scholarly journals Cutaneous Mucormycosis Arising in the Skin Folds of Immunocompromised Patients: A Case-Series

2021 ◽  
Author(s):  
Renajd Rrapi ◽  
Sidharth Chand ◽  
Rebecca Gaffney ◽  
Jennifer A. Lo ◽  
Jeffrey S. Smith ◽  
...  
2020 ◽  
Vol 2 (1) ◽  
pp. 69-74
Author(s):  
Marium Jamaluddin Ahmad ◽  
Tengku Ain Kamalden ◽  
Nurliza Khaliddin ◽  
Tajunisah Iqbal

Cytomegalovirus (CMV) retinitis is an opportunistic infection affecting immunocompromised patients. This case series describes 2 patients aged 19 and 10 years who were undergoing cancer treatment and were referred for complaints of worsening blurred vision. The retinal findings in the first patient showed multiple yellowishsubretinal areas with haemorrhages, while in the second patient there was presence of frosted branch angiitis. Confirmation of diagnosis was done using PCR of vitreous samples and blood CMV levels. Both tested negative for HIV. Both received intravitreal and systemic ganciclovir. It is important for ophthalmologists to consider CMVretinitis in all patients with any form of immunosuppression.


2021 ◽  
Vol 8 (4) ◽  
pp. 591
Author(s):  
Sneha Biradar ◽  
Balakrishna Teli

Cryptococcosis is an important opportunistic fungal infection and also cause of death due to central nervous system disease among patients with human immunodeficiency virus worldwide. Most of the cases occur in immunocompromised patients like HIV infected people, people with organ transplants and on immunosuppressants. Nowdays there is increase in cases of cryptoccal meningitis among diabetic patients. Current case series includes cryptococcal meningitis among diabetic patients after ruling out of other immunocompromised states. 


2019 ◽  
Vol 181 (2) ◽  
pp. 373-374
Author(s):  
S. McKenzie ◽  
P. Zang ◽  
P. Blackcloud ◽  
B. Cohen ◽  
A. Truong ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Praveen Gundelly ◽  
Yasuhiro Suzuki ◽  
Julie A. Ribes ◽  
Alice Thornton

Rhodococcus equiis an unusual zoonotic pathogen that can cause life-threatening diseases in susceptible hosts. Twelve patients withR. equiinfection in Kentucky were compared to 137 cases reported in the literature. Although lungs were the primary sites of infection in immunocompromised patients, extrapulmonary involvement only was more common in immunocompetent patients (P<0.0001). Mortality inR. equi-infected HIV patients was lower in the HAART era (8%) than in pre-HAART era (56%) (P<0.0001), suggesting that HAART improves prognosis in these patients. Most (85–100%) of clinical isolates were susceptible to vancomycin, clarithromycin, rifampin, aminoglycosides, ciprofloxacin, and imipenem. Interestingly, there was a marked difference in susceptibility of the isolates to cotrimoxazole between Europe (35/76) and the US (15/15) (P<0.0001). Empiric treatment ofR. equiinfection should include a combination of two antibiotics, preferably selected from vancomycin, imipenem, clarithromycin/azithromycin, ciprofloxacin, rifampin, or cotrimoxazole. Local antibiograms should be checked prior to using cotrimoxazole due to developing resistance.


2006 ◽  
Vol 193 (6) ◽  
pp. 760-764 ◽  
Author(s):  
Michael G. Ison ◽  
Larisa V. Gubareva ◽  
Robert L. Atmar ◽  
John Treanor ◽  
Frederick G. Hayden

2014 ◽  
Vol 52 (8) ◽  
pp. 819-825 ◽  
Author(s):  
Paul R. Ingram ◽  
Arul E. Suthananthan ◽  
Ruben Rajan ◽  
Todd M. Pryce ◽  
Kishore Sieunarine ◽  
...  

2021 ◽  
pp. 420-423
Author(s):  
Anita Anita ◽  
Shailesh Kumar ◽  
Namrata Kumari ◽  
Kamlesh Rajpal ◽  
Santosh Kumar ◽  
...  

Mucormycosis is an angioinvasive infection caused by fungi Mucorales which mainly occurs in immunocompromised patients. Aspergillosis is also an opportunistic fungal infection caused by Aspergillus species. Coinfection with mucormycosis and aspergillosis is very rare and very few cases were published in the literature till now. There is an increase in the incidence of mucormycosis infection in post-COVID-19 patients. Here, we are going to report a case series of three cases of combined infection of mucormycosis with Aspergillus. All three patients were treated with extensive surgical debridement and intravenous liposomal amphotericin B. Even after aggressive treatment, the mortality rate is high in these types of patients.


2019 ◽  
Vol 5 (1) ◽  
pp. 25 ◽  
Author(s):  
Pauline Devauchelle ◽  
Mathieu Jeanne ◽  
Emilie Fréalle

Patients with extensive burns are an important group at risk for cutaneous mucormycosis. This study aimed to perform a systematic review of all reported mucormycosis cases in burn patients from 1990 onward. A Medline search yielded identification of 7 case series, 3 outbreaks, and 25 individual cases reports. The prevalence reached 0.04%–0.6%. The median age was 42–48 in the case series and outbreaks, except for the studies from military centers (23.5–32.5) and in individual reports (29.5). The median total body surface area reached 42.5%–65%. Various skin lesions were described, none being pathognomonic: the diagnosis was mainly reached because of extensive necrotic lesions sometimes associated with sepsis. Most patients were treated with systemic amphotericin B or liposomal amphotericin B, and all underwent debridement and/or amputation. Mortality reached 33%–100% in the case series, 29%–62% during outbreaks, and 40% in individual cases. Most patients were diagnosed using histopathology and/or culture. Mucorales qPCR showed detection of circulating DNA 2–24 days before the standard diagnosis. Species included the main clinically relevant mucorales (i.e., Mucor, Rhizopus, Absidia/Lichtheimia, Rhizomucor) but also more uncommon mucorales such as Saksenaea or Apophysomyces. Contact with soil was reported in most individual cases. Bandages were identified as the source of contamination in two nosocomial outbreaks.


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