scholarly journals Author response: Ribosome biogenesis restricts innate immune responses to virus infection and DNA

2019 ◽  
Author(s):  
Christopher Bianco ◽  
Ian Mohr
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Ribosome Biogenesis ◽  
Innate Immune ◽  
Author Response ◽  
Innate Immune Responses

scholarly journals Ribosome biogenesis restricts innate immune responses to virus infection and DNA

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Christopher Bianco ◽  
Ian Mohr
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Ribosome Biogenesis ◽  
Developmental Disorders ◽  
High Mobility ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Nucleolar Activity ◽  
Virus Reproduction ◽  
Nucleolar Stress

Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find that restricting ribosome biogenesis stimulated human cytomegalovirus (HCMV) replication without suppressing translation. Interfering with ribosomal RNA (rRNA) accumulation triggered nucleolar stress and repressed expression of 1392 genes, including High Mobility Group Box 2 (HMGB2), a chromatin-associated protein that facilitates cytoplasmic double-stranded (ds) DNA-sensing by cGAS. Furthermore, it reduced cytoplasmic HMGB2 abundance and impaired induction of interferon beta (IFNB1) mRNA, which encodes a critical anti-proliferative, proinflammatory cytokine, in response to HCMV or dsDNA in uninfected cells. This establishes that rRNA accumulation regulates innate immune responses to dsDNA by controlling HMGB2 abundance. Moreover, it reveals that rRNA accumulation and/or nucleolar activity unexpectedly regulate dsDNA-sensing to restrict virus reproduction and regulate inflammation. (145 words)

Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia

2019 ◽  
Vol 77 (8) ◽  
pp. 1607-1622 ◽  
Author(s):  
Aaron T. Irving ◽  
Pritisha Rozario ◽  
Pui-San Kong ◽  
Katarina Luko ◽  
Jeffrey J. Gorman ◽  
...  
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Dengue Virus ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Positive Serology ◽  
Dengue Virus Infection

scholarly journals Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection

2010 ◽  
Vol 30 (4) ◽  
pp. 263-272 ◽  
Author(s):  
Radiah A. Corn Minor ◽  
Gino V. Limmon ◽  
Laura Miller-DeGraff ◽  
Darlene Dixon ◽  
Danica M.K. Andrews ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Protein Kinase ◽  
Virus Infection ◽  
Immune Responses ◽  
Respiratory Syncytial Virus Infection ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Double Stranded Rna ◽  
Syncytial Virus

scholarly journals Aedes aegypti Saliva Enhances Dengue Virus Infection of Human Keratinocytes by Suppressing Innate Immune Responses

2012 ◽  
Vol 132 (8) ◽  
pp. 2103-2105 ◽  
Author(s):  
Pornapat Surasombatpattana ◽  
Sirilaksana Patramool ◽  
Natthanej Luplertlop ◽  
Hans Yssel ◽  
Dorothée Missé
Keyword(s):  
Virus Infection ◽  
Aedes Aegypti ◽  
Immune Responses ◽  
Dengue Virus ◽  
Human Keratinocytes ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Dengue Virus Infection
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