scholarly journals Ankle Proprioception in Patients with Type 2 Diabetes Mellitus

2021 ◽  
Vol 111 (4) ◽  
Author(s):  
Ozkan Maras ◽  
Deniz Dulgeroglu ◽  
Aytul Cakci
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Educational Level ◽  
Disease Duration ◽  
Position Sense ◽  
Joint Position Sense ◽  
Joint Position ◽  
Foot Complications ◽  
Ankle Proprioception

Background Ankle position sense may be reduced before the appearance of the clinical manifestation of diabetic peripheral neuropathy. This is known to impair gait and cause falls and foot ulcers. Early detection of impaired ankle proprioception is important because it allows physicians to prescribe an exercise program to patients to prevent foot complications. Methods Forty-six patients diagnosed as having type 2 diabetes mellitus and 22 control patients were included in the study. Presence of neuropathy was assessed using the Michigan Neuropathy Screening Instrument (MNSI). Level of foot care awareness was determined using the Nottingham Assessment of Functional Footcare (NAFF). Joint position sense was measured using a dynamometer. Results Mean absolute angular error (MAAE) values were significantly higher in the neuropathy group compared with the control group (P < .05). Right plantarflexion MAAE values were significantly lower in the group without neuropathy compared with the group with neuropathy (P < .05). No correlation was found between MAAE values (indicating joint position sense) and age, educational level, disease duration, glycemic control, NAFF score, and MNSI history and examination scores in the groups with and without neuropathy (P > .05). Educational level and disease duration were found to be correlated with NAFF scores. Conclusions Increased MNSI history scores and increased deficits in ankle proprioception demonstrate that diabetic foot complications associated with reduced joint position sense may be seen at an increased rate in symptomatic patients.

Effect of Type 2 Diabetes Mellitus and diabetic medication on Pulmonary Function

2021 ◽  
Vol 17 ◽  
Author(s):  
Alaa M. Hammad ◽  
Waleed Qirim ◽  
Ameen Alassi ◽  
Dana Hyassat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Pulmonary Function ◽  
Disease Duration ◽  
Linear Regression Analysis ◽  
Forced Expiratory Volume ◽  
Control Group

Background: Type 2 diabetes mellitus (T2DM) is a chronic condition with an impairing effect on multiple organs. Numerous respiratory disorders have been observed in patients with T2DM. However, T2DM e ect on pulmonary function is ff inconclusive. Aims: In this study, we investigated the effect of T2DM on respiratory function and the correlation of glycemic control, diabetes duration and insulin intake. Methods: 1500 patients were recruited for this study, 560 having T2DM for at least a year were included in the final data, in addition to 540 healthy volunteers. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% (FEF 25-75%), as well as FEV1/FVC ratio values were measured. Results: A two-sample t-test showed that z-scores produced by Al-Qerem et al.’s equations for FEV1, FVC, and FEF 25-75% were significantly lower for the T2DM group than the control group (p < 0.01). FEV1/FVC ratio in T2DM group were significantly higher (p < 0.01). Multiple linear regression analysis found that glycemic control represented by HbA1c as well as disease duration were negatively associated with pulmonary function (p < 0.01). However, insulin intake was found to have no significant correlation with the pulmonary function. Conclusion: T2DM was linked to reduced pulmonary function and was consistent with a restrictive ventilation pattern. HbA1c as well as disease duration were independent risk factors for reduced pulmonary function.

scholarly journals Educational level as a cause of type 2 diabetes mellitus: Caution from triangulation of observational and genetic evidence

2021 ◽  
Author(s):  
Nat Na-Ek ◽  
Juthamanee Srithong ◽  
Authakorn Aonkhum ◽  
Suthida Boonsom ◽  
Pimphen Charoen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Educational Level ◽  
Genetic Evidence

scholarly journals Polymorphism in the HaeIII single nucleotide polymorphism of the SLC2A1 gene and cardiovascular disease in the early type 2 diabetes mellitus

2021 ◽  
Vol 18 (5) ◽  
pp. 147916412110412
Author(s):  
Dong-Hwa Lee ◽  
Gun Woo Won ◽  
Yong Hee Lee ◽  
Jong Sung Shin ◽  
Eu Jeong Ku ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Disease Duration ◽  
University Hospital ◽  
Korean Patients ◽  
Short Disease Duration ◽  
Slc2a1 Gene

