Local antibiotic treatment of soft tissue and bone infections of the foot

1990 ◽  
Vol 80 (7) ◽  
pp. 345-353 ◽  
Author(s):  
DE Stabile ◽  
AM Jacobs
Keyword(s):  
Soft Tissue ◽  
Bone Cement ◽  
Success Rate ◽  
Polymethyl Methacrylate ◽  
Antibiotic Treatment ◽  
Soft Tissue Infection ◽  
Definitive Diagnosis ◽  
Histologic Examination ◽  
Bone Infections ◽  
Local Antibiotic

Twenty-seven pedal soft tissue and bone infections in 26 patients were treated with surgical necrectomy of infected tissues and implantation of antibiotic-loaded polymethyl methacrylate bone cement beads on chains. The definitive diagnosis of the infected tissues was obtained by culture and histologic examination in all of the cases. A wide variety of foot infections was successfully treated in this manner. The success rate without recurrence of osteomyelitis or soft tissue infection was 95% in this study at an average of 16 months after surgery.

scholarly journals Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection

2017 ◽  
Vol 49 (4) ◽  
pp. 301 ◽  
Author(s):  
Yee Gyung Kwak ◽  
Seong-Ho Choi ◽  
Tark Kim ◽  
Seong Yeon Park ◽  
Soo-Hong Seo ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Treatment ◽  
Soft Tissue Infection ◽  
Clinical Guidelines ◽  
Tissue Infection

Efficacy of Nano-Encapsulated Daptomycin in an Experimental Methicillin-Resistant Staphylococcus aureus (MRSA) Bone and Joint Infection Model

2021 ◽  
Author(s):  
Cedric Jacqueline ◽  
Jocelyne Caillon ◽  
Olivier Meyer ◽  
Eric Dailly ◽  
Carl Simonsson ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Treatment ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Systemic Treatment ◽  
Joint Infection ◽  
Local Administration ◽  
Infection Model ◽  
Systemic Antibiotic ◽  
Bone Infections ◽  
Local Antibiotic

S. aureus bone infections remain a therapeutic challenge, leading to long and expensive hospitalizations. Systemic antibiotic treatments are inconsistently effective due to insufficient penetration into the infectious site. In an osteomyelitis model, the single local administration of nanoparticle-encapsulated daptomycin allows sterilization of the infectious sites after 4 and 14 days of treatment, while daily systemic treatment of daptomycin for 4 days was not effective. These results demonstrate the great interest of this local antibiotic treatment.

Development and application of antibiotic-loaded bone cement beads

1990 ◽  
Vol 80 (7) ◽  
pp. 354-359 ◽  
Author(s):  
DE Stabile ◽  
AM Jacobs
Keyword(s):  
Soft Tissue ◽  
Antibiotic Therapy ◽  
Bone Cement ◽  
Clinical Judgment ◽  
Soft Tissue Infections ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Local Antibiotic ◽  
Vascular Status ◽  
Causes Of Failure

The authors presented an overview of the development of antibiotic-loaded bone cement beads and their indications for usage, method of application, advantages, disadvantages, and causes of failure. This method of treatment for bone and soft tissue infections of the foot is not a panacea and should be used only in selected cases. The vascular status and the physiologic ability of the patient to heal a peripheral wound or infection are the basis for the success of this method of therapy. European literature makes little mention of adjunctive systemic antibiotic therapy with local antibiotic-loaded bone cement bead use. It is the authors' opinion that clinical judgment should be used to determine the necessity for such therapy.

scholarly journals Validation of finger test for necrotising soft tissue infection

2020 ◽  
pp. 221049172096154
Author(s):  
Jimmy KY Lau ◽  
KB Kwok ◽  
YW Hung ◽  
CH Fan
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Predictive Value ◽  
Definitive Diagnosis ◽  
Tissue Infection ◽  
Clinical Judgement ◽  
Soft Tissue Infections ◽  
Pathological Findings ◽  
Surgical Exploration ◽  
Early Diagnostic

Background: Necrotising soft tissue infection (NSTI) is rare but fatal. Andreasen proposed finger test as an early diagnostic tool to differentiate NSTI from other soft tissue infections. We aim to evaluate the accuracy and reproducibility of the test for the diagnosis of NSTI. Methods: Patients who were admitted to our department from 2012 to 2016 with suspicion of NSTI and finger test done were retrospectively reviewed. Finger test was done and interpreted as described by Andreasen. Definitive diagnosis of NSTI was confirmed with surgical and pathological findings. Results: Among the 35 patients included in the study, NSTI was confirmed in 10 cases. Finger test had a sensitivity of 100%, a specificity of 80%, positive predictive value of 66.7%, negative predictive value of 100% and an overall accuracy of 85.7%. There was no difference in demographics or comorbidities between NSTI and non-NSTI groups. Surgeons involved had 76.7% agreement and moderate reproducibility (kappa = 0.48) on the diagnostic criteria of finger test. Conclusion: A negative finger test was reliable to exclude NSTI and a positive test suggested further surgical exploration. Yet, clinical judgement was still of paramount importance to treat NSTI promptly.

scholarly journals Spread of community-acquired meticillin-resistant Staphylococcusaureus skin and soft-tissue infection within a family: implications forantibiotic therapy and prevention

2010 ◽  
Vol 59 (4) ◽  
pp. 489-492 ◽  
Author(s):  
N. H. Amir ◽  
A. S. Rossney ◽  
J. Veale ◽  
M. O'Connor ◽  
F. Fitzpatrick ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Treatment ◽  
Soft Tissue Infection ◽  
Clinical Presentation ◽  
Tissue Infection ◽  
Recurrent Infections ◽  
Family Cluster ◽  
Empiric Antibiotic ◽  
Empiric Antibiotic Treatment

Outbreaks or clusters of community-acquired meticillin-resistant Staphylococcusaureus (CA-MRSA) within families have been reported. We describea family cluster of CA-MRSA skin and soft-tissue infection where CA-MRSA wassuspected because of recurrent infections which failed to respond to flucloxacillin.While the prevalence of CA-MRSA is low worldwide, CA-MRSA should be consideredin certain circumstances depending on clinical presentation and risk assessment.Surveillance cultures of family contacts of patients with MRSA should be consideredto help establish the prevalence of CA-MRSA and to inform the optimal choiceof empiric antibiotic treatment.

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