scholarly journals Context-dependent signaling of coincident auditory and visual events in primary visual cortex

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Thomas Deneux ◽  
Evan R Harrell ◽  
Alexandre Kempf ◽  
Sebastian Ceballo ◽  
Anton Filipchuk ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Auditory Cortex ◽  
Primary Visual Cortex ◽  
Cell Types ◽  
Dependent Manner ◽  
Visual Responses ◽  
Loud Sound ◽  
Visual Events ◽  
Dominant Feature ◽  
Context Dependent

Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.

scholarly journals Context-dependent signaling of coincident auditory and visual events in primary visual cortex

2018 ◽  
Author(s):  
Thomas Deneux ◽  
Alexandre Kempf ◽  
Brice Bathellier
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Calcium Imaging ◽  
Cell Types ◽  
Visual Responses ◽  
Sound Sources ◽  
Two Photon ◽  
Visual Events ◽  
Visual Inputs ◽  
Sensory Modalities

AbstractDetecting rapid coincident changes across sensory modalities is essential to recognize sudden threats and events. Using two-photon calcium imaging in identified cell types in awake mice, we show that auditory cortex (AC) neurons projecting to primary visual cortex (V1) preferentially encode the abrupt onsets of sounds. In V1, a sub-population of layer 1 interneurons gates this selective cross-modal information by a suppression specific to the absence of visual inputs. However, when large auditory onsets coincide with visual stimuli, visual responses are strongly boosted in V1. Thus, a dynamic asymmetric circuit across AC and V1 specifically identifies visual events starting simultaneously to sudden sounds, potentially catalyzing localization of new sound sources in the visual field.

scholarly journals Author response: Context-dependent signaling of coincident auditory and visual events in primary visual cortex

2019 ◽  
Author(s):  
Thomas Deneux ◽  
Evan R Harrell ◽  
Alexandre Kempf ◽  
Sebastian Ceballo ◽  
Anton Filipchuk ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Author Response ◽  
Visual Events ◽  
Context Dependent

scholarly journals Mechanisms of Direction Selectivity in Cat Primary Visual Cortex as Revealed by Visual Adaptation

2010 ◽  
Vol 104 (5) ◽  
pp. 2615-2623 ◽  
Author(s):  
Nicholas J. Priebe ◽  
Ilan Lampl ◽  
David Ferster
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Cortical Neurons ◽  
Visual Stimulation ◽  
Direction Selectivity ◽  
Dependent Manner ◽  
Visual Responses ◽  
Null Direction ◽  
Simple Cells ◽  
Complex Cells

In contrast to neurons of the lateral geniculate nucleus (LGN), neurons in the primary visual cortex (V1) are selective for the direction of visual motion. Cortical direction selectivity could emerge from the spatiotemporal configuration of inputs from thalamic cells, from intracortical inhibitory interactions, or from a combination of thalamic and intracortical interactions. To distinguish between these possibilities, we studied the effect of adaptation (prolonged visual stimulation) on the direction selectivity of intracellularly recorded cortical neurons. It is known that adaptation selectively reduces the responses of cortical neurons, while largely sparing the afferent LGN input. Adaptation can therefore be used as a tool to dissect the relative contribution of afferent and intracortical interactions to the generation of direction selectivity. In both simple and complex cells, adaptation caused a hyperpolarization of the resting membrane potential (−2.5 mV, simple cells, −0.95 mV complex cells). In simple cells, adaptation in either direction only slightly reduced the visually evoked depolarization; this reduction was similar for preferred and null directions. In complex cells, adaptation strongly reduced visual responses in a direction-dependent manner: the reduction was largest when the stimulus direction matched that of the adapting motion. As a result, adaptation caused changes in the direction selectivity of complex cells: direction selectivity was reduced after preferred direction adaptation and increased after null direction adaptation. Because adaptation in the null direction enhanced direction selectivity rather than reduced it, it seems unlikely that inhibition from the null direction is the primary mechanism for creating direction selectivity.

scholarly journals 3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex

2020 ◽  
Author(s):  
Yang-Sun Hwang ◽  
Catherine Maclachlan ◽  
Jérôme Blanc ◽  
Anaëlle Dubois ◽  
Carl C H Petersen ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Pyramidal Neuron ◽  
Cell Types ◽  
Gabaergic Neurons ◽  
Inhibitory Synapses ◽  
Synaptic Inputs ◽  
Neuronal Types ◽  
The Difference ◽  
Ultrastructure Of Synapses

