Helicobacter cinaedi–Associated Bacteremia and Cellulitis in Immunocompromised Patients

Tuberculous prostatitis is an uncommon form of tuberculosis infection. It is commonly seen in immunocompromised patients and in those of middle or advanced age. The diagnosis is often not straight forward due to the nature of its presentation. We report a case of tuberculous prostatitis in a young, healthy and immunocompetent patient, who initially presented with respiratory features, followed by episodes of seizures and testicular swelling. He was finally diagnosed with tuberculous prostatitis after prostatic biopsy. This case illustrates that in a high TB prevalence environment, when symptoms warrant, there should be a high clinical suspicion coupled with a thorough approach in order to arrive at a correct diagnosis of TB prostatitis.

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Detection of Cryptosporidium spp., Cyclospora spp. and Cystoisospora spp. cysts in faecal samples of immunocompromised patients using real-time PCR

10.26226/morressier.56d5ba2fd462b80296c9536c ◽

2016 ◽

Author(s):

Varol Tunali

Keyword(s):

Real Time ◽

Real Time Pcr ◽

Immunocompromised Patients ◽

Cryptosporidium Spp ◽

Faecal Samples

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Faculty Opinions recommendation of Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.719010846.793531894 ◽

2017 ◽

Author(s):

Alexandre Alanio

Keyword(s):

Pneumocystis Pneumonia ◽

Immunocompromised Patients

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Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas

Medicinal Chemistry ◽

10.2174/1573406416666191226142744 ◽

2020 ◽

Vol 16 (5) ◽

pp. 677-688 ◽

Cited By ~ 2

Author(s):

Sandra Piras ◽

Paola Corona ◽

Roberta Ibba ◽

Federico Riu ◽

Gabriele Murineddu ◽

...

Keyword(s):

Chronic Disease ◽

Antiviral Activity ◽

Wide Spectrum ◽

Immunocompromised Patients ◽

Human Pathogen ◽

Alkyl Aryl ◽

Dna Viruses ◽

Coxsackievirus B ◽

Selective Activity

Background: Coxsackievirus infections are associated with cases of aseptic meningitis, encephalitis, myocarditis, and some chronic disease. Methods: A series of benzo[d][1,2,3]triazol-1(2)-yl derivatives (here named benzotriazol-1(2)-yl) (4a-i, 5a-h, 6a-e, g, i, j and 7a-f, h-j) were designed, synthesized and in vitro evaluated for cytotoxicity and antiviral activity against two important human enteroviruses (HEVs) members of the Picornaviridae family [Coxsackievirus B 5 (CVB-5) and Poliovirus 1 (Sb-1)]. Results: Compounds 4c (CC50 >100 μM; EC50 = 9 μM), 5g (CC50 >100 μM; EC50 = 8 μM), and 6a (CC50 >100 μM; EC50 = 10 μM) were found active against CVB-5. With the aim of evaluating the selectivity of action of this class of compounds, a wide spectrum of RNA (positive- and negativesense), double-stranded (dsRNA) or DNA viruses were also assayed. For none of them, significant antiviral activity was determined. Conclusion: These results point towards a selective activity against CVB-5, an important human pathogen that causes both acute and chronic diseases in infants, young children, and immunocompromised patients.

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Community acquired pneumonia-current scenario among immunocompromised patients in a tertiary care hospital

International Journal of Bioassays ◽

10.21746/ijbio.2016.01.004 ◽

2016 ◽

Vol 5 (01) ◽

pp. 4715

Author(s):

A. V. Sowmya* ◽

G. Jayalakshmi ◽

David Agatha

Keyword(s):

Diabetes Mellitus ◽

Antimicrobial Therapy ◽

Tertiary Care ◽

Community Acquired Pneumonia ◽

Polymicrobial Infection ◽

Resistance Pattern ◽

Care Hospital ◽

Immunocompromised Patients ◽

Drug Resistant ◽

Etiologic Agents

Pneumonia is a common illness accounting for majority of hospitalizations worldwide with significant mortality and morbidity. Antimicrobial therapy, being the main stay of treatment, the choices of antibiotics depends on the nature of the etiologic agents and the host factors. The current study was aimed to identify the bacterial & fungal etiologic agents of Community Acquired Pneumonia (CAP) in Immunocompromised (IC) patients, with their antimicrobial resistant pattern and to analyze the associated immunocompromised states. Various respiratory samples from study group of 75 immunocompromised patients with features of pneumonia were collected, processed and the isolates were identified with their antimicrobial susceptibility& resistance pattern according to CLSI guidelines. The results were analyzed statistically. Diabetes mellitus is the most common immunocompromised state (48%) associated with CAP. Monomicrobial and polymicrobial infection rates were 80.36% and 19.64% respectively. Gram negative pathogens and fungal pathogens were identified in 60% and 25.37% of culture positive cases respectively. Diabetes mellitus is commonly found in association with polymicrobial infection (19.44%) and fungal infection (16.66%). Drug resistant strains comprise about 75% of MRSA strains, 72.72 % of ESBL producers and 3.44% of Amp C producers. As the number of elderly people with associated IC state is on rise, with change in the pattern of microbial etiologic agents causing CAP, a prior knowledge of the host and microbial factors will help in formulating empirical antimicrobial therapy and proper treatment thereby curbing the spread of infections by drug resistant pathogens and the associated morbidity and mortality.

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