAR Expression in Non–Small Cell Lung Cancer: u-PAR and E-Cadherin are Novel Biomarkers of Cetuximab Sensitivity

2009 ◽  
Vol 69 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Dessislava A. Nikolova ◽  
Irfan A. Asangani ◽  
Laura D. Nelson ◽  
Dennis P.M. Hughes ◽  
Doris R. Siwak ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Novel Biomarkers ◽  
E Cadherin

scholarly journals Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus

2007 ◽  
Vol 60 (6) ◽  
pp. 608-614 ◽  
Author(s):  
M C Boelens ◽  
A van den Berg ◽  
I Vogelzang ◽  
J Wesseling ◽  
D S Postma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Differential Expression ◽  
Adhesion Molecules ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Successful treatment of pulmonary lymphangitic carcinomatosis by anlotinib in 14 Chinese patients with advanced non-small cell lung cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e21064-e21064
Author(s):  
Shencun Fang ◽  
Wanwan Cheng ◽  
Yingming Zhang ◽  
Haitao Zhang ◽  
Si Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Lymphatic Metastasis ◽  
Small Cell ◽  
Smoking History ◽  
Wild Type ◽  
Small Cell Lung ◽  
The Impact ◽  
Lymphangitic Carcinomatosis

e21064 Background: Pulmonary lymphangitic carcinomatosis (PLC) occurs in 6%-8% of intrathoracic metastases among malignant tumor. The median survival was only 2.0 months from time of pulmonary symptoms to death in cases during 2000-2018, which is a poor prognosis. Effective interventions were needed besides standard chemotherapy and symptomatic support. Anlotinib showed a critical effect on lymphangiogenesis, and lymphatic metastasis in mouse models of lung adenocarcinoma, it might be a therapeutic option for tumor lymphatic metastasis. In this study, we retrospectively analyzed the efficacy and safety of anlotinib for PLC in patients with Non-small Cell Lung Cancer (NSCLC). Methods: We retrospectively investigated NSCLC patients with PLC at our hospital between May 2018 and November 2020, who received anlotinib monotherapy or combined therapy for PLC. Data were analyzed for progression-free survival (PFS), overall survival (OS), objective response rate(ORR), disease control rate(DCR) and adverse events (AE). The impact of clinical and genomic factors on PFS and OS were also assessed. Results: A total of 14 patients were enrolled with a median age of 64 years. 10(71.4%) were male, 4(28.6%) has smoking history, 10(71.4%) of patients had a performance status of 2-3. 9, 3, 2 patients had TP53 mutation, EGFR mutation, ALK fusion respectively. 9(64.3%) patients received anlotinib monotherapy. Of 14 patients, 8 achieved partial response (PR), 5 presented stable disease (SD), 1 had progressed disease. The ORR and DCR were 57.1% and 92.9% respectively. The median PFS was 3.1 months (95% CI: 2.0-4.2), the median OS for 1, 2, ≥3 line were 13 months, 7.2 months, 5.2 months, respectively. Median PFS and OS (≥3 line) were significantly longer for patients with TP53-mutant tumors compared with those with TP53–wild-type tumors (median PFS: 7 vs. 1.1 months, median OS (≥3 line): 6.8 vs. 1.9 months). No difference of PFS and OS (≥3 line) was found between EGFR or ALK alteration and the corresponding wild type patients. The most frequently reported AEs were high blood pressure (11, 78.6%), hand foot syndrome (6, 42.9%), diarrhea (5, 35.7%), fatigue (4, 28.6%), hoarseness (3, 21.4%), proteinuria (2, 14.3%) and stomatitis (2, 14.3%). Conclusions: Anlotinib presented favorable efficacy in patients with pulmonary lymphangitic carcinomatosis and conferred considerable survival benefit compared with previous studies, especially in patients harboring TP53 mutations. The AEs were manageable. These indicated that anlotinib can be a promising therapeutic treatment of PLC. More clinical data is needed to validate this finding.

scholarly journals Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer

2013 ◽  
Vol 30 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
ARUM KIM ◽  
EUN YOUNG KIM ◽  
EUN NA CHO ◽  
HYUNG JUNG KIM ◽  
SE KYU KIM ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Adherens Junction ◽  
Small Cell ◽  
Small Cell Lung ◽  
Snail Family ◽  
E Cadherin

scholarly journals E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

Oncogene ◽  
2010 ◽  
Vol 29 (19) ◽  
pp. 2760-2771 ◽  
Author(s):  
L Asnaghi ◽  
W C Vass ◽  
R Quadri ◽  
P M Day ◽  
X Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Rho Gtpases ◽  
Small Cell ◽  
Small Cell Lung ◽  
Neoplastic Growth ◽  
E Cadherin

scholarly journals Alex3 suppresses non–small cell lung cancer invasion via AKT/Slug/E-cadherin pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (7) ◽  
pp. 101042831770144 ◽  
Author(s):  
Jiang Du ◽  
Xiupeng Zhang ◽  
Haijing Zhou ◽  
Yuan Miao ◽  
Yong Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Invasion ◽  
Small Cell ◽  
Small Cell Lung ◽  
E Cadherin

Analysis of factors influencing skip lymphatic metastasis in pN2 non-small cell lung cancer

2012 ◽  
Vol 24 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Gui-Long Li ◽  
Yong Zhu ◽  
Wei Zheng ◽  
Chao-Hui Guo ◽  
Chun Chen
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Lymphatic Metastasis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Factors Influencing
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