Introduction: SLC2A1 polymorphism may play a role in the smooth muscle cell proliferation and extracellular matrix synthesis in vessels. However, the role of SLC2A1 polymorphism on diabetic cardiovascular disease (CVD) have not yet been identified. In this study, we aimed to investigate the association between SLC2A1 HaeIII polymorphism and CVD in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration. Methods: A total of 846 patients with T2DM who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of SLC2A1 gene was determined by real time polymerase chain reaction method. Genotyping results were presented GG, AG, or AA. Subgroup analysis was performed according to duration of T2DM (⩽10, 11–20, >20 years). Results: The AA genotype was significantly associated with higher prevalence of CVD in patients with DM duration less than 10 years (26.3% vs 9.2%, p = 0.014). There was no significant association between SLC2A1 HaeIII polymorphism and other diabetic complications including, retinopathy, nephropathy, neuropathy, cerebrovascular disease, and peripheral artery disease. Conclusions: The SLC2A1 HaeIII polymorphism was associated with CVD in Korean patients with T2DM with short disease duration.

scholarly journals The Association Between Gender and Complications of Type 2 Diabetes Mellitus Among Patients in Almarj City-Libya

2020 ◽  
Vol 35 (2) ◽  
pp. 130-138
Author(s):  
Fatma KH. Ali Ehmaida ◽  
Sokaina Saad Hemdan ◽  
Asmaa M. Aljebaly
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Respiratory Dysfunction ◽  
Type 2 Diabetic Mellitus ◽  
Foot Complications ◽  
Life Threatening ◽  
And Gender ◽  
The Relationship

This study was carried out to provide new data on patients with type 2 diabetes mellitus and any suggestions for the prevention of what is a life-threatening disorder. Four hundred and seventy-three type 2 diabetic mellitus patients from Almarj general hospital were used: (222) females and (251) males for the period from October -2017 to April – 2018.The study focused on the relationship between genders and complications of diabetes mellitus. The study showed no significant differences (P > 0.05) between hypertension, heart disease, respiratory dysfunction, nephropathy, urinary tract infection, anemia, hypothyroidism, diabetic ketoacidosis, gastric infection, and gender. On the other hand, a significant (P ≤ 0.05) relationship was found between hepatopathy and foot complications and gender. Findings showed that males with the risk of the dangers of type 2 diabetes mellitus complications were more than females in Almarj city.  

scholarly journals Hypovitaminosis D in Patients with Type 2 Diabetes Mellitus: A Relation to Disease Control and Complications

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Hala Ahmadieh ◽  
Sami T. Azar ◽  
Najla Lakkis ◽  
Asma Arabi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Diabetic Neuropathy ◽  
Disease Duration ◽  
Independent Predictor ◽  
Microvascular Complications

Aims. This study aims at assessing the relationship between 25 (OH) vitamin D (25-OHD) levels and microvascular complications in patients with type 2 diabetes mellitus (DM2). Methods. 136 patients (59 ± 11 years) with DM2 (disease duration 8.6 ± 7 years) participated in this cross-sectional study. Anthropometric data, HbA1c, 25-OHD levels, serum creatinine, and urine microalbumin/creatinine ratio were collected. Dilated retinal exam was performed, and diabetic neuropathy was assessed using the United Kingdom Screening Score. Results. Serum 25-OHD correlated negatively with HbA1c (r=-0.20,  P=0.049). Mean 25-OHD levels were lower in subjects with diabetic retinopathy compared to those without retinopathy (12.3 ± 5.5 versus 21.8 ± 13.7, P<0.001) and lower in subjects with diabetic neuropathy compared to those without neuropathy (16.4 ± 10.4 versus 23.5 ± 14.5, P=0.004). After adjustment for BMI, diabetes duration, and smoking, 25-OHD was an independent predictor of HbA1c (β  −0.14; P=0.03). After adjustment for HbA1c, age, smoking, BMI and disease duration, 25-OHD were independent predictors for diabetic retinopathy: OR 2.8 [95% CI 2.1–8.0] and neuropathy: OR 4.5 [95% CI 1.6–12] for vitamin D < 20 versus vitamin D ≥ 20 ng/mL. Conclusion. Low serum 25-OHD level was an independent predictor of HbA1c, diabetic neuropathy, and diabetic retinopathy in patients with DM2.

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