Abstract Synapses are the fundamental elements of the brain’s complicated neural networks. Although the ultrastructure of synapses has been extensively studied, the difference in how synaptic inputs are organized onto distinct neuronal types is not yet fully understood. Here, we examined the cell-type-specific ultrastructure of proximal processes from the soma of parvalbumin-positive (PV+) and somatostatin-positive (SST+) GABAergic neurons in comparison with a pyramidal neuron in the mouse primary visual cortex (V1), using serial block-face scanning electron microscopy. Interestingly, each type of neuron organizes excitatory and inhibitory synapses in a unique way. First, we found that a subset of SST+ neurons are spiny, having spines on both soma and dendrites. Each of those spines has a highly complicated structure that has up to eight synaptic inputs. Next, the PV+ and SST+ neurons receive more robust excitatory inputs to their perisoma than does the pyramidal neuron. Notably, excitatory synapses on GABAergic neurons were often multiple-synapse boutons, making another synapse on distal dendrites. On the other hand, inhibitory synapses near the soma were often single-targeting multiple boutons. Collectively, our data demonstrate that synaptic inputs near the soma are differentially organized across cell types and form a network that balances inhibition and excitation in the V1.

scholarly journals Morphological and Physiological Characterization of Layer VI Corticofugal Neurons of Mouse Primary Visual Cortex

2003 ◽  
Vol 89 (5) ◽  
pp. 2854-2867 ◽  
Author(s):  
Joshua C. Brumberg ◽  
Farid Hamzei-Sichani ◽  
Rafael Yuste
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Action Potentials ◽  
Three Dimensional ◽  
Cell Types ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Morphological Properties ◽  
Feedback Connection ◽  
Physiological Characterization ◽  
Layer Vi

Layer VI is the origin of the massive feedback connection from the cortex to the thalamus, yet its complement of cell types and their connections is poorly understood. The physiological and morphological properties of corticofugal neurons of layer VI of mouse primary visual cortex were investigated in slices loaded with the Ca2+indicator fura-2AM. To identify corticofugal neurons, electrical stimulation of the white matter (WM) was done in conjunction with calcium imaging to detect neurons that responded with changes in intracellular Ca2+ concentrations in response to the stimulation. Subsequent whole cell recordings confirmed that they discharged antidromic action potentials after WM stimulation. Antidromically activated neurons were more excitable and had different spiking properties than neighboring nonantidromic neurons, although both groups had similar input resistances. Furthermore, antidromic neurons possessed narrower action potentials and smaller afterhyperpolarizations. Additionally, three-dimensional reconstructions indicated that antidromically activated neurons had a distinct morphology with longer apical dendrites and fewer nonprimary dendrites than nonantidromic cells. To identify the antidromic neurons, rhodamine microspheres were injected into the dorsal lateral geniculate nucleus of the thalamus and allowed to retrogradely transport back to the somata of the layer VI cortico-geniculate neurons. Physiological and anatomical analysis indicated that most antidromic neurons were likely to be cortico-geniculate neurons. Our results show that cortico-thalamic neurons represent a specific functional and morphological class of layer VI neurons.

Olfactory Bulb

2017 ◽  
pp. 309-322
Author(s):  
Gordon M. Shepherd ◽  
Michele Migliore ◽  
Francesco Cavarretta
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Visual Cortex ◽  
Olfactory Bulb ◽  
Primary Visual Cortex ◽  
Antennal Lobe ◽  
Cell Types ◽  
Synaptic Interactions ◽  
The Central Nervous System ◽  
Olfactory Input

The olfactory bulb is the site of the first synaptic processing of the olfactory input from the nose. It is present in all vertebrates (except cetaceans) and a the analogous antennal lobe in most invertebrates. With its sharply demarcated cell types and histological layers, and some well-studied synaptic interactions, it is one of the first and clearest examples of the microcircuit concept in the central nervous system. The olfactory bulb microcircuit receives the information in the sensory domain and transforms it into information in the neural domain. Traditionally, it has been considered analogous to the retina in processing its sensory input, but that has been replaced by the view that it is more similar to the thalamus or primary visual cortex in processing its multidimensional input. This chapter describes the main synaptic connections and functional operations and how they provide the output to the olfactory cortex

scholarly journals Pure tones modulate the representation of orientation and direction in the primary visual cortex

2019 ◽  
Vol 121 (6) ◽  
pp. 2202-2214 ◽  
Author(s):  
John P. McClure ◽  
Pierre-Olivier Polack
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Visual Stimulus ◽  
Visual Stimuli ◽  
Direction Selectivity ◽  
Multimodal Integration ◽  
Visual Responses ◽  
V1 Neurons ◽  
Pure Tones ◽  
The Impact

Multimodal sensory integration facilitates the generation of a unified and coherent perception of the environment. It is now well established that unimodal sensory perceptions, such as vision, are improved in multisensory contexts. Whereas multimodal integration is primarily performed by dedicated multisensory brain regions such as the association cortices or the superior colliculus, recent studies have shown that multisensory interactions also occur in primary sensory cortices. In particular, sounds were shown to modulate the responses of neurons located in layers 2/3 (L2/3) of the mouse primary visual cortex (V1). Yet, the net effect of sound modulation at the V1 population level remained unclear. In the present study, we performed two-photon calcium imaging in awake mice to compare the representation of the orientation and the direction of drifting gratings by V1 L2/3 neurons in unimodal (visual only) or multimodal (audiovisual) conditions. We found that sound modulation depended on the tuning properties (orientation and direction selectivity) and response amplitudes of V1 L2/3 neurons. Sounds potentiated the responses of neurons that were highly tuned to the cue’s orientation and direction but weakly active in the unimodal context, following the principle of inverse effectiveness of multimodal integration. Moreover, sound suppressed the responses of neurons untuned for the orientation and/or the direction of the visual cue. Altogether, sound modulation improved the representation of the orientation and direction of the visual stimulus in V1 L2/3. Namely, visual stimuli presented with auditory stimuli recruited a neuronal population better tuned to the visual stimulus orientation and direction than when presented alone. NEW & NOTEWORTHY The primary visual cortex (V1) receives direct inputs from the primary auditory cortex. Yet, the impact of sounds on visual processing in V1 remains controverted. We show that the modulation by pure tones of V1 visual responses depends on the orientation selectivity, direction selectivity, and response amplitudes of V1 neurons. Hence, audiovisual stimuli recruit a population of V1 neurons better tuned to the orientation and direction of the visual stimulus than unimodal visual stimuli.

A collicular visual cortex: Neocortical space for an ancient midbrain visual structure

Science ◽  
2019 ◽  
Vol 363 (6422) ◽  
pp. 64-69 ◽  
Author(s):  
Riccardo Beltramo ◽  
Massimo Scanziani
Keyword(s):  
Cerebral Cortex ◽  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Visual Information ◽  
Cortical Area ◽  
Moving Objects ◽  
Visual Responses ◽  
Visual Cortical Area ◽  
Postrhinal Cortex ◽  
Visual Cortical

Visual responses in the cerebral cortex are believed to rely on the geniculate input to the primary visual cortex (V1). Indeed, V1 lesions substantially reduce visual responses throughout the cortex. Visual information enters the cortex also through the superior colliculus (SC), but the function of this input on visual responses in the cortex is less clear. SC lesions affect cortical visual responses less than V1 lesions, and no visual cortical area appears to entirely rely on SC inputs. We show that visual responses in a mouse lateral visual cortical area called the postrhinal cortex are independent of V1 and are abolished upon silencing of the SC. This area outperforms V1 in discriminating moving objects. We thus identify a collicular primary visual cortex that is independent of the geniculo-cortical pathway and is capable of motion discrimination.

scholarly journals Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Janelle MP Pakan ◽  
Scott C Lowe ◽  
Evelyn Dylda ◽  
Sander W Keemink ◽  
Stephen P Currie ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Pyramidal Neurons ◽  
Visual Stimulation ◽  
Inhibitory Neurons ◽  
Behavioral State ◽  
Visual Responses ◽  
Cell Type ◽  
Sensory Stimuli ◽  
Context Dependent

Cortical responses to sensory stimuli are modulated by behavioral state. In the primary visual cortex (V1), visual responses of pyramidal neurons increase during locomotion. This response gain was suggested to be mediated through inhibitory neurons, resulting in the disinhibition of pyramidal neurons. Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive. Context-dependent locomotion responses were found in each cell type, with the highest proportion among SST neurons. These findings establish that modulation of neuronal activity by locomotion is context-dependent and contest the generality of a disinhibitory circuit for gain control of sensory responses by behavioral state.

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